Sunday, November 9, 2025
16:00 – 18:00
Registration/Information
18:00 – 19:30
Welcome Reception
Monday, November 10, 2025
08:30 – 18:00
Registration/Information
08:50 – 09:00
Matthias Buck, Case Western Reserve University, USA & Zoe Cournia, Biomedical Research Foundation, Academy of Athens, Greece
Welcome & Opening Remarks
Session I: Membrane Interaction of Kinases
Chair: Alemayehu Gorfe, University of Texas Health Science Center at Houston, USA
09:00 – 09:30
Kalina Hristova, Johns Hopkins University, USA
Biophysics of Growth Factor Receptor Organization and Signaling in the Membrane
09:30 – 10:00
Adam Smith, Texas Tech University, USA
Anionic Lipids Inhibit the Catalytic Activity of the Membrane Proximal EGFR Kinase Domain
10:00 – 10:20
Matthias Buck, Case Western Reserve University, USA
Plexin and EPH Receptors: The View
10:20 – 10:50
Coffee Break
10:50 – 11:20
Daniel Abankwa, University of Luxembourg, Luxembourg
SPRY2 Interacts with Active RAS to Modulate Its Membrane Organization
11:20 – 11:50
Helgi Ingolfsson, Lawrence Livermore National Laboratory, USA
Capturing Lipid-Protein Interactions During RAS-RAF Activation Using Machine Learning-Driven Multiscale Simulations
11:50 – 12:10
Rachel McAllister, Yale University, USA *
Novel Two-Step Peripheral Membrane Recruitment Mechanism of Bruton's Tyrosine Kinase Through Native Mass Spectometry
12:10 – 13:10
Lunch
Session II: Membrane Remodeling
Chair: Themis Lazardis, The City College of New York, USA
13:10 – 13:40
Patricia Bassereau, Institute Curie, France
A Minimal Human ESCRT-III System to Mimic HIV-1 Detachment
13:40 – 14:10
Winfried Weissenhorn, Institute of Sturctural Biology, France
Constricting and Cleaving Membrane Necks with ESCRT-III and VPS4
14:10 – 14:30
Dirk Schneider, Johannes Gutenberg University, Germany *
Membrane Interaction of a Prokaryotic ESCRT-III Protein
14:30 – 16:00
Coffee Break / Poster Session I
16:00 - 16:30
Phillip Stansfeld, University of Warwick, United Kingdom
Modelling Lipid Interactions at Membrane Interfaces with MEMPRO and CCD2MD
16:30 – 17:00
Anne Kenworthy, University of Virginia, USA
Controlling Cells from Deep Inside the Membrane: The Case of Caveolins
17:00 – 17:20
Korbinian Liebl, Technical University of Munich, Germany *
Membrane Remodeling by the Collective Action of Caveolin-1
17:20 – 18:00
Round Table Discussions
Tuesday, November 11, 2025
08:30 – 18:00
Registration/Information
Session III: Protein Membrane Interfaces and Membrane Lipid Composition
Chair: Matthias Buck, Case Western Reserve University, USA
09:00 – 9:30
Karen Fleming, Johns Hopkins University, USA
Energetics of Side Chain Partitioning Across the Bilayer Interface
09:30 – 10:00
Linda Columbus, University of Virginia, USA
Impact of Membrane Compositions on Bacterial Membrane Protein Structure, Dynamics, and Function
10:00 – 10:20
Kirill Grushin, Yale University, USA *
Structural Insights into Munc13-1 Self-Assemblies on Lipid Bilayers from Cryo-Electron Tomography
10:20 – 10:50
Coffee Break
10:50 – 11:20
Francisco Barrera, University of Tennessee at Knoxville, USA
The Journey to the Membrane of Candidalysin, Step-By-Step
11:20 – 11:50
Xiaolin Cheng, The Ohio State University, USA
Integrative Modeling of Sterol Recognition by the SCAP Protein
11:50 – 12:10
Alexandre Chenal, Institute Pasteur, France *
Structure and Membrane Translocation Process of the Bordetella Pertussis CYAA Toxin
12:10 – 13:10
Lunch
Session IV: Transporters, Etc.
