Sunday, August 3, 2025
3:00 PM – 6:00 PM
Registration
4:50 PM – 5:00 PM
Welcome and Opening Remarks
Elena E. Pohl, University of Veterinary Medicine Vienna, Austria
Gregory Voth, University of Chicago, USA
5:00 PM – 6 :00 PM
Plenary Talk
Gregory Voth, University of Chicago, USA, Chair
Robert Stroud, University of California, San Francisco, USA
The Conundrum of How and When Proton(s) Drive Transport?
6:00 PM – 7:30 PM
Dinner
Session I: Multiscale Aspects of Proton Transport
Emily Liman, University of Southern California, USA, Chair
7:30 PM – 8:00 PM
Jessica Swanson, University of Utah, USA
Multiscale Responsive Kinetic Modeling of Proton-Coupling in Ion Channels and Transporters
8:00 PM – 8:30 PM
Alexey Amunts, The Max Planck Institute of Molecular Physiology, Germany
Coupling of Bioenergetic Electron Transport with Proton Dynamics
8:30 PM – 10:00 PM
Get Together (Wine & Cheese)
Monday, August 4, 2025
7:30 AM - 8:30 AM
Breakfast
8:00 AM – 12:30 PM
Registration
Session II: Proton Transport in Mitochondria
Leonid Sazanov, Institute of Science and Technology, Austria, Chair
9:00 AM – 9:30 AM
Mario Vazdar, University of Chemistry and Technology in Prague, Czech Republic
Molecular Dynamics Simulations of Proton Transfer in Mitochondrial Uncoupling Proteins
9:30 AM – 10:00 AM
Elena E. Pohl, University of Veterinary Medicine Vienna, Austria
Understanding the Molecular Mechanism of Mitochondrial Uncoupling induced by 2,4-Dinitrophenol
10:00 AM – 10:30 AM
Vivek Sharma, University of Helsinki, Helsinki, Finland *
Thermodynamics and Kinetics of Proton Transfer Reactions Catalyzed by Respiratory Complex
10:30 AM – 10:45 AM
Md. Raihan Uddin, Department of Biochemistry, NY, USA *
Proton Pumping Mechanism of Photosynthetic NDH-1 and Complex I
10:45 AM – 11:15 AM
Coffee Break
Session III: Transporters
Peter Pohl, Johannes Kepler University Linz - JKU, Austria, Chair
11:15 AM – 11:45 AM
Simon Newstead, University of Oxford, United Kingdom
Understanding the Role of Protons in Drug Transport Via SLC15A2
11:45 AM – 12:00 PM
Zhi Yue, University of Chicago, USA*
Protons Enable Calcium Passage through the Hydrophobic Channel in the SARS-CoV-2 Envelope Protein
12:00 PM – 12:15 PM
Jonathan D Colburn, University of Oxford, United Kingdom *
From Sequence to Mechanism: Insights into Proton Coupling in Cystinosin from Multiscale Molecular Simulations
12:30 PM – 1:30 PM
Lunch
1:30 PM – 5:30 PM
Hiking/Interactions
5:30 PM – 6:30 PM
Dinner
Session IV: Light Driven Proton Transport
Satoshi Tsunoda, Nagoya Institute of Technology, Japan, Chair
6:30 PM – 7:00 PM
Peter Pohl, Johannes Kepler University Linz, Austria
Phototriggered Proton-Selective Carrier Currents
7:00 PM – 7:30 PM
Noam Agmon, The Hebrew University of Jerusalem, Israel *
Multi-Proton Dynamics Near Membrane-Water Interface
7:30 PM – 8:00 PM
Yoshitaka Kato, University of Tokyo, Japan *
Proton Transport Mechanism of Newly Discovered Light-Driven Inward Proton Pump, ELTxer
8:00 PM – 10:00 PM
Poster Session I (Wine & Cheese)
Tuesday, August 5, 2025
7:00 AM – 8:30 AM
Breakfast
8:00 AM – 12:30 PM
