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Sunday, August 3, 2025

3:00 PM – 6:00 PM
Registration

4:50 PM – 5:00 PM
Welcome and Opening Remarks
Elena E. Pohl, University of Veterinary Medicine Vienna, Austria
Gregory Voth, University of Chicago, USA

5:00 PM – 6 :00 PM
Plenary Talk
Gregory Voth, University of Chicago, USA, Chair

Robert Stroud, University of California, San Francisco, USA
The Conundrum of How and When Proton(s) Drive Transport?

6:00 PM – 7:30 PM
Dinner

Session I: Multiscale Aspects of Proton Transport
                    Emily Liman, University of Southern California, USA, Chair

7:30 PM – 8:00 PM
Jessica Swanson, University of Utah, USA
Multiscale Responsive Kinetic Modeling of Proton-Coupling in Ion Channels and Transporters

8:00 PM – 8:30 PM
Alexey Amunts, The Max Planck Institute of Molecular Physiology, Germany
Coupling of Bioenergetic Electron Transport with Proton Dynamics

8:30 PM – 10:00 PM
Get Together (Wine & Cheese)

Monday, August 4, 2025

7:30 AM - 8:30 AM
Breakfast

8:00 AM – 12:30 PM
Registration

Session II: Proton Transport in Mitochondria
                     Leonid Sazanov, Institute of Science and Technology, Austria, Chair

9:00 AM – 9:30 AM
Mario Vazdar, University of Chemistry and Technology in Prague, Czech Republic
Molecular Dynamics Simulations of Proton Transfer in Mitochondrial Uncoupling Proteins

9:30 AM – 10:00 AM
Elena E. Pohl, University of Veterinary Medicine Vienna, Austria
Understanding the Molecular Mechanism of Mitochondrial Uncoupling induced by 2,4-Dinitrophenol

10:00 AM – 10:30 AM
Vivek Sharma, University of Helsinki, Helsinki, Finland *
Thermodynamics and Kinetics of Proton Transfer Reactions Catalyzed by Respiratory Complex

10:30 AM – 10:45 AM
Md. Raihan Uddin, Department of Biochemistry, NY, USA *
Proton Pumping Mechanism of Photosynthetic NDH-1 and Complex I

10:45 AM – 11:15 AM
Coffee Break

Session III: Transporters
                       Peter Pohl, Johannes Kepler University Linz - JKU, Austria, Chair

11:15 AM – 11:45 AM
Simon Newstead, University of Oxford, United Kingdom
Understanding the Role of Protons in Drug Transport Via SLC15A2

11:45 AM – 12:00 PM
Zhi Yue, University of Chicago, USA*
Protons Enable Calcium Passage through the Hydrophobic Channel in the SARS-CoV-2 Envelope Protein

12:00 PM – 12:15 PM
Jonathan D Colburn, University of Oxford, United Kingdom *
From Sequence to Mechanism: Insights into Proton Coupling in Cystinosin from Multiscale Molecular Simulations

12:30 PM – 1:30 PM
Lunch

1:30 PM – 5:30 PM
Hiking/Interactions

5:30 PM – 6:30 PM
Dinner

Session IV: Light Driven Proton Transport
                       Satoshi Tsunoda, Nagoya Institute of Technology, Japan, Chair

6:30 PM – 7:00 PM
Peter Pohl, Johannes Kepler University Linz, Austria
Phototriggered Proton-Selective Carrier Currents

7:00 PM – 7:30 PM
Noam Agmon, The Hebrew University of Jerusalem, Israel *
Multi-Proton Dynamics Near Membrane-Water Interface

7:30 PM – 8:00 PM
Yoshitaka Kato, University of Tokyo, Japan *
Proton Transport Mechanism of Newly Discovered Light-Driven Inward Proton Pump, ELTxer

8:00 PM – 10:00 PM
Poster Session I (Wine & Cheese)

Tuesday, August 5, 2025

7:00 AM – 8:30 AM
Breakfast

8:00 AM – 12:30 PM
Registration/Information

Session V: Voltage-gated Proton Channels
                     Jessica Swanson, University of Utah, USA, Chair

9:00 AM – 9:30 AM
Thomas DeCoursey, Rush University Medical Center, USA
Dissecting the Signature Sequence of the Voltage-gated Proton Channel

9:30 AM – 10:00 AM
Boris Musset, Paracelsus Medical University, Austria
Somatic Cancer Mutations in the S4 Transmembrane Segment of the Human Voltage-Gated Proton Channel HV1

10:00 AM – 10:30 AM
Akira Kawanabe, Hiroshima University, Japan
The Functional Regulation of the Voltage-Gated Proton Channel by ATP

10:30 AM – 10:45 AM
Gustavo Chaves, Paracelsus Medical University, Nuremberg, Germany *
Exploring Biophysical Divergences within the Voltage-Gated Proton Channel (Hv) Family

10:45 AM – 11:15 AM
Coffee Break

Session VI: Proton Pump Rhodopsins
                       Rubin Liang, Texas Tech University, USA, Chair

11:15 AM – 11:45 AM
Satoshi Tsunoda, Nagoya Institute of Technology, Japan
Driving Force of Various Proton Pump Rhodopsins

11:45 AM – 12:15 PM
Keiichi Inoue, University of Tokyo, Japan
Proton Transfer in the Photocyclic Reaction of Ion-Transporting Microbial Rhodopsins

12:15 PM – 12:30 PM
Masaki Tsujimura, University of Tokyo, Japan and RIKEN Pioneering Research Institute, Wako, Japan *
Converting a Chloride-Pumping Rhodopsin into a Proton Pump

12:30 PM – 1:30 PM
Lunch

1:30 PM – 5:30 PM
Hiking/Interactions

5:30 PM – 6:30 PM
Dinner

Session VII: Proton Transport: Physiology and Disease
                         Simon Newstead, University of Oxford, United Kingdom, Chair

