Lawrence Prochaska, Wright State University School of Medicine, Subgroup Chair

MORNING SYMPOSIUM: Calcium Signaling and Mitochondria

Co-Chairs: Gyorgy Hajnoczky, Thomas Jefferson University;
and Shey-Shing Sheu, University of Rochester Medical Center

9:00    David Clapham, Harvard University Medical School
            Control of Mitochondrial Calcium

9:30    Vamsi Mootha, Harvard University Medical School
            Comparative Genomics and Physiology of Mitochondria

10:00  Israel Sekler Ben-Gurion University of the Negev, Beersheva, Israel
            Not Just ATP; Identification and Physiological Role of the Mitochondrial                               Na+/Ca2+ Exchanger NCLX

10:30  Break

10:45  Heping (Peace) Cheng, Peking University, Peking, China
            Mitochondrial Superoxide Flashes

11:15  Gyorgy Szabadkai, University College, London, Great Britain
            Mitochondrial Determinants of Cellular Sensitivity to Cisplatin-Induced Cell                      Death

11:45  John LeMasters, Medical University of South Carolina
            Iron Uptake: A Rediscovered Role of the Mitochondrial Calcium Uniporter In                     Cell Injury

AFTERNOON SYMPOSIUM: Molecular System Bioenergetics: Combined Theoretical-Computational Approaches to the Analysis of Integrated Energetic-Signaling Networks

Co-Chairs: Miguel Aon, Johns Hopkins University School of Medicine;
and Uwe Schlattner, University of Grenoble, Grenoble, France

1:30     Young Bioenergeticist Award

1:45     Introductory Remarks

First Session: Energy and redox networks

2:00    Valdur Saks, University of Grenoble, Grenoble, France
            Quantitative Analysis of Integrated Energy Metabolism of Muscle Cells: Experimental and Theoretical Studies

2:30    Sonia Cortassa, John Hopkins University School of Medicine
            Dynamics of Mitochondrial Redox and Energy Networks: Insights From Experimental-computational Synergy

3:00    Jeffrey J. Saucerman, University of Virginia School of Medicine
            Imaging and Modeling Local cAMP Dynamics

3:30    Break

Second Session: Signaling networks

3:50    Ravi Lyengar, Mt. Sinai School of Medicine
            Dynamic Functions of Regulatory Motifs in Signaling Networks

4:20    Boris Kholodenko, University College, Dublin, Ireland
            Signaling Ballet in Four Dimensions

4:50   General Discussion

5:20    Subgroup Business Meeting including nominations for Chair and Council

7:00    Subgroup Dinner