Registration/Information
Session V: Voltage-gated Proton Channels
Jessica Swanson, University of Utah, USA, Chair
9:00 AM – 9:30 AM
Thomas DeCoursey, Rush University Medical Center, USA
Dissecting the Signature Sequence of the Voltage-gated Proton Channel
9:30 AM – 10:00 AM
Boris Musset, Paracelsus Medical University, Austria
Somatic Cancer Mutations in the S4 Transmembrane Segment of the Human Voltage-Gated Proton Channel HV1
10:00 AM – 10:30 AM
Akira Kawanabe, Hiroshima University, Japan
The Functional Regulation of the Voltage-Gated Proton Channel by ATP
10:30 AM – 10:45 AM
Gustavo Chaves, Paracelsus Medical University, Nuremberg, Germany *
Exploring Biophysical Divergences within the Voltage-Gated Proton Channel (Hv) Family
10:45 AM – 11:15 AM
Coffee Break
Session VI: Proton Pump Rhodopsins
Rubin Liang, Texas Tech University, USA, Chair
11:15 AM – 11:45 AM
Satoshi Tsunoda, Nagoya Institute of Technology, Japan
Driving Force of Various Proton Pump Rhodopsins
11:45 AM – 12:15 PM
Keiichi Inoue, University of Tokyo, Japan
Proton Transfer in the Photocyclic Reaction of Ion-Transporting Microbial Rhodopsins
12:15 PM – 12:30 PM
Masaki Tsujimura, University of Tokyo, Japan and RIKEN Pioneering Research Institute, Wako, Japan *
Converting a Chloride-Pumping Rhodopsin into a Proton Pump
12:30 PM – 1:30 PM
Lunch
1:30 PM – 5:30 PM
Hiking/Interactions
5:30 PM – 6:30 PM
Dinner
Session VII: Proton Transport: Physiology and Disease
Simon Newstead, University of Oxford, United Kingdom, Chair
6:30 PM – 7:00 PM
Joseph Mindell, NINDS, NIH, USA
Mechanisms of Novel Diseases Disrupting Lysosomal Via ClC-7 Chloride Transporter Mutations
7:00 PM – 7:30 PM
Emily Liman, University of Southern California, USA
Targeting OTOP Proton Channels: Insights from Chemical Modulators
7:30 PM – 7:45 PM
Daniel R. Sauter, Sophion Bioscience Inc., San Diego, USA *
Automated Patch Clamp Assay for Proton-Activated HOTOP1 Channel
8:00 PM – 10:00 PM
Poster Session II (Wine & Cheese)
Wednesday, August 6, 2025
7:00 AM – 8:30 AM
Breakfast
8:00 AM – 12:30 PM
Registration/Information
Session VIII: Origins and Effects of Proton Transport in Proteins
Qiang Cui, Boston University, USA, Chair
9:00 AM – 9:15 AM
James Lee, Old Dominion University, USA
Transmembrane-Electrostatically Localized Protons/Cations in Mitochondria and Neurons
9:15 AM – 9:30 AM
Jiahua Deng, Princeton University, USA
Role of A Tryptophan in Proton-Coupled Electron Transport in Ribonucleotide Reductase
9:30 AM – 10:00 AM
Ana-Nicoleta Bondar, University of Bucharest, Romania
Water- And Lipid-Mediated Hydrogen-Bond Networks of pHD Peptide Pores
10:00 AM – 10:30 AM
Huong Kratochvil, University of North Carolina at Chapel Hill, USA
Modulating Proton Transport Through Designed Hydrogen-Bonding Networks
10:30 AM – 10:45 AM
Merissa Brousseau, University of Wisconsin-Madison, USA *
Beyond Peak Currents: Solid-Supported Membrane Electrophysiology as a Means of Investigating Universal Transport Model
10:45 AM – 11:15 AM
Coffee Break
Session IX: Effect of Lipid Membranes on Proton Transport
