Sunday, October 5, 2025
5:00 PM - 8:30 PM
Registration
7:00 PM - 7:10 PM
Ling-Gang Wu, NIH, USA
Welcome and Opening Remarks
Session I: Presynapse Formation, Functions, and Partial Release
7:10 PM - 7:35 PM
Robert Edwards, USCF Weill Institute for Neuroscience, USA
A Presynaptic Form of Homeostatic Plasticity
7:35 PM - 8:00 PM
Andrew Ewing, University of Gothenburg, Sweden
Title TBD
8:00 PM - 8:45 PM
Volker Haucke, Leibniz-FMP, Germany
Plenary Talk: How the Presynapse Forms and Functions
9:10 PM - 10:30 PM
Social Gathering
Monday, October 6, 2025
7:30 AM - 8:30 AM
Breakfast
8:00 AM - 4:00 PM
Registration
Session II: Endocytic Protein Mechanisms and Functions
8:30 AM - 8:55 AM
Juan S. Bonifacino, NICHD-NIH, USA
Sorting Functions of the Non-Clathrin Coat AP-4
8:55 AM - 9:20 AM
Jihong Bai, Fred Hutch Cancer Center, USA
Synaptic Vesicle Endocytosis: Roles of Amphipathic Motifs
9:20 AM - 9:45 AM
Avital Rodal, Brandeis University, USA
Distinct and Overlapping Functions of Drosphila Dynamin PRD Isoforms
9:45 AM - 10:00 AM
Feng-Ching Tsai, Curie Institute, France*
Asymmetric Branches Actin Assembly Driven by N-Wasp Around a Membrane Neck Leads to Neck Breakage
10:00 AM - 10:15 AM
Richard Baker, University of North Carolina Chapel Hill, USA*
CCDC32 Co-Opts Both Cargo Binding Sites to Mediate Assembly of the AP-2 Clathrin Adaptor Complex
10:15 AM - 10:45 AM
Coffee Break
Session III: Exocytosis: Protein Functions and Fusion Pore Structure
10:45 AM - 11:10 AM
Jacqueline Burré, Cornell Medical College, USA
Molecular Mechanisms Underlying Disease-Causing Mutations in SNAP-25
11:10 AM - 11:35 AM
Jiajie Diao, University of Cincinnati, USA
MUNC18 Modulates Syntaxin Phase Separation for Exocytosis
11:35 AM - 12:00 PM
Volker Kiessling, University of Virginia, USA
Insights into the Lipid-Protein and Protein-Protein Interactions Guiding Snare Mediated Membrane Fusion
12:00 PM - 12:25 PM
Frederic Meunier, University of Queensland, Australia
Building the Fusion Pore at the Nanoscale: A Sisyphean View
12:25 PM - 1:30 PM
Lunch
Session IV: Virus Entry and Budding
1:30 PM - 1:45 PM
Sun Han, NINDS-NIH, USA*
Constitutive Macropinocytosis is the Major Entry Pathway of SARS-COV-2
1:45 PM - 2:10 PM
Schuyler van Engelenburg, University of Denver, USA
Pushing the Envelope of Superresolution Microscopy to Study Enveloped Virus Budding
2:10 PM - 2:35 PM
Nihal Altan-Bonnet, NIH, USA
SARS-COV-2 Mediated Lysosome Dysfunction Modulates Natural Killer Cell Responses
2:35 PM - 4:00 PM
Poster Session I
4:45 PM - 7:30 PM
Free Time/Dinner on Own
Session V: Synaptic Vesicle Recycling, Plasticity and Neurological Disorders
7:30 PM - 7:55 PM
David DiGregorio, University of Colorado School of Medicine, USA
Title TBD
7:55 PM - 8:20 PM
Nils Brose, Max Planck Institute for Multidisciplinary Sciences, Germany
Vesicle Priming and Synaptic Short-Term Plasticity - Mechanisms and Functions in Health and Disease
8:20 PM - 9:10 PM
Timothy Ryan, Cornell Medical College, USA
Plenary Talk: Synaptic Vesicle Recycling: A Metabolic Vulnerability Associated with Neurodegeneration
9:10 PM - 10:30 PM
Social Gathering
Tuesday, October 7, 2025
7:30 AM - 8:30 AM
Breakfast
8:00 AM - 4:00 PM
Registration
Session VI: Synaptic Vesicle Exocytosis and Endocytosis
8:30 AM - 8:55 AM
Jason Vevea, St. Judes Children's Research Hospital, USA
Age-Dependent Molecular Changes in the Synaptic Vesicle
8:55 AM - 9:20 AM
Wallace B. Thoreson, University of Nebraska Medical Center, USA
