Sunday, June 2, 2024

4:00 PM - 6:00 PM

6:00 PM - 7:00 PM

7:00 PM - 7:10 PM
Opening Remarks
Linda Columbus, University of Virginia and Syma Khalid, University of Oxford, United Kingdom, Conference Organizers

7:10 PM - 8:10 PM
Keynote Address
Barbara Baird, Cornell University, USA
How Does the Plasma Membrane Participate in Stimulated Cell Signaling?

8:15 PM - 9:15 PM

Monday, June 3, 2024

7:00 AM - 8:30 AM

Session I: Membrane Interactions and Interfaces
Syma Khalid, University of Oxford, United Kingdom, Chair

9:00 AM - 9:30 AM
Alison Rodger, Macquarie University, Australia
Unravelling Molecular Complexity: Small Steps with Polarised Light to Try to See How Biomolecules Work Together

9:35 AM – 9:50 AM
Douglas Eaton, Emory University Medical School, USA *
Electrostatic Interactions of ENaC, MLP-1, and PIP2

9:55 AM - 10:10 AM
Timothy Carpenter, Lawrence Livermore National Laboratory, USA *
An Anisotropic Continuum Model That Captures Molecular-Level Protein-Membrane Interactions

10:15 AM - 10:35 AM
Coffee Break and Group Photo

10:35 AM - 11:05 AM
Peter Tieleman, University of Calgary, Canada
Lipid-Protein Interactions and Possible Roles in Membrane Structure

11:10 AM - 11:40 AM
Brian Fuglestad, Virginia Commonwealth University, USA
Enhanced Tools and Strategies for Exploration of Structure, Function, and Inhibition at Protein-Membrane Interfaces

11:45 AM - 12:10 PM
Flash Talks I

12:10 PM - 1:00 PM

1:00 PM - 4:00 PM
Free Time

4:00 PM - 6:00 PM
Poster Session I

6:00 PM - 7:00 PM

Session II: Bacterial Membranes and Membrane Proteins
Shalini Low-Nam, Purdue University, USA, Chair

7:00 PM – 7:30 PM
Markus Weingarth, Utrecht University, The Netherlands
The Mechanisms of Lipid-Targeting Antibiotics

7:35 PM - 8:05 PM
Syma Khalid, University of Oxford, United Kingdom
Computational Microbiology of the E. coli Outer Membrane: A New Picture Is Emerging

8:10 PM – 8:40 PM
George Ongwae, University of Virginia, USA
Measurement of Accumulation of Molecules in Diderm Bacteria, and in Phagocytosed S. aureus Cells in Macrophages

8:45 PM – 9:15 PM
Fillipo Mancia, Columbia University Medical Center, USA
Structural Basis of Lipopolysaccharide Biosynthesis and Modification

9:20 PM – 9:35 PM
Timothée Rivel, Masaryk University, Czech Republic *
Simulating Polymyxin-Induced Divalent Ions Displacement in the Outer Membrane of Gram-Negative Bacteria

Tuesday, June 4, 2024

7:00 AM - 8:30 AM

Session III: Viral and Phage Membranes and Membrane Proteins
Alison Rodger, Macquarie University, Australia, Chair

9:00 AM - 9:30 AM
Mei Hong, MIT, USA
Structure and Dynamics of Membrane-Bound Virus Ion Channels from Solid-State NMR

9:35 AM – 9:50 AM
Jinwoo Lee, University of Maryland, USA *
Exploring the Vital Role of the Anionic Lipid in Initiating SARS-CoV-2 Fusion

9:55 AM - 10:10 AM
Elka Georgieva, Texas Tech University, USA *
Viral Protein-Lipid Interactions Illustrated by the Influenza a M2 and Hepatitis C Virus Core Proteins

10:15 AM - 10:30 AM
Susan Fetics, Duke Human Vaccine Institute, USA *
Membrane Technologies for Structural Determination of Virus Entry and Transmission