6:30 PM – 7:00 PM
Joseph Mindell, NINDS, NIH, USA
Mechanisms of Novel Diseases Disrupting Lysosomal Via ClC-7 Chloride Transporter Mutations

7:00 PM – 7:30 PM
Emily Liman, University of Southern California, USA
Targeting OTOP Proton Channels: Insights from Chemical Modulators

7:30 PM – 7:45 PM
Daniel R. Sauter, Sophion Bioscience Inc., San Diego, USA *
Automated Patch Clamp Assay for Proton-Activated HOTOP1 Channel

8:00 PM – 10:00 PM
Poster Session II (Wine & Cheese)

Wednesday, August 6, 2025

7:00 AM – 8:30 AM
Breakfast

8:00 AM – 12:30 PM
Registration/Information

Session VIII: Origins and Effects of Proton Transport in Proteins
                         Qiang Cui, Boston University, USA, Chair

9:00 AM – 9:30 AM
Gerhard Hummer, Max Planck Institute of Biophysics, Germany
Molecular Simulations of Proton-Coupled Machines

9:30 AM – 10:00 AM
Ana-Nicoleta Bondar, University of Bucharest, Romania
Water- And Lipid-Mediated Hydrogen-Bond Networks of pHD Peptide Pores

10:00 AM – 10:30 AM
Huong Kratochvil, University of North Carolina at Chapel Hill, USA
Modulating Proton Transport Through Designed Hydrogen-Bonding Networks

10:30 AM – 10:45 AM
Merissa Brousseau, University of Wisconsin-Madison, USA *
Beyond Peak Currents: Solid-Supported Membrane Electrophysiology as a Means of Investigating Universal Transport Model

10:45 AM – 11:15 AM
Coffee Break

Session IX: Effect of Lipid Membranes on Proton Transport
                       Noam Agmon, Hebrew University of Jerusalem, Israel, Chair

11:15 AM – 11:45 AM
Jochen Hub, Saarland University, Germany
How Complex Lipid Compositions Control Mechanical Stability of Biomembranes

11:45 AM – 12:00 PM
Ambili Ramanthrikkovil Variyam, Technion - Israel Institute of Technology, Israel *
Proton Diffusion on the Surface of Mixed Lipid Membranes Highlights the Role of Membrane Composition

12:00 PM – 12:15 PM
Shizhen Wang, University of Missouri-Kansas City, Kansas City, USA *
Regulation of Proton Transport by Membrane Sterols

12:30 PM – 1:30 PM
Lunch

1:30 PM – 5:30 PM
Hiking/Interactions

5:30 PM – 6:30 PM
Dinner

Session X: Proton Transport Mechanisms
                     Gerhard Hummer, Max Planck Institute of Biophysics, Germany, Chair

6:30 PM – 7:00 PM
Qiang Cui, Boston University, USA
Exploring the Mechanism of Ion Conduction Through Protein E of SARS-CoV-2

7:00 PM – 7:30 PM
Katharine White, University of Notre Dame, USA
Regulating Proteins, Pathways, and Cell Behaviors

7:30 PM – 8:00 PM
Rubin Liang, Texas Tech University, USA
Decrypting the Non-Adiabatic Photoinduced Electron Transfer Mechanism in Light-Sensing Cryptochrome

8:00 PM – 10:00 PM
Poster Session III (Wine & Cheese)

Thursday, August 7, 2025

7:00 AM – 8:30 AM
Breakfast

8:00 AM – 12:30 PM
Registration/Information

Session XI: Proton Transport Tied to Structure
                       Ana-Nicoleta Bondar, University of Bucharest, Romania, Chair

9:00 AM – 9:30 AM
Marylin Gunner, City College of New York, USA
Coupled protonation states and hydrogen bond networks in proton pumps

9:30 AM – 10:00 AM
Kota Katayama, Nagoya Institute of Technology, Japan
Structural Insights into Spectral Tuning from the Three-Dimensional Structures of Red and Green Cone Pigments

10:00 AM – 10:15 AM
Ruchika Bajaj, University of California, San Francisco *
Understanding ABC Transporters to Navigate Human Diseases

10:45 AM – 11:15 AM
Coffee Break

Session XII: Modelling of Charge Transport
                        Mario Vazdar, University of Chemistry and Technology in Prague, Czech Republic, Chair

11:15 AM – 11:45 AM
Gregory Voth, University of Chicago, USA
Advances in Modeling Transmembrane Proton Transport in Biomolecular Systems

11:45 AM – 12:00 PM
Jong Ho Choi, University of Chicago, USA
Water Connectivity and its Cooperative Coupling to Proton Transport in A Key Region Of Complex I

12:00 PM – 12:15 PM
Chang Yun Son, Seoul National University, South Korea *
Modeling Classical and Quantum Charge Transport in Large Scale with Stochastic Λ-Dynamics

12:15 PM – 1:30 PM
Lunch

1:30 PM – 6:00 PM
Hiking/Interactions

6:00 PM – 7:00 PM
Dinner

7:00 PM – 8:00 PM
Plenary Talk
Elena E. Pohl, University of Veterinary Medicine Vienna, Austria, Chair

Leonid Sazanov, Institute of Science and Technology Austria
The Mechanism of Proton Translocation by Respiratory Complex I

8:00 PM – 8:15 PM
Closing Remarks Biophysical Journal Poster Awards
Elena E. Pohl, University of Veterinary Medicine Vienna, Austria
Gregory Voth, University of Chicago, USA

8:15 PM – 10:00 PM
Open Discussion to all Topics & Executive Meeting (Wine & Cheese)

 

* Contributed talks selected from among submitted abstracts