Subgroup Annual Meeting Symposia

The 12 Society subgroups will hold symposia on Saturday, February 2, 2013, in Philadelphia, Pennsylvania. For complete session information
for each subgroup visit

Bioenergetics Exocytosis & Endocytosis Molecular Biophysics
Biological Fluorescence Mechanobiology Motility
Biopolymers in vivo Membrane Biophysics Nanoscale Biophysics
Intrinsically Disordered Proteins Membrane Structure & Assembly Permeation & Transport



Jan Hoek, Thomas Jefferson University, and György Hajnóczky, Thomas Jefferson University, Subgroup Co-Chairs

Morning Symposium: Mitochondrial Calcium Signaling: New Insights after Molecular Identification of the Calcium Uniporter

Vasmi K Mootha, Harvard Medical School, The Mitochondrial Uniporter: From Molecular Identification to Physiology
Rosario Rizzuto, University of Padova, Italy, and György Hajnóczky, Thomas Jefferson University
Shey-Shing Sheu, Thomas Jefferson University, Multiple Mitochondrial Calcium Influx Mechanisms: Physiological and Pathological Implication
Brian O’Rourke, Johns Hopkins University, and W. Jonathan Lederer, University of Maryland

Afternoon Symposium: Mitophagy and Mitochondrial Dynamics

Heidi M. McBride, McGill University, Canada, Mitochondrial Dynamics and Quality Control
Hiromi Sesaki, Johns Hopkins University, Mitochondrial Dynamics in Neurodegeneration
John J. Lemasters, Medical University of South Carolina, Initiators of Type 1 and 2 Mitophagy
Richard J. Youle, National Institutes of Health, PINK1- and Parkin-mediated Mitophagy

Biological Fluorescence

Joachim Mueller, University of Minnesota, Subgroup Chair
Jonas Ries, ETH Zürich, Switzerland, Novel Labeling Schemes for Single-Molecule Localization Microscopy
David Piston, Vanderbilt University, Simultaneous Imaging of Vesicle Trafficking and Calcium-Mediated Exocytosis in Pancreatic Beta-Cells
Michael Levene, Yale University, Invasive Optics for Watching the Brain Work
David Millar, Scripps Research Institute, Assembly and Dynamics of Nucleic Acid – Protein Complexes at the Single-Molecule Level
Rong Li Stowers, Institute of Medical Research

Biopolymers in vivo

Pernilla Wittung-Stafshede, Umea University, Sweden, Subgroup Chair

10:00 am Subroup Business Meeting

Keynote Speaker: Jacqueline Barton, California Institute of Technology, DNA-mediated Signaling
Yousif Shamoo, Rice University, Small Changes in Enzyme Function can lead to Surprisingly Large in vivo Effects
Patricia Clark, Notre Dame University, New Directions for Vectorial Protein Folding

Postdoc Talks

Keynote Speaker: Stefan W. Hell, Max-Planck Insitute, Germany, Nanoscopy with Focused Light

Jie Xiao, Johns Hopkins University, Structures and Dynamics of the E. coli FTSZ-Ring and its Associated Proteins During Cell Division Revealed by Superresolution Imaging
John R. Briggs, European Molecular Biology Laboratory, Germany, Solving Structure in situ using Cryo- Electron Tomography and Correlative Methods
Gael McGill, Digizyme

7:00 pm Subgroup Dinner

Exocytosis & Endocytosis

Corey Smith, Case Western Reserve University, Subgroup Chair
Ege Kavalali, University of Texas, Southwestern Medical Center, Molecular Basis and Physiological Consequences of Synaptic Vesicle Pool Heterogeneity
Volker Haucke, University of Berlin, Germany, Molecular Mechanism of Synaptic Vesicle Exo-Endocytosis
José Lemos, University of Massachusetts Medical School, Role of Intracellular Calcium in Release from Nerve Terminals
Elise Stanley, University of Toronto, Canada
James Rothman, Yale University, Katz Award Lecture, Control of Membrane Fusion in Exocytosis

Intrinsically Disordered Proteins

Doug Barrick, Johns Hopkins University, Subgroup Chair

Functional Roles of Protein Disorder

Keynote Speaker: Lila Gierasch, University of Massachusetts, Amherst, Moving the Protein Folding Problem from the Test Tube to the Cell

Keynote Speaker: Peter Wright, Scripps Research Institute, IDP Research in 2013: what have we accomplished and where are we going?

James Bardwell, University of Michigan, Structural Studies on the Activation and Substrate Binding of a Conditionally Disordered Acid-Activated Chaperone
Ad Bax, National Institutes of Health, Alpha-Synuclein, An Intrinsically Unstructured Protein.How Interesting Can It Be?
Liesbeth Veenhoff, University of Groningen, The Netherlands, A Long Disordered Linker in Nuclear Transport of Membrane Proteins
Garagin Papoian, University of Maryland, Acetylations of Lysines of the H4 Histone Tail lead to Functionally Important Remodeling of its Energy Landscape
Jeffrey Hayes, University of Rochester, Linker Histone Structural Transitions upon Binding to DNA, Mononucleosomes, and Oligonucleosomal Arrays
Jörg Langowski, German Cancer Research Center, Germany, Dynamics of Nucleosome Tails Studied by All-Atom and Course-Grained MD Simulations
Elisar Barbar, Oregon State University, Intrinsic Protein Disorder in the Regulation of Large Molecular Machines
Jennifer Lee, National Institutes of Health, Membrane Curvature Generation by α-Synuclein
Ben Schuler, University of Zürich, Switzerland, Probing the Polymeric Properties of Unfolded and Disordered Proteins with Single-Molecule Spectroscopy


Linda Kenney, University of Illinois, Chicago, Organizer
Dennis Discher, University of Pennsylvania, From Matrix Elasticity to Nuclear Physics in Lineage Programs
GV Shivashankar, National University of Singapore, Singapore, Nuclear Mechanics and Genome Regulation
Mike Dustin, New York University, T-cell Receptor-Associated Actin Patches Generated by Wiskott-Aldrich Syndrome
Antoine Triller, Institute of Biology at Ecole Normale Superieure (IBENS), France, Synapse Stability and Plasticity: From Super-Resolution to Physical Chemistry of Molecular Interactions
Jennifer Zallen, Rockefeller University, Shaping the Embryo: Cellular Dynamics in Development
Rob Phillips, California Institute of Technology, Bacteria Are Stressed Out Too: The Physics of Mechanosensation

Membrane Biophysics

Diomedes Logothetis, Virginia Commonwealth University, Subgroup Chair, Regulation of K Channels by the G Protein Signaling System
Ming Zhou, Baylor College of Medicine, Structural Basis of Gating by RCK Domains
Eitan Reuveny, Weizmann Institute, Israel, Regulation of Store Operated Calcium Entry by SARAF
William A. Catterall, University of Washington, Calcium Channel Regulation in the Fight-or-Flight Response

3:05 pm Subgroup Business Meeting

Bonnie A. Wallace, University of London, United Kingdom, The Open Conformation of a Voltage-Gated Na Channel Reveals the Transmembrane Pathway and Gating Mechanism
Kevin J. Foskett, University of Pennsylvania, Regulatory Proteins of a Mitochondrial Calcium Uniporter
Peter H. Larsson, University of Miami, Regulation of Voltage Sensor Movement in KCNQ Channels by KCNE Beta Subunits

Membrane Structure & Assembly

Heiko Heerklotz, University of Toronto, Canada, Subgroup Chair
Ole Mouritsen, University of Southern Denmark, Denmark, Fatty Acids and Lysolipids Perturb Lipid Membranes: Implications for Drug Delivery
Sandro Keller, University of Kaiserslautern, Germany, Functional Reconstitution of Membrane Proteins by Isothermal Titration Calorimetry
Erwin London, Stony Brook University, Both Detergent Effects Upon Domain Size and Transmembrane Protein Length Effects Upon Domain
Binding Suggest that Hydrophobic Mismatch can Control the Properties of Ordered Membrane Domains (“Rafts”)

