Recent discoveries in the field of polyglutamine (polyQ) protein aggregation research provide an example of how biophysics is involved in protein misfolding diseases like Huntington’s disease (HD). In this BPS networking event we bring together scientists from different continents, who look at polyQ from different biophysical and biological perspectives. We will explore ways to connect molecular biophysics (in vitro and in silico) to biological and cellular contexts, in order to help understand, and even treat, this kind of protein misfolding disease. The event offers a platform for networking and discussion of discipline-crossing challenges such as: - How can we integrate experimental and computational biophysics to understand polyQ protein aggregation and nucleation? - What (if any) structural features are carried from the nucleation event to the mature protein aggregates? - How do we understand and study these fundamentally biophysical processes in a biological context?