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2026 Satellite Meeting
Drug Discovery for Ion Channels XXVI

Friday, February 20, 8:00 AM - 5:15 PM
Esplanade, Room 153, Moscone Center

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Early Registration is now closed. Onsite registrations will be accepted at the meeting.
Onsite Registration Fee: $250

Ion channels are an important class of therapeutic drug targets, and mutations in ion channel genes are found to be responsible for an increasing number of diseases.  While conventional electrophysiological techniques permit the most detailed and direct study of ion channel function, they are limited due to the manual nature of the method and their low throughput.  Because of this, ion channels remain an underrepresented target class for drug discovery. 

The advent of higher throughput automated electrophysiology systems changed the face of ion channel drug discovery.  Since the inaugural “Drug Discovery for Ion Channels” satellite meeting, there have been many advances in ion channel drug discovery including new instrumentation and techniques.  For this year, we propose to continue the “Satellite Meeting” tradition at the Biophysical Society Annual Meeting and review the advances ion channel drug discovery. 

This year’s meeting will highlight presentations from drug discovery companies, companies that provide ion channel services to drug discovery companies and companies that provide products to ion channel drug discovery companies, as well as other speakers in the field of ion channel drug discovery, including several academic speakers.  
 

8:00 AM

Registration and Coffee
8:30 AM Niels Fertig, Nanion, Germany
Welcome and Opening Remarks
Session I Niels Fertig, Nanion, Germany, Chair
8:45 AM - 9:30 AM KEYNOTE - Ramon Latorre, University of Valparaíso, Chile
Sensing Voltage in BK Channels: A Tale of Two Sensors
9:30 AM - 10:00 AM Henry Colecraft, Columbia University, USA
Revisiting Ion Channel Regulation by NEDD4 Family E3 Ligases
10:00 AM - 10:30 AM Ivy Dick, University of Maryland, USA
Diverse Mechanisms in the Pathogenesis of Calcium Channelopathies

10:30 AM - 11:00 AM

Coffee Break
Session II Jean-Francois Rolland, Axxam, Italy, Chair
11:00 AM - 11:30 AM Tianbo Li, Genentech, USA
Distinct Mechanism of Activating Lysosome Ion Channel TMEM175
11:30 AM - 12:00 PM Heike Wulff, University of California, Davis, USA
Virtual Screening for Modulators of KCa, GABAA and Nav1.7 channels
12:00 PM - 12:30 PM Esteban Suarez Delgado, Xenon Pharmaceuticals, Canada
Selective Potentiation of Nav1.1 Channels in a Model of Dravet Syndrome
12:30 PM - 1:30 PM Lunch
Session III

Eugenia Jones, FujiFilm Cellular Dynamics (FCDI), USA, Chair

1:30 PM - 2:00 PM

Victoria Assimon, Maze Therapeutics, USA
Navigating the Maze of APOL1 Genetics to Develop New Precision Medicines for Kidney Disease

2:00 PM - 2:30 PM Rajesh Khanna, Center for Advanced pain Therapeutics and Research at the University of Florida, USA
Decoding the Molecular QR Code of Pain: From Mechanism to Therapeutic Translation
2:30 PM – 3:00 PM David Adams, University of Wollongong, Australia
GABAB Receptor-mediated Modulation of Sensory Neuron Excitability: Roles of CaV2.2, GIRK, and HCN Channels in Nociception
3:00 PM - 3:30 PM Coffee Break
Session IV Derek Hernandez, Ion Biosciences, USA, Chair
3:30 PM - 400 PM Saverio Gentile, Medical University of South Carolina, USA
Drugging Bioelectric Stress: Ion Channels as Gatekeepers of Redox Collapse and Tumor Suppression
4:00 PM - 4:30 PM Anna Moroni, University of Milan, Italy
Extracellular Activation of HCN4 by a Subtype-specific Nanobody
4:30 PM - 5:00 PM Markus Delling, University of California, San Francisco, USA
Functional Characterization of Missense Mutations in Polycystin Channels Reveal New Therapeutic Avenues for ADPKD
5:00 PM - 5:15 PM Daniel Sauter, Sophion Bioscience, USA
Closing Remarks
Sponsored by: