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2013 Lecture Materials



SECTION I: THE CELL: SURVEY & PREVIEW
Lec 1. The cell as a basic unit of life's organization. (Z. Chen)
Lec 2. The cell interior as a tough neighborhood: Brownian motion and viscosity and their influence on particle motion in the cell. (
Z. Chen)

SECTION II: LIFE AND ENERGY
Lec 3. What is life? An attempt at definition. Energy, heat, and work: Temperature and thermal equilibrium. The First Law. Why do organisms need energy? (
B. Lentz)
Lec 4. Solutions and Chemical Potentials (
B. Lentz)
Lec 5. Mother Nature plays dice: the Boltzmann distribution, partition functions and entropy. (
B. Lentz)

SECTION III. NUCLEIC ACIDS AND GENETIC INFORMATION
Lec 6. Information Depository: Why a double helix? DNA Damage & Repair (
D. Ramsden)
Lec 7. DNA Replication and The End of the Chromosome: Aging, Cancer, and Drug Development (
M. Jarstfer)
Lec 8. How DNA is Packed in the Cell: Chromosomes, Genes, Nucleosomes (
B. Strahl)
Lec 9. Ribosomes: Machines that Synthesize Proteins (
J. Reader)

SECTION IV: PROTEIN STRUCTURE & FUNCTION
Lec 10. Proteins: ordered co-polymers that specifically bind other molecules to perform work of the cell (
R. Mendez)
Lec 11. The structural organization within proteins: primary, secondary, tertiary, and quaternary levels of organization; varieties of proteins: globular and fibrous. Pi Mol exercise (K. Slep)
Lec 12. Speeding things up: how enzymes work. (
C. Carter)
Lec 13. Proteins are not rigid structures: Protein dynamics/conformational variability. The stability of proteins as measured by free energy and denaturation. (
A. Lee)
Lec 14. Build your own Non-Random Polymers: Protein folding and protein design. (
B. Kuhlman)

SECTION V: CELL MEMBRANE STRUCTURE & FUNCTION
Lec 15. The Lipid Bilayer: A Dynamic Self-Assembled Structure of Multiple Lipid Classes. (S. Neher)
Lec 16. Membrane Proteins. (S. Neher)
Lec 17. Principles of Membrane Transport. (
G Meissner)
Lec 19. Membranes & Signal Transduction: GTPases. (
J. Sondek)

SECTION VI: MOTILITY
Lec 18. How Biological Motors Work: The Enzymology of Mechano-Chemical Energy Transduction (
C. Carter)
Lec 20. Stochastic Modeling of Molecular Motors (
D. Tsygankov)