10:35 AM - 11:05 AM
Coffee Break

11:05 AM - 11:35 AM
Bil Clemons, California Institute of Technology, USA
Mechanisms of Phage Derived Antibiotics

11:40 AM – 11:55 PM
Huong Kratochvil, University of North Carolina at Chapel Hill, USA *
Distilling Complex Proton Channels into Simple Model Systems Through Protein Design

12:00 PM - 1:00 PM

1:00 PM - 4:00 PM
Free Time

4:00 PM - 6:00 PM
Poster Session II

6:00 PM - 7:00 PM

Session IV: Membrane Structure and Properties
Sarah Rouse, Imperial College London, United Kingdom, Chair

7:00 PM – 7:30 PM
Maria Makarova, University of Birmingham, United Kingdom
Lipid Resilience: Unveiling Membrane Rescue in Oxygen-Deprived Environments

7:35 PM - 8:05 PM
Linda Columbus, University of Virginia, USA
Structure, Organization, Packing, and Dynamics of Bicelles

8:10 PM – 8:25 PM
Jeriann Beiter, University of Chicago, USA *
Beyond Bar Domains: Understanding Membrane Remodeling Through Molecular Simulation

8:30 PM – 8:45 PM
Stefanie Schmieder, Boston Children's Hospital, Harvard Medical School, USA *
Synthesis of a GM1 Structural Library Reveals Distinct Membrane Behavior Based on Ceramide Structure

8:50 PM – 9:05 PM
Shefin Sam George, Stanford University, USA *
TMC Proteins Regulate Cochlear Hair Bundle Membrane Viscosity Through Lipid Scramblase Activity

9:10 PM – 9:25 PM
Mark Arcario, Washington University in Saint Louis, USA *
Flexibility of Larger Nanodiscs Allows for More Native-Like Physical Properties of Incorporated Lipids

9:30 PM - 10:30 PM

Wednesday, June 5, 2024

7:00 AM - 8:30 AM

Session V: Membrane Protein Folding
Itay Budin, University of California, San Diego, USA, Chair

9:00 AM - 9:30 AM
Heedeok Hong, Michigan State University, USA
Membrane Protein Folding-What Lipids Do

9:35 AM - 10:05 AM
Nir Fluman, Weizmann Institute of Science, Israel
Membrane Protein Sequence Features That Optimize Their Insertion and Folding

10:10 AM - 10:25 AM
Katherine Clowes, Vanderbilt University, USA *
A High-Throughput Screen to Identify Modifiers of KCNQ1 Trafficking

10:30 AM - 10:45 AM
Libin Ye, University of South Florida, USA *
19F-qNMR-Assisted Structural Elucidation of a Ligand-Free GPCR-G Protein Intermediate Complex

10:50 AM – 11:10 AM
Coffee Break

11:10 AM - 11:25 AM
Hao Yu, Huazhong University of Science and Technology, China *
Molecular Determinants of Membrane Protein Folding and Assembly Revealed By AFM-Based Force Spectroscopy

11:30 AM – 11:45 AM
Kelly Risch, Texas A&M University, USA *
The Role of Conformational Entropy in Integral Membrane Protein Biophysics

11:50 AM – 12:15 PM
Flash Talks II

12:15 PM - 1:00 PM

1:00 PM - 4:00 PM
Free Time

4:00 PM - 6:00 PM
Poster Session III

6:00 PM - 7:00 PM

Session VI: Membrane Protein Structure and Dynamics
Sarah Shelby, University of Tennessee, Knoxville, USA, Chair

7:00 PM - 7:30 PM
Janice Robertson, Washington University in St. Louis, USA
A Molecular Model for Ion Channel and Transporter Dimerization in Membranes

7:35 PM - 8:05 PM
Sarah Rouse, Imperial College London, United Kingdom - CCPBioSim Sponsored Speaker
Modulation of Class B1 GPCRs by the Plasma Membrane Environment

8:10 PM – 8:40 PM
Alemayehu Gorfe, University of Texas Medical School Houston, USA
Membrane Interactions and Inhibition of RAS Proteins

8:45 PM - 9:00 PM
Jane Allison, University of Auckland, New Zealand *
PI3Ka Membrane Binding Is Associated with Altered Membrane Properties

9:05 PM – 9:20 PM
Caroline Brown, Yale University, USA *
A High-Throughput Proteome-Wide Platform for Capturing Membrane Proteins in Their Native Environment for Structural and Functional Studies

9:25 PM – 9:40 PM
Timothée Chauviré, Cornell University, USA *
An Approach to Study Flavoproteins by in Cell Electron Spin Resonance (ESR) Spectroscopy: The Membrane Protein Aerotaxis Transducer AER

Thursday, June 6, 2024

7:00 AM - 8:30 AM

Session VII: Membrane Organization and Signaling
Heedeok Hong, Michigan State University, USA, Chair

9:00 AM - 9:30 AM
Shalini Low-Nam, Purdue University, USA
Shaping of CAR T Cell Activation by the Membrane Reaction Landscape

9:35 AM – 9:50 AM
Katherine Stefanski, Vanderbilt University, USA *
Small-Molecule Modulators of Protein Lipid Raft Affinity and Lipid Raft Stability

9:55 AM - 10:10 AM
Nirmalya Bag, Indian Institute of Technology Kharagpur, India *
Boxcar Imaging Fluorescence Correlation Spectroscopy Reveals Kinetics of Raft Stabilization in Antigen-Activated Mast Cells

10:15 AM - 10:30 AM
Silas Boye Nissen, Stanford University, USA *
The Molecular Mechanism of the Core Planar Cell Polarity Complex Elucidated with Single-Molecule Imaging Techniques in Live Drosophila Wing Cells

10:35 AM – 10:55 AM
Coffee Break

10:55 AM - 11:25 AM
Wade Zeno, University of Southern California, USA
Functional Disorder at Biological Membranes

11:30 AM - 12:00 PM
Sarah Shelby, University of Tennessee, Knoxville, USA
Immune Receptor Signaling Domains Arise from a Responsive Plasma Membrane

12:05 PM - 1:00 PM

1:00 PM - 4:00 PM
Free Time

4:00 PM - 6:00 PM
Poster Session IV

6:00 PM - 7:00 PM
Closing Remarks and Biophysical Journal Poster Awards

Session VIII: Cholesterol, Lipids, and Phases
Wade Zeno, University of Southern California, USA, Chair

7:00 PM - 7:30 PM
Itay Budin, University of California, San Diego, USA
The Biophysical Tight Rope of Cell Membranes: Surprising Lessons Learned From Extreme Lipidome Adaptation in the Deep Ocean

7:35 PM - 8:05 PM
Kandice Levental, University of Virginia, USA
Asymmetric Distribution of Phospholipids and Cholesterol Results in Unique Plasma Membrane Properties

8:10 PM - 8:40 PM
Francisco Barrera, The University of Tennessee Knoxville, USA
Cholesterol Controls the Assembly and Activity of the EphA2 Receptor

8:45 PM – 9:00 PM
Niek van Hilten, University of California, San Francisco, USA *
Systematic Computational Analysis of Lipid Scrambling by TMEM16 Family Members

9:05 PM – 9:20 PM
Malavika Varma, Carnegie Mellon University, USA *
Expanding Coarse-Grained Model for Lipids to Investigate Lo/Ld Phase Coexistence

9:25 PM - 9:40 PM
Jason Hafner, Rice University, USA *
Steroid Ring Vibrations Elucidate Cholesterol's Influence on Lipid Membranes

Friday, June 7, 2024

7:00 AM - 8:30 AM
Breakfast and Departure

* Short Talks selected from among submitted abstracts