Drug Discovery for Ion Channels XIV

Drug Discovery for Ion Channels XIV

Friday, February 14, 2014
Moscone Center, Room 130/131
8:00 AM: Registration Opens
8:30 AM: Program Begins
12:15 PM - 1:30 PM: Lunch (provided)
5:15 PM: Program Ends

Click here to register for the Satellite Meeting. 

Ion channels are an important class of therapeutic drug targets, and mutations in ion channel genes are found to be responsible for an increasing number of diseases.  While conventional electrophysiological techniques permit the most detailed and direct study of ion channel function, they are limited due to the manual nature of the method and their low throughput.  Because of this, ion channels remain an underrepresented target class for drug discovery. The advent of higher throughput automated electrophysiology systems has begun to change the face of ion channel drug discovery. This symposium will review the advances in automated electrophysiology and other emerging technologies and their impact on ion channel drug discovery today. This year’s meeting will highlight presentations from users of automated electrophysiology instrumentation as well as other speakers in the field of ion channel drug discovery.  


8:00 AM - 8:30 AMRegistration/Introduction
Session I, Chair: Niels Fertig 
8:30 AM - 9:15 AMKeynote Speaker: Bill Catterall, University of Washington, USA 
Structural Basis for Function of Voltage-Gated Sodium and Calcium Channels
9:15 AM - 9:45 AMJim Herrington, Bristol Meyers Squibb
Mechanistic Screening of LGIC PAMs by Manual and Automated Electrophysiology
9:45 AM - 10:15 AM Liudmila Polonchuk, F. Hoffmann-La Roche Ltd, Switzerland
Explore New Frontiers with Automated Electrophysiology! 
10:15 AM - 10:45 AM Break
Session II, Chair: Chris Mathes 
10:45 AM - 11:15 AM Pamela Tranter, Novartis Horsham, United Kingdom
Strategies for Screening TRPC and TRPM Channels
11:15 AM - 11:45 AMUlrich Ebbinghaus and Matthias Voemel, BayerCropScience, Germany
Automated Patch Clamp @ Bayer – from 1 to 768 Recording Channels
11:45 AM - 12:15 PM Benjamin Gaston, University Hospitals in Cleveland
Industry-academic Collaboration to Improve CFTR Corrector Activity
12:15 PM - 1:30 PM Break (lunch provided)
Session III, Chair: Morten Sunesen 
1:30 PM - 2:15 PM Keynote Speaker: Kevin Foskett, University of Pennsylvania, USA
Calcium Homeostasis Modulator (CALHM) Ion Channels: Structure, Functions and Physiological Roles
2:15 PM -  2:45 PM Bogdan Amuzescu, University of Bukarest, Romania
Diaryldiamidines Interaction with ASIC1a as a Basis for Novel Pharmacological Targets in Neuronal Ischemia 
2:45 PM - 3:15 PMJuha Kammonen, Neusentis, United Kingdom
HTS Electrophysiology - Validation Data for Voltage- and Ligand-gated Ion Channels
3:15 PM - 3:30 PM Break
Session IV, Chair: Jim Costantin 
3:30 PM - 4:00 PM Mat Brock, Axion Biosystems
Not Just for Safety: Phenotypic Disease Modeling and Optogenetics with Multielectrode Arrays
4:00 PM - 4:30 PM Ralf Kettenhofen, Axiogenesis AG, Germany
Human Cardiomyocytes Derived from iPS Cells: Assay Cascade for the Assessment of Cardiotoxicity
4:30 PM - 5:00 PM Timm Danker, NMI TT GmbH, Germany
A New Approach to Automated Patch Clamp Enabling Ultra-fast Compound Application and Optical Cell Selection
5:00 PM - 5:15 PM Closing Remarks, Jim Costantin 

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