Chair: Zoe Cournia, Biomedical Research Foundation, Academy of Athens, Greece
13:00 – 13:40
Phil Biggin, University of Oxford, United Kingdom
From Sequence to Mechanism: Insights into Proton Coupling in Cystinosin from Multiscale Molecular Simulations
13:40 – 14:10
Marco De Vivo, Italian Institute of Technology, Italy
Decoding Biochemical Complexity with Simulations and AI-Enhanced Sampling
14:10 – 14:30
Vinodhini Selvanayanaran, Indian Institute of Sciences, Bengaluru, India *
Divergent Breathings Modes of EHD Paralogs: Insights from Molecular Simulations and Implications in Membrane Remodeling
14:30 – 16:00
Coffee Break/Poster Session II
16:00 – 16:30
Paolo Carloni, Forschungszentrum Julich GmbH, Germany
Multiscale, ML-Assisted Simulations on Neuronal Membrane Proteins
16:30 – 17:00
Nir Ben-Tal, Tel Aviv University, Israel
An AI-Based Holistic View of the Protein Universe
17:00 – 17:30
Anna Shnyrova Zhadan, University of the Basque Country, Spain
Membrane Fusion Mediated by Classical Dynamin Machinery
17:30 – 18:00
Round Table Discussions
Wednesday, November 12, 2025
08:30 – 13:00
Free Time / Lunch on Own
13:00 – 18:00
Registration/Information
Session V: Inhibitors Targeting Membrane Proteins and Protein-Membrane Interfaces
Chair: Matthias Buck, Case Western Reserve University, USA
13:30 – 14:00
Ivet Bahar, Stony Brook University, USA
Ferroptotic Interactions of Peripheral membrane Proteins with Small Molecules
14:00 – 14:30
Zoe Cournia, Biomedical Research Foundation, Academy of Athens, Greece
Describing Protein Conformational Landscapes at the Protein-Membrane Interface: Implications for Drug Design
14:30 – 14:50
Peter Chung, University of Chicago, USA *
Deciphering the Organelle-Targeting Specificity of Inducible Amphipathic Helices Through a Recombinant Protein Platform
14:40 – 15:20
Round Table Discussions
15:20 – 15:50
Alemayehu Gorfe, Univeristy of Texas Health Science Center at Houston, USA
Characterizing the Membrane Orientation Dynamics of RHEB and Its Functional Consequences
15:50 – 16:20
Matteo Dal Peraro, EPFL, Switzerland
Unraveling the Mechanistic Diversity of Peripheral Proteins Binding to Membranes Through Integrative Approaches
16:20 – 16:40
Diomedes Logothetis, Northeastern University, USA *
Structural Biology Structural Understanding of G Protein GA3NG of K+ Channels in Brain and Heart
16:40 – 18:30
Free Time
18:30 – 20:30
Banquet Dinner at Electra Palace Hotel
Thursday, November 13, 2025
08:30 – 15:00
Registration/Information
Session VI: Endo-Membrane Proteins
Chair: Alemayehu Gorfe, University of Texas Health Science Center at Houston, USA
09:00 – 09:30
Antoine Taly, CNRS, France
Prediction of A. Thaliana's MCTP Structure, Embedding in the Endoplasmic Reticulum and Interaction with the Plasma Membrane
09:30 – 10:00
Nathalie Reuter, University of Bergen, Norway
Membranes as Allosteric Effectors for Lipid Transfer Proteins
10:00 – 10:20
Mahmoud Moradi, University of Arkansas, USA *
Molecular Dynamics Study of Sphingosine Kinase 1 (SK1) Regulation at the Membrane Interface
10:20 – 10:50
Coffee Break
10:50 – 11:20
Stephano Vanni, University of Fribourg, Switzerland
Peripheral Proteins as Master Regulators of Membrane Organization and Composition
11:20 – 11:50
Themis Lazaridis, City College of New York, USA
Curvature Generation by the Caveolin 8S Complex
12:30 – 12:45
Dylan Suriadinata, Texas A&M University, USA *
Bridging Protein TTR-53 Mediates Phophatidylinositol Phosphate Signaling for Cell Corpse Clearance
12:10 – 12:30
Round Table Discussions
12:30 – 13:30
Lunch
Session VII: Receptors, Channels, and Translocators
Chair: Zoe Cournia, Biomedical Research Foundation, Academy of Athens, Greece
13:30 – 14:00
Maria Kurnikova, Carnegie Mellon University, USA
Conformational Ensembles and Conductivity Modeling in Tetrameric Ion Channel Receptors
14:00 – 14:30
Syma Khalid, University of Oxford, United Kingdom
Computational Microbiology: Multiscale Simulations of Membrane Active Peptides
14:30 – 14:50
Agata Witkowska, FMP, Germany *
Mechanical Control of Neurotransmission via a Disordered Domain of an Endocytic Protein
14:50 – 15:00
Alemayehu Gorfe, University of Texas Health Science Center at Houston, USA & Themis Lazaridis, City College of New York, USA
Closing Remarks
*Short talks selected from among submitted abstracts