Glutamate Release at Ribbon Synapses of Rod Photoreceptor Cells
9:20 AM - 9:45 AM
Henrique von Gersdorff, OHSU Vollum Institute, USA
Ultrafast Endocytosis at an Inhibitory Synapse
9:45 AM - 10:00 AM
Dennis Weingarten, OHSU Vollum Institute, USA*
Synaptotagmin-3 and -7 Dynamically Regulate the Readily Releasable Pool
10:00 AM - 10:15 AM
Grant Walters, Vanderbilt University, USA*
ATP Dependent Regulation of Spontaneous Neurotransmission
10:15 AM - 10:45 AM
Coffee Break
Session VII: Synaptotagmin Functions and Virus Infection
10:45 AM - 11:10 AM
Jeff Knight, University of Colorado, Denver, USA
Carbonyl Reactivity of Synaptotagmins and Related Secretory Pathway Proteins
11:10 AM - 11:35 AM
Noreen Reist, Colorado State University, USA
Synaptotagmin in Health and Disease
11:35 AM - 12:00 PM
Shyam Krishnakumar, Yale University, USA
Mechanistic Dissection of Synaptic Fusion Dynamics Mediated by Synaptotagmin Isoforms
12:00 PM - 12:25 PM
Tijana Ivanovic, NIH, USA
Title TBD
12:25 PM - 1:30 PM
Lunch
Session VIII: Fusion Pore and Release Regulation
1:30 PM - 1:45 PM
H. Robe Guy, Amyloid Research Consultant, USA*
Amyloid Beta 42 Mechanosensitive Sieve Models of Fusion Pores
1:45 PM - 2:10 PM
Debasis Das, Tata Institute of Fundamental Research, India
Role of Fusion Pores in Quantal Size Variation - Implications in Cellular Plasticity?
2:10 PM - 2:35 PM
Heidi Hamm, Vanderbilt University, USA
Title TBD
2:35 PM - 4:00 PM
Poster Session II
4:45 PM - 7:30 PM
Free Time/Dinner on Own
Session IX: Mechanical Forces and Molecular Mechanisms for Vesicle Formation and Fission
7:30 PM - 7:55 PM
Jürgen Klingauf, University of Münster, Germany
Title TBD
7:55 PM - 8:20 PM
Rajesh Ramachandran, Case Western University, USA
Title TBD
8:20 PM - 9:10 PM
David Drubin, University of California, Berkeley, USA
Plenary Talk: Harnessing Actin Assembly Forces for Endocytic Vesicle Formation
9:10 PM - 10:30 PM
Social Gathering
Wednesday, October 8, 2025
7:30 AM - 8:30 AM
Breakfast
8:00 AM - 4:00 PM
Registration
Session X: Mitochondria and Golgi Membrane Dynamics
8:30 AM - 8:55 AM
Ya-Wen Liu, National Taiwan University College of Medicine, Taiwan
Lipid Logic: How Cardiolipin Conversion Enables Selective Mitochondrial Fusion
8:55 AM - 9:20 AM
Debbie C. Thurmond, City of Hope, USA
Beyond Exocytosis: Snare-Mediated Hijacking at the Mitochondria
9:20 AM - 9:45 AM
Halil Aydin, NYU Pain Research Center, New York University, USA
Cardiolipin Dynamics Promote Mitochondrial Membrane Remodeling
9:45 AM - 10:00 AM
Chase Amos, Yale University, USA*
The Bridge-Like Lipid Transfer Protein VPS13D Controls Membrane Dynamics at the Trans Golgi/TGN
10:00 AM - 10:15 AM
Maohan Su, Yale University*
Golgi Stack Is Organized by a Precise Tetraplex of Rim Golgin Proteins
10:15 AM - 10:45 AM
Coffee Break
Session XI: Lipid Functions in Protein Assembly and Pore Formation
10:45 AM - 11:10 AM
Sarah Veatch, University of Michigan, USA
Lipids Facilitate Protein Assembly at Membranes Through Prewetting
11:10 AM - 11:35 AM
Huan Bao, University of Virginia School of Medicine, USA
Designer Nanodiscs to Probe and Reprogram Membrane Fusion and Pore Formation
11:35 AM - 12:00 PM
Tamas Balla, NICHD-NIH, USA
Membrane Lipid Composition Guides the Assembly of Membrane Shaping Proteins
12:00 PM - 12:25 PM
Itay Budin, University of California, San Diego, USA
Title TBD
12:25 PM - 1:30 PM
Lunch
Session XII: Fusion, Fission, Membrane Contact, and Cell Migration
