Subgroup Saturday

Subgroup Co-Chairs:  Miguel Aon, Johns Hopkins University, USA and Gyorgy Csordas, Thomas Jefferson University, USA

Symposium Time:  10 AM - 2 PM EST

Subgroup Business Meeting:  9 AM - 10 AM EST

Symposium Co-Chairs:  Miguel Aon, John Hopkins University, USA and Sonia Cortassa, National Institute on Aging, NIH, USA

Symposium Title:  Mitochondrial and Metabolic Mechanisms of Lifespan and Healthspan Extension

 

10:10 AM Deborah M. Muoio, Duke University Medical Center, USA

Mitochondrial Adaptations to Bioenergetic Stress ​

 

10:45 AM John Denu, University of Wisconsin - Madison, USA

Mitochondrial Metabolism and the Epigenome

 

11:20 AM Plácido Navas, Universidad Pablo de Olavide, Spain

CoQ Homeostasis in Metabolic and Mitochondrial Disorders

 

12:20 PM Young Bioenergeticist Award Presentation

 

12:40 PM Rafael de Cabo, National Institute on Aging, NIH, USA

The Impact of NAD(P)H: Quinone Oxidoreductase 1 (NQO1) on Health and Mitochondrial, Glucose and Lipid Metabolism

 

1:15 PM Ann Chiao, Oklahoma Medical Research Foundation, USA

Mitochondrial Function in Cardiac Aging and Healthspan

Subgroup Chair: Samir Iqbal, University of Texas, Arlington

Symposium Time:  2 PM - 6 PM EST

Subgroup Business Meeting:  6 PM - 6:30 PM EST

 

2:00 PM Xiaoting Jia, Virginia Tech, USA

Flexible Multifunctional Fibers for Brain Interfacing

 

2:45 PM Andrew Ferguson, University of Chicago, USA

Reconstructing Protein Structure and Dynamics from Experimental Observable

 

3:30 PM Postdoc Recognition

 

4:30 PM Salman Khetani, University of Illinois at Chicago, USA

Engineering Miniature Human Tissues for Disease Modeling and Drug Development

 

5:15 PM Ahmad (Mo) Khalil, Boston University, USA

Design of Eukaryotic Gene Regulatory Circuits

Subgroup Chair: Jay Knutson, National Heart, Lung, and Blood Institute, NIH, USA 

Symposium Time: 2:00 PM - 6:00 PM EST

Subgroup Business Meeting: 3:15 PM - 3:30 PM EST

 

2:05 PM Tribute to Arthur G. Szabo

 

2:15 PM Marcelo Nollman, CNRS - Montpelier, France

Through the Looking-glass: Imaging-based Chromosome Conformation Capture in Single Cells

 

2:45 PM Paola Borri, Cardiff University, United Kingdom

Coherent Raman Scattering Microscopy for Quantitative Label-free Bioimaging

 

3:30 PM Giuseppe Vicidomini, Italian Institute of Technology, Italy

Laser-Scanning Microscopy with Single-Photon Detector Array: Deconstructing the Photon Stream from Your Fluorescence Sample

 

4:00 PM Thorsten Wohland, National University of Singapore - Centre for BioImaging Sciences, Singapore

Beyond Imaging FCS: Multi-parametric Fluorescence Microscopy

 

4:30 PM Rapid Fire Talks

 

4:55 PM Young Fluorescence Investigate Awardee Presentation

 

5:25 PM Weber Awardee Presentation

Subgroup Chair: Daniel Harries, Hebrew University of Jerusalem, Israel

Program Co-Chairs: Silvia Cavagnero, University of Wisconsin-Madison, USA and Bin Zhang, Massachusetts Institute of Technology, USA

Symposium Time: 10:00 AM - 2:00 PM EST

 

10:05 AM Jennifer Lippincott-Schwartz, Howard Hughes Medical Institute, USA

Mitochondria Health and Deterioration under Nutrient Stress Depend on Lipid Trafficking Pathways set up and Controlled by Vacuolar Phase-separated, Sterol-rich Microdomain

