This meeting, organized jointly by the Biophysical Society (BPS), the Max Delbrück Center for Molecular Medicine Berlin, the German Center for Cardiovascular Diseases (DZHK), and the Berlin Institute of Health, was a great success. Over 120 participants from 15 countries with common interest in cardiology and biology attend the meeting to share their research. The focus on mathematical and biophysical models coupled with experiments set this meeting apart from cardiological and biological meetings. The meeting was highly interdisciplinary with contributions from medicine, biology, physics, bioengineering, and mathematics. Specifically, topics included subcellular structures, excitation-contraction coupling, metabolism, contraction, organ electrophysiology, heart mechanics, total heart function, disease modelling and therapy from combined modelling and experimental perspectives.