1:30 PM - 1:45 PM
Weonika Tomaka, University of Virginia, USA*
MUNC18 and Membrane Lipids Cooperate to Regulate the Lateral Distribution of Syntaxin-1A in the Plasma Membrane
1:45 PM - 2:10 PM
Matthew Brody, University of Michigan Medical School, USA
Regulation of Atrial Natriuretic Peptide Secretion by the Rab3 Cycle
2:10 PM - 2:35 PM
Anna Shnyrova, Biofisika Institute, Spain
Fusion Mediated by a Fission Protein Machinery
2:35 PM - 4:00 PM
Poster Session III
4:45 PM - 7:30 PM
Free Time/Dinner on Own
Session XIII: Ultrafast Endocytosis, Dense-Core Vesicle Fusion and Neuronal Endosome-Lysosome
7:30 PM - 7:55 PM
Michael B. Hoppa, Dartmouth University, USA
KV2-Mediated Presynaptic Er/Pm Junctions Organize Calcium Signaling and Regulate Vesicle Fusion
7:55 PM - 8:20 PM
Hanaa Hariri, Wayne State University, USA
Mechanistic Principles of Metabolic Organization at Membrane Contact Sites
8:20 PM - 8:45 PM
Lois Weisman, University of Michigan, USA
Pikfyve Promotes Cell Migration Via Control of a Negative Regulator of RAC1
8:45 PM - 9:10 PM
Erik Jorgensen, University of Utah, USA
Title TBD
Thursday, October 9, 2025
7:30 AM - 8:30 AM
Breakfast
8:00 AM - 3:30 PM
Registration
Session XIV: Dense-Core Vesical Fusion and Neuronal Endosome-Lysosome
8:30 AM - 8:55 AM
Bettina Winckler, University of Virginia, USA
Endosomes and Lysosomes in Neurons: What Happens When They Break?
8:55 AM - 9:20 AM
Cedric Asensio, University of Denver, USA
Title TBD
9:20 AM - 9:45 AM
Julie Brill, Hospital for Sick Children, Canada
Making a Granule: How PI4KII and OSBP Regulate Secretory Granule Maturation
9:45 AM - 10:00 AM
Quanfeng Zhang, Peking University, China*
Tuning the Size of Large Dense‐Core Vesicles and Quantal Neurotransmitter Release via Secretogranin II Liquid–Liquid Phase Separation
10:00 AM - 10:15 AM
Anuma Pallavi, Indian Institute of Science, India*
Glut Trafficking and Glucose Sensing Coordinate Insulin Secretion in Pancreatic Cells: A Dysfunctional Axis in Diabetes
10:15 AM - 10:45 AM
Coffee Break
Session XV: Cryo-EM and -ET of Synapses, Clathrin, Dynamin, and Ferrosome
10:45 AM - 11:10 AM
John R. Jimah, Princeton University, USA
Title TBD
11:10 AM - 11:35 AM
Axel Brunger, Stanford University, USA
Architecture of Synapses Revealed by Cryo-Electron Tomography
11:35 AM - 12:00 PM
Qiangjun Zhou, Vanderbilt University, USA
Molecular Mechanism for Ferrosome Formation
12:00 PM - 12:15 PM
Kem Sochacki, NHLBI-NIH, USA*
Cryo-Electron Tomography of Clathrin Structures on Eukaryotic Plasma Membranes
12:15 PM - 12:30 PM
Nidhi Kundu, NIDDK-NIH, USA*
Cryo-EM Structures of Dynamin Mimicking Conformational States of Membrane Fission During Endocytosis
12:30 PM - 1:30 PM
Lunch
Session XVI: Synaptic Vesicle Exocytosis: Lipid Regulation and Suspended Bilayer Platform
1:30 PM - 1:55 PM
Sathish Ramakrishnan, Yale School of Medicine, USA
Title TBD
1:55 PM - 2:20 PM
Min Ju Shon, Pohang University of Science and Technology, South Korea
Title TBD
2:20 PM - 2:45 PM
Yongli Zhang, Yale University, USA
Mechanisms of Synaptic Vesicle Fusion and Bulk Lipid Transport
3:10 PM - 4:00 PM
Reinhard Jahn, University of Göttingen, Germany
Plenary Talk: SNARE-Mediated Membrane Fusion - Where Are the Energy Barriers?
4:00 PM - 4:15 PM
Michelle Knowles, University of Denver, USA
Closing Remarks and Biophysical Journal Poster Awards
4:15 PM - 6:00 PM
Free Time
6:00 PM - 8:00 PM
Banquet Dinner
* Contributed talks selected from among submitted abstracts