The Bioenergetics Subgroup studies cellular and molecular processes associated with mitochondria, chloroplasts, and bacteria linked to metabolic energy transduction. Systems as varied as whole cells, intact organelles, membrane channels, carriers, and redox complexes might be used.
The Biological Fluorescence Subgroup focuses on the advance of knowledge pertaining to the development of new capabilities in fluorescence. Methodologies, both theoretical and experimental, and applications to derive structural and mechanistic understanding of biological systems can be involved.
Biopolymers in vivo
The purpose of the Biopolymers In Vivo subgroup is to create a forum to discuss biophysical properties and functions of biomolecules in cells and in cell-like environments, and the development of experimental and computational approaches to study these phenomena.
Exocytosis & Endocytosis
The Exocytosis & Endocytosis Subgroup promotes research on the molecular and cellular mechanisms of hormone and neurotransmitter release. This subgroup addresses the processes of membrane fusion and fission which are of crucial interest for intracellular membrane trafficking.
Intrinsically Disordered Proteins (IDP)
The IDP Subgroup seeks, through the use of biophysical and computational methods, to understand the physical basis for the biological roles of proteins, or protein regions that do not exhibit 3D structure in isolation under physiological conditions. Such proteins, or regions, are said to be intrinsically disordered.
Mechanobiology is an emerging area of biophysics that focuses on the role of mechanical cues that alter cellular responses and their transduction by cells. Topics ranging from rigidity sensing by stem cells to osmosensing in bacteria are all based upon mechanochemical processes. This new subgroup will call attention to how mechanical aspects of biological functions are critical for shaping organisms and influencing cellular processes at the molecular level. Cellular properties are not merely defined by their components, but how these components interact physically with one another and the cellular microenvironment over time.
The Membrane Biophysics Subgroup deals with the functional and regulatory mechanisms of ion transport across biological membranes.
Membrane Structure & Assembly
The Membrane Structure & Assembly Subgroup focuses on the biophysical properties of lipids, lipid assemblies, membrane proteins and lipid-protein interactions generally relevant to biological membranes and their assembly.
The Molecular Biophysics Subgroup investigates structures, conformational switching, responses to various imposed perturbations and deformational dynamics of biological macromolecules and their supramolecular assemblies. Measurements of thermodynamics and kinetics as well as uses of theoretical and computational methods for interpretation are addressed.
The Motility Subgroup focuses on the structure, function, and regulation of the motor protein families (myosin, kinesin and dynein) and on the protein tracks along which they move (actin filaments, microtubules) to generate muscle contraction, cell motility, and intracellular movement.
The Nanoscale Biophysics subgroup is interested in the study and control (manipulation) of biological, biocompatible, or bio-inspired matter on the scale of atoms and molecules. It is the melting pot for Nanoscale approaches ranging from theoretical to methodological studies, from advanced optical microscopy to scanning probe microscopy, from manipulation of single molecules to their imaging and tracking, from the understanding of mechanisms at the nanoscale to the design of new approaches, from molecular motors to new nanobiomaterials. So, let's think at the Nanoscale!
Permeation & Transport
The Permeation Transport Subgroup fosters the study of biophysical mechanisms of permeation and transport of small molecules and biopolymers through. cell membranes.