2023 Satellite Meeting
Drug Discovery for Ion Channels XXIII

Friday, February 17, 8:30 AM - 4:35 PM
Room 8, San Diego Convention Center

Early Registration is now closed. There will be on-site registration. 

Ion channels are an important class of therapeutic drug targets, and mutations in ion channel genes are found to be responsible for an increasing number of diseases.  While conventional electrophysiological techniques permit the most detailed and direct study of ion channel function, they are limited due to the manual nature of the method and their low throughput.  Because of this, ion channels remain an underrepresented target class for drug discovery. 

The advent of higher throughput automated electrophysiology systems changed the face of ion channel drug discovery.  Since the inaugural “Drug Discovery for Ion Channels” satellite meeting, there have been many advances in ion channel drug discovery including new instrumentation and techniques.  For this year, we propose to continue the “Satellite Meeting” tradition at the Biophysical Society Annual Meeting and review the advances ion channel drug discovery. 

This year’s meeting will highlight presentations from drug discovery companies, companies that provide ion channel services to drug discovery companies and companies that provide products to ion channel drug discovery companies, as well as other speakers in the field of ion channel drug discovery, including several academic speakers. 



8:00 AM

Registration and Coffee
8:30 AM Welcome and Opening Remarks
Daniel Sauter, Sophion Bioscience, Denmark

8:45 AM - 9:30 AM

Keynote Speaker
Teresa Giraldez,
University of La Launa & Institute of Biomedical Technologies, Spain
Molecular Basis and Function of BK-Calcium Subcellular Domains as Modulators of Plasticity in the Brain

Session I 

Niels Fertig, Nanion Technologies, Germany, Chair

9:30 AM - 10:00 AM

Megan Yajuan, Case Western Reserve University, USA
Pharmacological Chaperones Restore the Trafficking and Function of Pathogenic GABAA Receptors

10:00 AM - 10:30 AM

Brittany Spitznagel, Vanderbilt University, USA
Characterization of Small Molecule Modulators of KNa Channels Using Automated Patch Clamp 

10:30 AM - 11:00 AM

Coffee Break
Session II Ali Yehia, Fluxion Biosciences, USA, Chair
11:00 AM - 11:30 AM Sam Goodchild, Xenon Pharmaceuticals, Canada
Molecularly Selective NaV1.1 Potentiators Increase PV+ Fast-Spiking Interneuron Excitability and Restore Motor Performance in a Mouse Model of Dravet Syndrome
11:30 AM - 12:00 PM Andrew Riley, University of Illinois, USA
Antagonizing nAChRs to Treat Pain and Addiction  
12:00 PM - 12:30 PM Filip Van Petegem, University of British Columbia, Canada
Structural and Functional Investigation of Mechanical Coupling between L-type Calcium Channels and Ryanodine Receptors  
12:30 PM - 1:30 PM Lunch
Session III

Daniel Sauter, Sophion Bioscience, Denmark, Chair

1:30 PM - 2:00 PM

Péter Lukács, Centre for Agricultural Research, Martonvásár, Hungary
Advanced Patch Clamp Protocol Designs to Reveal Hidden Details of Ion Channel-Drug Interactions

2:00 PM - 2:30 PM Mike Poslusney, Lieber Institute for Brain Development, USA
Peripherally-Restricted GABA-A Modulators for the Treatment of IBS and Visceral Pain
2:30 PM – 3:00 PM Gildas Loussouarn, Nantes Université
In vivo Control of Skeletal Muscle Contraction and Heart Rhythm using Photosensitive Caged Natural Peptides
3:00 PM - 3:30 PM Coffee Break
Session IV Robert Kirby, Metrion Biosciences, United Kingdom, Chair
3:30 PM - 400 PM Nina Ottoson, Linköping University, Sweden
Development of new KV7.2/7.3 Channel Activators
4:00 PM - 4:30 PM Manoj Patel, University of Virginia, ISA
Gain-of-Function Mutations in Nav1.6 and Epileptic Seizures  
4:30 PM - 4:35 PM Closing Remarks
Niels Fertig, Nanion Technologies, Germany

Sponsored by: