Subgroup Saturday

Subgroup Co-Chairs:  Sonia Cortassa, NIH, USA and Elena Dedkova, University of California, Davis, USA

Symposium Chair:  Ambre Bertholet, University of California, Los Angeles, USA   

Symposium Topic:  Unexpected Regulators of the Mitochondrial Respiratory Chain

Symposium Time:  8:30 AM - 12:30 PM PST   

Symposium Room:  7AB

Business Meeting:  12:00 Noon - 12:30 PM PST

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Speakers:

8:35 AM Martin Picard, Columbia University, USA
Neuroendocrine and Psychobiological Regulators of the Mitochondrial Respiratory Chain

9:05 AM Elena Dedkova, University of California, Davis, USA
Lethal Cardiomyopathy in Freidreich's Ataxia: Is There a Hope?

10:10 AM Dipayan Chaudhuri, University of Utah, USA
The Mitochondrial Calcium Uniporter Preserves Energetic Homeostasis during Complex I Dysfunction

10:40 AM Antonio Martinez-Ruiz, Universidad Complutense de Madrid, Spain
Sodium Regulation of Inner Membrane Fluidity as an Unexpected Regulator of the Mitochondrial Respiratory Chain

11:20 AM Isha Jain, University of California, San Francisco, USA
Turning the Oxygen and Vitamin Dials

 

Subgroup Chair: Ravi Radhakrishnan, University of Pennsylvania, USA

Symposium Time:  1:30 PM - 5:30 PM PST    

Symposium Room:  6D

Business Meeting:  5:00 - 5:30 PM PST

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Speakers:

1:35 PM Ariel Furst, Massachusetts Institute of Technology, USA
Engineering Electroactive Microbes for Environmental Sensing 

 

2:05 PM Kalpana Mandal, Terasaki Institute for Biomedical Innovation, USA
Oxygen-generating microparticles increase cardiac contractility, downregulate HIF-1α expression, and mitigate ischemic injury

 

2:35 PM Ryan Odstrcil, Washington State University, USA
Predicting Reaction Pathways and Accelerating Protein Conformation Sampling with Machine Learning

 

3:15 PM Chang Liu, University of South Carolina, USA
A Click Chemistry Amplified Nanopore (CAN) Assay for Ultrasensitive Quantification of HIV p24 Antigen in Clinical Samples 

 

3:45 PM Aaron Streets, University of California, Berkeley, USA
Multi-parameter Epigenetic Profiling of Single Cells and Single Molecules 

 

4:15 PM Padmini Rangamani, University of California, San Diego, USA
Modeling Approaches to Synaptic Plasticity

Subgroup Chair: Sua Myong, Johns Hopkins University, USA

Symposium Time: 8:30 AM - 12:30 PM PST  

Symposium Room: 11AB

Business Meeting:  10:15 AM - 10:40 AM PST

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Speakers:

8:35 AM Gabriela Schlau-Cohen, Massachusetts Institute of Technology, USA
Following Transmembrane Conformational Signaling with Single-molecule FRET 

 

9:00 AM Scott Blanchard, St. Jude Children's Research Hospital, USA
Single-molecule Perspectives on mRNA Decoding Fidelity in Bacteria and Human 

 

9:25 AM Maria Garcia-Parajo, ICFO Institute of Photonic Science, Spain
Dynamic Mapping of Individual Molecules and their Compartments by High-density Single Particle Tracking 

 

9:50 AM Hagen Hofmann, Weizmann Institute of Science, Israel
Diffusion of a Disordered Protein on Its Folded Ligand 

 

10:40 AM Chunte Sam Peng, Massachusetts Institute of Technology, USA
Ultralong-term, Real-time Tracking of Single Cargoes in Living Neurons

 

11:05 AM Selected Rapid Fire Talks: Erik Dylan Holmstrom, Olivier Duss, Gopika Gopan, Dohyun Kim, and Steven Dylan Emil Fried

 

11:25 AM Young Fluorescence Investigator Award & Talk: Leonel Malacrida

 

11:55 AM Gregorio Weber Award & Lecture

 

Subgroup Chair: Huan Xiang-Zhou, University of Illinois Chicago, USA

Program Co-Chairs: Kimberly Reynolds, University of Texas Southwestern, USA and Paul Whitford, Northeastern University, USA

Symposium Time: 8:30 AM - 12:30 PM PST    

Symposium Room: 6E

Business Meeting:  12:00 Noon - 12:30 PM PST

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Speakers:

8:35 AM Flash Talks: Andrea Ghisleni, Andrew Savinov, and Digvijay Singh

 

9:15 AM Margaret Cheung, Pacific Northwest National Laboratory, USA
Emergent Protein Assemblies in a Cell 

 

9:35 AM Alex Guseman, University of Pittsburgh, USA
Peering Into the Crystallin Ball of the Eye Lens 

 

9:55 AM Milo Lin, University of Texas, Southwestern Medical Center, USA
Predicting the Transition States of Protein Aggregation 

 

10:30 AM Sarah Keane, University of Michigan, USA
Structural Determinants of MicroRNA Biogenesis 

 

10:50 AM Thibault Mayor, University of British Columbia, Canada
Looking in the Garbage to Get Clues on Aging and Protein Folding 

 

11:10 AM Alison Sweeney, Yale University, USA
Reflectin Proteins as Biopolymers In Vivo

Subgroup Chair: Jorge E. Contreras, University of California, Davis, USA

Symposium Time: 8:30 AM - 12:30 PM PST     

Symposium Room: 6B

Business Meeting:  10:35 - 11:00 AM PST

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Speakers:

8:35 AM Elena Lehmann, University of Zurich, Switzerland
Heteromeric LRRC8 Channel Assemblies and Their Impact on Channel Activity 

 

9:05 AM Johanna Syrjanen, Cold Spring Harbor Laboratory, USA
A Tale of Two Pores 

 

9:35 AM Yu-Hsin Chiu, National Tsing Hua University, Taiwan
Pharmacology and Activation Mechanisms for Large-pore Pannexin 1 Channels: From a Single-channel Perspective 

 

10:05 AM Donglin Bai, Western University (Ontario), Canada
Hydrophobic and Hydrophilic Residues in Amino Terminal Domain of Cx46 and Cx50 Are Critical for their Gap Junction Channel Gating and the Rate of Ion Permeation 

 

11:00 AM Yun Lyna Luo, Western University (California), USA
Computational Studies of Molecular Permeation through Large-pore Channels 

 

11:30 AM Pablo Gaete, University of California, Davis, USA
Novel Biophysical Properties in Large-pore Channels 

 

12:00 PM J. Kevin Foskett, University of Pennsylvania Medicine, USA
Molecular Physiology of CALHM Ion Channels

Subgroup Chair: Ariane Briegel, Leiden University, Netherlands

Program Co-Chairs: Henriette Autzen, University of Copenhagen, Denmark, Gabriel Lander, Scripps Research Institute, USA, Cristina Santarossa, NYU Langone Health, USA, Rosemary Cater, Columbia University, USA, and Meghna Gupta, University of California, San Francisco, USA

Symposium Time: 8:30 AM - 12:30 PM PST

Symposium Room: 6F

Business Meeting:  12:15 - 12:30 PM PST

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Speakers:

8:35 AM Oliver Clarke, Columbia University, USA
Architecture of Erythrocyte Ankyrin-1 Complexes 

 

9:00 AM Ellen Zhong, Massachusetts Institute of Technology and Princeton University, USA
Machine Learning for Cryo-EM Reconstruction 

 

9:25 AM Rebecca Thompson, University of Leeds, United Kingdom
How “Native” is Your Protein? Impacts of Cryo-EM Sample Preparation on Protein Structure 

 

9:50 AM Melody Campbell, Fred Hutchinson Cancer Research Center, USA
Untangling Integrin Dynamics Using Cryo-EM 

 

10:00 AM Debnath Ghosal, University of Melbourne, Australia
Understanding Architecture, Assembly, and Regulation of Bacterial Toxin Delivery Systems by Electron Cryotomography 

 

10:30 AM Panel Discussion on Map Quality: Single Particle Cryo-EM Validation - What to Submit with your Manuscript

 

10:40 AM Abhay Kotecha, Thermo Fisher Scientific, Netherlands
Towards High-Resolution and High-Throughput Structural Biology with Cryo-EM 

 

10:55 AM Elizabeth Villa, University of California, San Diego, USA
Molecular Architecture of the Jumbo Bacteriophage Nuclear Shell 

 

11:20 AM Yi-Wei Chang, University of Pennsylvania Medicine, USA
Rhoptry Secretion System Structures and Regulatory Mechanisms in Apicomplexan Parasites Revealed Using Cryo-ET

Subgroup Chair: Jeanne Stachowiak, University of Texas - Austin, USA

Program Co-Chairs: Samrat Mukhopadhyay, Indian Institute of Science Education and Research, India, and Sapun Parekh, University of Texas - Austin, USA and Max Planck Institute for Polymer Research, Germany

Symposium Time: 1:30 PM - 5:30 PM PST 

Symposium Room: 6C

Business Meeting:  5:10 - 5:30 PM PST

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Speakers:

1:35 PM Keynote Speaker: Jane Dyson, Scripps Research Institute, USA
Functional Disorder in p53 

 

2:10 PM Elizabeth Komives, University of California, San Diego, USA
The Many Functions of Intrinsic Disorder in NF-κ B Signaling 

 

2:35 PM Anita Donlic, Princeton University, USA
Linking Molecular-Level RNA-Protein Interactions with Mesoscale Properties of the Nucleolus

 

2:50 PM Priya Banerjee, University at Buffalo, USA
Shedding Light on the Phase Separation Landscape of Intrinsically Disordered Proteins 

 

3:20 PM Lucia Chemes, Universidad Nacional de San Martin, Argentina
Conformational Buffering as a Mechanism Underlying Dimensional Compensation and Functional Evolution in Intrinsically Disordered Proteins 

 

3:45 PM Yohan Lee, University of Texas - Austin, USA
Compression of Lipids Drives Transbilayer Coupling of Protein Condensates

 

4:00 PM Paolo Arosio, ETH Zurich, Switzerland
Acceleration and Inhibition of Amyloid Formation by Biomolecular Condensates 

 

4:25 PM Raymond Berkeley, University of California, San Diego, USA
Structural Investigations of the Small Heat Shock Protein Hspb1 in the Presence of a Phase-Separated Client

 

4:40 PM Monika Fuxreiter, University of Padova, Italy
The Fundamental Nature of the Droplet State of Proteins

Subgroup Chair: Arne Gennerich, Albert Einstein College of Medicine, USA

Symposium Time: 1:30 PM - 5:30 PM PST    

Symposium Room: 5AB

Business Meeting:  5:20 - 5:30 PM PST

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Speakers: 

1:35 PM Shixin Liu, Rockefeller University, USA
Machines on Genes: A Single-Molecule Perspective 

 

2:00 PM Ibrahim Cissé, Max Planck Institute of Immunology & Epigenetics, Germany
Super-Resolution Imaging of Transcription in Live Mammalian Cells 

 

2:25 PM George Ghanim, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
Structural Basis of Human Telomerase Recruitment and Activation by Shelterin Proteins TPP1:POT1 

 

2:45 PM Jeff Mindrebo, Scripps Research Institute, USA
Substrate-Mediated Activation Mechanism of Human LONP1 

 

3:20 PM Xinglei Liu, Albert Einstein College of Medicine, USA
The Regulatory Function of the AAA4 ATPase Domain of Cytoplasmic Dynein 

 

3:40 PM Colleen Kelly, University of Vermont, USA
Thick Filament Dynamics: A Mechanism for Protein Replacement Within the Sarcomere 

 

4:00 PM Katarzyna Tych, University of Groningen, Netherlands
Single-Molecule Characterization of an Osmoregulatory Transporter 

 

4:25 PM Albert Weixlbaumer, Institute of Genetics and Molecular and Cellular Biology, National Centre for Scientific Research, France
Supramolecular Complexes Involved in the Coordination of Transcription and Translation

 

4:50 PM Flash Talk: K. Maria Mills, University of Missouri, USA
Human XPD is an Active Helicase with Low Processivity and Overall Unwinding Rate

 

5:00 PM Flash Talk: Jasmin Zarb, Johns Hopkins University, USA
Single-Molecule Studies Reveal that MutS'S Binding Characteristics are Mismatch Type and Context Dependent and Correlate with Mismatch Repair Efficiency in vivo

Subgroup Chair: Virgile Viasnoff, Mechanobiology Institute, National University of Singapore and CNRS, France       

Symposium Time: 1:30 PM - 5:30 PM PST 

Symposium Room: 6E

Business Meeting:  3:25 - 3:40 PM PST

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Speakers:

1:35 PM Pierre Nassoy, National Centre for Scientific Research, France
Cellular Self-assembly and Mechanosensing in Organoids and Tumor Models Encapsulated in Hydrogel Shells 

 

2:00 PM Tamal Das, Tata Institute of Fundamental Research, India
Emergent Features of Collective Cell Dynamics: A Mechanobiological Perspective 

 

2:35 PM Edwin Munro, University of Chicago, USA
Dynamics of a Self-pulled Epithelial Zipper 

 

3:00 PM Min Wu, Yale School of Medicine, USA
Coupled Oscillators in a Contractility-Generating Signal Transduction Network 

 

3:40 PM Award Talk: Alba Diz-Munoz, EMBL Heidelberg, Germany
More than the Sum: How Does a Composite Interface Govern Function?

 

4:05 PM Yee Han Tee, National University of Singapore
Actin Polymerization and Crosslinking Drive Left-Right Asymmetry in Single Cell and Cell Collectives 

 

4:15 PM Charles Cox, Victor Chang Research Institute, Australia 
Cardiac Piezo Channels in Health and Disease 

 

4:40 PM Arthur Beyder, Mayo Clinic, USA
Mechanogated Ion Channel Piezo2 Role in Gut Tactile Sensitivity 

 

5:05 PM Valeria Vasquez, University of Tennessee, USA
Dietary Fatty Acids Fine-Tune Neuronal and Non-Neuronal Cells’ Mechanical Response

Subgroup Chair:  Phyllis Hanson, University of Michigan, USA

Symposium Time: 8:30 AM - 12:30 PM PST     

Symposium Room: 6D

Business Meeting:  12:15 - 12:30 PM PST

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Speakers:

8:30 AM Felix Campelo, ICFO Institute of Photonic Science, Spain
The Biophysics of Bulky Cargo Export from the Endoplasmic Reticulum 

 

9:00 AM Emanuele Cocucci, Ohio State University, USA
Using Quantitative Microscopy Approaches to Study the Formation of Clathrin-Coated Vesicles 

 

9:30 AM Jayanta Debnath, University of California, San Francisco, USA
Emerging Roles for Secretory Autophagy in EV Biogenesis and Cargo Specification 

 

10:30 AM Susan Ferro-Novick, University of California, San Diego, USA
A Non-Canonical Role for a COPII Subunit in the Selective Degradation of the ER 

 

11:00 AM Wade Zeno, University of Southern California, USA
Interactions between Intrinsically Disordered Protein Regions and Curved Membrane Surfaces 

 

11:30 AM Jose Rizo-Rey, University of Texas Southwestern Medical Center, USA
Sir Bernard Katz Award Recipient: Molecular Mechanisms Underlying Calcium-Triggered Neurotransmitter Release

Subgroup Chair: Ingela Parmryd, University of Gothenburg, Sweden 

Symposium Time: 1:30 PM - 5:30 PM PST       

Symposium Room: 6B

Business Meeting:  5:20 - 5:30 PM PST

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Speakers:

1:35 PM Peter Tieleman, University of Calgary, Canada
Insights into Lipid-Protein Interactions from Computer Simulations 

 

2:00 PM Feng-Ching Tsai, Curie Institute, France
Mechanisms of Curved Membrane Protein IRSp53 Mediated Initiation and Stabilization of Cellular Protrusions 

 

2:25 PM Frances Separovic, University of Melbourne, Australia
Locating Antimicrobial Peptides in Model Membranes and Bacteria Using Solid-State NMR 

 

2:50 PM Marc Pilon, University of Gothenburg, Sweden
AdipoR2 Promotes Fatty Acid Desaturation, Elongation and Incorporation into Phospholipids in Response to Membrane Rigidification 

 

3:30 PM Jeffery Klauda, University of Maryland, USA
Modelling Natural Cell Membranes and How Lipid Asymmetry Influences Structure 

 

3:55 PM Thais Enoki, Cornell University, USA
Insights on Plasma Membrane Asymmetry from Studies of Asymmetric Model Membranes 

 

4:20 PM Toshihide Kobayashi, University of Strasbourg, France
Imaging Cholesterol Depletion at the Plasma Membrane by Methyl-Beta-Cyclodextrin Suggests Preferential Cholesterol Removal from the Inner Leaflet

 

4:45 PM Thomas E. Thompson Award Recipient: Rumiana Dimova, Max Planck Institute of Colloids and Interfaces, Germany

Subgroup Chair:  Indra Schroeder, University of Jena, Germany

Symposium Time: 1:30 PM - 5:30 PM PST     

Symposium Room: 6F

Business Meeting:  5:20 - 5:30 PM PST

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Speakers:

1:35 PM William Zagotta, University of Washington, USA
Conformational Dynamics: Channels and Beyond 

 

2:05 PM Lea Rems, University of Ljubljana, Slovenia
The Molecular Basis of Electroporation of Excitable Cells 

 

2:35 PM Ezry Santiago-McRae, Rutgers University, USA
Absolute Binding Affinities of Phospholipids to Erwinialigand-gated Ion Channel (elic) by Streamlined Alchemical Free Energy Perturbations (SAFEP)

 

3:10 PM Jana Shen, University of Maryland, USA
Mechanism of the Sodium-Proton Antiporters NhaA and NapA 

 

3:40 PM Tugba Ozturk, Lawrence Livermore National Laboratory, USA
The Role of the Membrane in Driving clc-ec1 Dimerization

 

4:00 PM Nicolas Wright, Duke University, USA
Cryo-EM Structure Determination of the Human Reduced Folate Carrier slc19a1 in Complex with Methotrexate

 

4:20 PM Oliver Einsle, University of Freiburg, Germany
An ABC Complex in the Metal Site Assembly of Nitrous Oxide Reductase 

 

4:50 PM Filippo Mancia, Columbia University, USA
The Molecular Mechanisms Underlying Cellular Uptake of Vitamin A

Subgroup Co-Chairs:  Ken'ya Furuta, National Institute of Information and Communication Technology, Japan, and Marija Zanic, Vanderbilt University, USA

Symposium Time: 1:30 PM - 5:30 PM PST      

Symposium Room: 6A

Business Meeting:  1:30 - 1:40 PM PST

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Speakers:

1:40 PM Erwin Peterman, Vrije University, The Netherlands
A Single-Molecule View on Intraflagellar Transport in C. elegans Chemosensory Cilia 

 

2:00 PM Christina Hueschen, Stanford University, USA
Actin Self-Organization in Gliding Parasitic Cells 

 

2:20 PM Wonmuk Hwang, Texas A&M University, USA
Position-Dependent Behavior of an Unbound Kinesin Head near the Microtubule Surface 

 

2:40 PM Naomi Courtemanche, University of Minnesota, USA
Balancing Act: Profilin's Competing Roles in Formin-Mediated Actin Polymerization 

 

3:00 PM Mitsuhiro Iwaki, National Institute of Information and Communications Technology, Japan
Dynamic Coordination of the Lever-Arm Swing of Myosin II in DNA Origami-Based Thick Filament 

 

3:30 PM Flash Talks from: Arianna Fornili, Irene Pertici, Madhura Duttagupta, Ana Duarte, and Yuan Gao

 

3:50 PM Emmanuel Derivery, MRC Laboratory of Molecular Biology, United Kingdom
Synthetic Reconstitution of Cortical Polarity to Study Cytoskeleton Symmetry Breaking 

 

4:10 PM Morgan DeSantis, University of Michigan, USA
Regulation of Cytoplasmic Dynein-1 during Cell Migration 

 

4:30 PM Shiladitya Banerjee, Carnegie Mellon University, USA
Origin of Pulsed Actomyosin Contractions and their Role in Cell Shape Control 

 

4:50 PM Claire Friel, University of Nottingham, United Kingdom
Ultra-rapid microtubule depolymerisation by the common ancestor of the Kinesin-13 family

 

5:10 PM Early Career Awardee: Scott Forth, Rensselaer Polytechnic Institute, USA
Deciphering the Mechanics of Microtubule Bundles in Mitosis

Subgroup Co-Chairs: Yamini Dalal, NIH, USA, and Anna Panchenko, Queen's University, Canada

Program Co-Chairs: Alexei Onufriev, Virginia Tech, USA, and Bin Zhang, Massachusetts Institute of Technology, USA

Symposium Time: 1:30 PM - 5:30 PM PST      

Symposium Room: 7AB

Business Meeting:  5:20 - 5:30 PM PST

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Speakers:

1:35 PM Job Dekker, University of Massachusetts, USA
Folding Chromosomes without Knotting Them 

 

2:05 PM Frank Alber, University of California, Los Angeles, USA
Characterizing the Variability and Organizing Principles of Whole Genome Structures by Multi-Modal Data Integration 

 

2:30 PM Yaojun Zhang, Johns Hopkins University, USA
Mechanical Frustration of Phase Separation in the Cell Nucleus by Chromatin 

 

2:55 PM Ranya Virk, Northwestern University, USA
Predicting Chemoevasion Potential of Cancer Cells from Statistical Chromatin Packing Behavior 

 

3:10 PM Best Poster Award Ceremony

 

3:30 PM Igor Sharakhov, Virginia Tech, USA
The 3D Genome Architecture in Human Malaria Vectors 

 

3:55 PM Mario Nicodemi, University of Naples, Italy
Phase Transitions in the Nucleus of Cells Shape Chromatin Folding 

 

4:20 PM Shasha Chong, California Institute of Technology, USA
Transcriptional Control by Low-Complexity Domain Interactions: A Single-Molecule Perspective 

 

4:45 PM Devarajan (Dave) Thirumalai, University of Texas Austin, USA
Changing Structures of Chromosomes During a Cell Cycle: Role of Multiple Motors

Subgroup Chair: Chan Cao, Ecole Polytechnique Federale de Lausanne, Switzerland

Symposium Time: 8:30 AM - 12:30 PM PST      

Symposium Room: 5AB

Business Meeting:  12:20 - 12:30 PM PST

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Speakers:

8:35 AM Cynthia Burrows, University of Utah, USA
Nanopore Sequencing of Nucleic Acids from Cells under Stress 

 

9:00 AM Reuven Gordon, University of Victoria, Canada
Rapid Single Protein Analysis by Nanoaperture Optical Tweezers 

 

9:25 AM Simon Scheuring, Cornell University, USA
High-Speed Atomic Force Microscopy for Dynamic Single Molecule Structural Biology 

 

10:30 AM Philip Tinnefeld, Ludwig Maximillians University Munich, Germany
Enhancement Mechanisms for Single-molecule Sensing and Superresolution with DNA Nanotech 

 

10:55 AM Fang Huang, Purdue University, USA
Ultra-High Resolution Structural and Molecular Imaging of Whole Cells and Tissues

 

11:20 AM Stefan Howorka, University College London, United Kingdom
Probing and Piercing Lipid Bilayers with DNA Nanostructures

Subgroup Chair:  Ulrike Endesfelder, Bonn University, Germany

Program Chair:  Pallav Kosuri, Salk Institute for Biological Studies, USA

Symposium Time: 8:30 AM - 12:30 PM PST       

Symposium Room: 6C

Business Meeting:  12:05 - 12:30 PM PST

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Speakers:

8:40 AM Hawa Racine Thiam, Stanford University, USA
Cellular Biophysics of NETosis: From Membrane Remodeling to Extracellular DNA Release

 

9:10 AM James Friend, University of California, San Diego, USA
The Mechanics of Sonogenetics

 

10:30 AM Khalid Salaita, Emory University, USA
Caught Red-Handed: DNA Probes to Measure Cellular Traction Forces 

 

11:30 AM Srigokul Upadhyayula, University of California, Berkeley, USA
Making the Invisible Visible: Imaging Subcellular Dynamics in Multicellular Systems

Subgroup Co-Chairs:  Zev Bryant, Stanford University, USA and Wesley Wong, Harvard University, USA

Symposium Time: 1:30 PM - 5:30 PM PST      

Symposium Room: 11AB

Business Meeting:  3:30 - 4:15 PM PST

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Speakers:

1:30 PM Ruben Gonzalez, Jr., Columbia University, USA
Realtime Observation of Substrate Translocation Dynamics in an ABC Transporter 

 

1:52 PM Sabrina Leslie, University of British Columbia, Canada
Tether-Free, Single-Molecule Microscopy of DNA Interactions in Out-of-Equilibrium Conditions 

 

2:14 PM Jie Yan, National University of Singapore, Singapore
The Mechanical Activation of Talin- and Vinculin-Mediated Rigidity Sensing of Extracellular Matrix 

 

2:36 PM Wendy Thomas, University of Washington, USA
How Some Single Receptor-Ligand Bonds Lock Instantly into a Long-Lived Force-Resistant State 

 

2:58 PM Pallav Kosuri, Salk Institute, USA
Origami Movement Microscopy 

 

3:30 PM Subgroup Business Meeting and Late-Breaking Science

 

4:14 PM Olga Dudko, University of California, San Diego, USA
Universality vs. Specificity in Synaptic Transmission 

 

4:36 PM Felix Ritort, University of Barcelona, Spain
RNA Cold Misfolding 

 

4:58 PM Eugene Kim, Max Planck Institute, Frankfurt, Germany
DNA Loop Extrusion Is a Conserved Mechanism among All Eukaryotic SMC Complexes

 

Subgroup Chair: Gregory A. Voth, University of Chicago, USA

Symposium Time: 8:30 AM - 12:30 PM PST    

Symposium Room: 6A

Business Meeting:  12:00 Noon - 12:30 PM PST

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8:35 AM Margaret E. Johnson, Johns Hopkins University, USA
Bending Membranes Along Distinct Pathways of Protein Assembly 

 

9:05 AM Juyong Lee, Seoul National University, South Korea
Accurate Prediction of Protein-Ligand Interactions by Combining Physical Energy Functions and Graph-neural Networks 

 

9:35 AM Frauke Graeter, Heidelberg University, Germany
Incorporating Chemistry into Classical Molecular Dynamics Simulations of Proteins by Machine Learning 

 

10:20 AM Early Career Award Talk: Giulia Palermo, University of California, Riverside, USA
Unraveling the CRISPR-Cas Revolution through the Lens of Computational Biophysics 

 

10:50 AM Mid-Career Award Talk: Xuhui Huang, University of Wisconsin–Madison, USA
Generalized Master Equation Models to Study Functional Dynamics of Proteins 

 

11:20 AM Janice Robertson, Washington University in St. Louis, USA
Building a Molecular Model for Ion Channel and Transporter Stability in Membranes through a Partnership of Experiments and Computation