Noam Agmon, Hebrew University of Jerusalem, Israel, Chair
11:15 AM – 11:45 AM
Jochen Hub, Saarland University, Germany
How Complex Lipid Compositions Control Mechanical Stability of Biomembranes
11:45 AM – 12:00 PM
Ambili Ramanthrikkovil Variyam, Technion - Israel Institute of Technology, Israel *
Proton Diffusion on the Surface of Mixed Lipid Membranes Highlights the Role of Membrane Composition
12:00 PM – 12:15 PM
Shizhen Wang, University of Missouri-Kansas City, Kansas City, USA *
Regulation of Proton Transport by Membrane Sterols
12:30 PM – 1:30 PM
Lunch
1:30 PM – 5:30 PM
Hiking/Interactions
5:30 PM – 6:30 PM
Dinner
Session X: Proton Transport Mechanisms
Gregory Voth, University of Chicago, USA, Chair
6:30 PM – 7:00 PM
Qiang Cui, Boston University, USA
Exploring the Mechanism of Ion Conduction Through Protein E of SARS-CoV-2
7:00 PM – 7:30 PM
Katharine White, University of Notre Dame, USA
Regulating Proteins, Pathways, and Cell Behaviors
7:30 PM – 8:00 PM
Rubin Liang, Texas Tech University, USA
Decrypting the Non-Adiabatic Photoinduced Electron Transfer Mechanism in Light-Sensing Cryptochrome
8:00 PM – 10:00 PM
Poster Session III (Wine & Cheese)
Thursday, August 7, 2025
7:00 AM – 8:30 AM
Breakfast
8:00 AM – 12:30 PM
Registration/Information
Session XI: Proton Transport Tied to Structure
Ana-Nicoleta Bondar, University of Bucharest, Romania, Chair
9:00 AM – 9:30 AM
Marylin Gunner, City College of New York, USA
Coupled protonation states and hydrogen bond networks in proton pumps
9:30 AM – 10:00 AM
Kota Katayama, Nagoya Institute of Technology, Japan
Structural Insights into Spectral Tuning from the Three-Dimensional Structures of Red and Green Cone Pigments
10:00 AM – 10:15 AM
Ruchika Bajaj, University of California, San Francisco *
Understanding ABC Transporters to Navigate Human Diseases
10:45 AM – 11:15 AM
Coffee Break
Session XII: Modelling of Charge Transport
Mario Vazdar, University of Chemistry and Technology in Prague, Czech Republic, Chair
11:15 AM – 11:45 AM
Gregory Voth, University of Chicago, USA
Advances in Modeling Transmembrane Proton Transport in Biomolecular Systems
11:45 AM – 12:00 PM
Jong Ho Choi, University of Chicago, USA
Water Connectivity and its Cooperative Coupling to Proton Transport in A Key Region Of Complex I
12:00 PM – 12:15 PM
Chang Yun Son, Seoul National University, South Korea *
Modeling Classical and Quantum Charge Transport in Large Scale with Stochastic Λ-Dynamics
12:15 PM – 1:30 PM
Lunch
1:30 PM – 6:00 PM
Hiking/Interactions
6:00 PM – 7:00 PM
Dinner
7:00 PM – 8:00 PM
Plenary Talk
Elena E. Pohl, University of Veterinary Medicine Vienna, Austria, Chair
Leonid Sazanov, Institute of Science and Technology Austria
The Mechanism of Proton Translocation by Respiratory Complex I
8:00 PM – 8:15 PM
Closing Remarks Biophysical Journal Poster Awards
Elena E. Pohl, University of Veterinary Medicine Vienna, Austria
Gregory Voth, University of Chicago, USA
8:15 PM – 10:00 PM
Open Discussion to all Topics & Executive Meeting (Wine & Cheese)
* Contributed talks selected from among submitted abstracts