Bill Wimley, Tulane University, Thompson Award Winner, Discovering Highly Potent Pore-Forming Peptides Using Synthetic Molecular Evolution
Klaus Gawrisch, National Institutes of Health, Detergents for Extraction, Purification, and Reconstitution of G Protein-Coupled Membrane Receptors
Allan Grossfield, University of Rochester Medical Center, Exploring the Mechanisms of Antimicrobial Lipopeptides with Molecular Simulation

Molecular Biophysics

Jan Lipfert, Delft University of Technology, The Netherlands, Subgroup Chair, Probing the Response of Double-Stranded RNA to Force and Torque at the Single-Molecule Level
Craig Hetherington, University of California, Berkeley, DNA Rotation During Viral Packaging Reveals Motor Mechanisms and Genome Organization
Taekjip Ha, University of Illinois, Urbana-Champaign, Single Molecule Fluorescence-Force Analysis of DNA and Nucleosome
John Marko, Northwestern University, Torque and Dynamics of Linking Number Relaxation in Stretched Supercoiled DNA
Michelle Wang, Cornell University, Biomolecular Processes under Torque
Paul Lebel, Stanford University, Torque, Twist, and Extension of DNA at Millisecond Resolution using AU-RBT
Dominik Kauert, Dresden University of Technology, Germany, Single Molecule Mechanical Measurements Using 3D DNA-Origami Nanostructures


Mihaly Kovacs, Eotvos Lorand University, Hungary, and Christopher Yengo, Pennsylvania State University, Subgroup Co-Chairs
Ahmet Yildiz, University of California, Berkeley, The Mechanism of Cytoplasmic Dynein Motility
Zeynep Ökten, Ludwig Maximilians University, Germany, What Determines the Path of Kinesin Along the Microtubules?

Poster Highlights

Georgios Tsiavaliaris, Hannover Medical School, Germany, Mechansims of Mechanochemical Coupling in Low and High Duty Ratio Myosins
Andras Malnasi-Csizmadia, Eotvos Lorand University, Hungary, Communication Pathways between the Functional Regions in Myosin Motor Domain

2:45 pm Subgroup Business Meeting

Toshio Yanagida, Osaka University, Japan, From Single Molecule Fluctuation to Muscle Contraction: A Brownian Model of A.F. Huxley’s Hypothesis
Stephen Kowalczykowski, University of California, Davis, Watching Individual DNA Helicases and Motor Proteins Behaving and Misbehaving

Keynote Speaker: Susan Gilbert, Rensselaer Polytechnic Institute, Kinesin-14: A League of their Own

Nanoscale Biophysics

Joerg Bewersdorf, Yale University School of Medicine,and Victoria Birkedal, Aarhus University, Denmark, Subgroup Co-Chairs
Christian Eggeling, Max Planck Institute, Germany & Oxford University, United Kingdom, New Insight into Lipid-Protein Membrane Organization and Its Functionality with Super-Resolution STED Microscopy
Mark Ellisman, University of California, San Diego, Correlated Microscopies:Tools &Technologies for Multiscale-Multimodel Imaging and Information Integration
Helmut Grubmuller, Max Planck Institute, Germany, Dynamics of the Ribosomal Subunit Interface During tRNA Transolcation at Near-Atomic Resolution
Marija Drndic, University of Pennsylvania, Nanopore Graphene-based Electronic Devices
Julio Fernandez, Columbia University, Single Molecule Enzymology
Scott Blanchard, Cornell University, Allosteric Control of the Ribosome by Small-Molecule Antibiotics
Viola Vogel, ETH Zürich, Switzerland, Proteins as Mechano-Chemical Signalling Switches

Permeation & Transport

Dirk Gillespie, Rush University Medical Center, Subgroup Chair
Lambertus Van den Berg, University of Massachusetts Medical School, Understanding Outer Membrane Transport of Small Molecules by Pseudomonas aeruginosa
Gerhard Hummer, National Institutes of Health, Water Mediated Membrane Transport: From Channels to Proton Pumps
Edward Yu, Iowa State University, Structure and Mechanism of the Tripartite CusCBA Heavy-Metal Efflux Complex

November 2012 Table of Contents