 

10:45 AM Grant Jensen, California Institute of Technology, USA

Imaging Biopolymers in vivo directly with Cryo-ET: Trim5 Nets and IRE-1 Helices

 

11:20 AM Lucia Strader, Duke University, USA

Condensation of a Plant Transcription Factor Driven by an Oligomerization Domain and IDR

 

11:45 AM Junior Investigator Awardee Presentation: Stephen Fried, Johns Hopkins University

Non-Refoldability is Pervasive Across the E. Coli Proteome

 

12:20 PM Ivan Volkov, Uppsala University

Live-Cell Single-Molecule Tracking of the Translation Machinery

 

12:40 PM Iva Tolic, Ruder Boskovic Institute, Croatia

Optogenetic Control of Spindle Microtubule Crosslinkers Reveals that Bridging Fibers Promote Chromosome Alignment by Overlap Length-Dependent Forces

 

1:05 PM Jose Onuchic, Rice University, USA

Energy Landscapes, Order and Disorder, and Protein Sequence Coevolution: From Proteins to Chromosome Structure

Subgroup Chair: Lucia Sivilotti, University College London, United Kingdom

Symposium Time: 10:00 AM - 2:00 PM EST

Subgroup Business Meeting: 12:05 PM - 12:35 PM EST

 

10:00 AM John Baenziger, Ottawa University, Canada

The Structural Basis for Lipid-Sensing in a Pentameric Ligand-Gated Ion Channel

 

11:00 AM Han Chow Chua, Copenhagen University, Denmark

Structure and Function of the Human Sodium Leak Channel NALCN

 

10:30 AM Anna Duncan, Oxford University, United Kingdom

Jostling for Position: Defining How Multiple Lipid Species Interact with Inward Rectifier Potassium (Kir) Channels

 

11:30 AM Kirill Nadezhdin, Columbia University, USA

Structure and Function of TRPV Channels

 

12:45 PM Richard Lewis, Stanford University, USA

Cole Award Lecture

Subgroup Chair: Charles (Chuck) Sindelar, Yale University, USA    

Program Co-Chairs: Michael Cianfrocco, University of Michigan, USA and Andres Leschziner, University of California - San Diego, USA

Symposium Time: 2:00 PM - 6:00 PM EST

Subgroup Business Meeting & Virtual Happy Hour: 6:00 PM - 7:00 PM EST

 

2:05 PM Keynote Speaker: Helen Saibil, Birkbeck University of London, United Kingdom

Cryo EM of Dynamic Complexes

 

2:35 PM Sharon G. Wolf, Weizmann Institute, Israel

Revealing Mitochondrial Architecture in Vitrified Cells by CryoSTEM Tomograph

 

2:57 PM Dimitry Tegunov, Max Planck Institute for Biophysical Chemistry - Göttingen, Germany

Resolving Protein Dynamics in situ with Deep Learning

 

3:19 PM Tristan Croll, Cambridge University, United Kingdom

Physics-based Interactive Model Building with ISOLDE

 

3:37 PM Lori A. Passmore, MRC Laboratory of Molecular Biology at Cambridge University, United Kingdom

Mechanistic Insights into Molecular Machines that Regulate Gene Expression

 

4:14 PM Gira Bhabha, New York University Langone Health, USA

Tunnels for Lipid Transport Across the Bacterial Cell Envelope

 

4:36 PM Yimo Han, Rice University, USA

Monolayer Graphene Grids Enable 2.6-Å Reconstruction of 52-kDa Streptavidin 

 

4:54 PM Lexi Walls, University of Washington, USA

Visualizing the SARS-CoV-2 Spike in Complex with Neutralizing Antibodies

 

5:12 PM Katerina Naydenova, MRC Laboratory of Molecular Biology at Cambridge University, United Kingdom

The Physics of Movement-free CryoEM

 

5:30 PM Radostin Danev, University of Tokyo, Japan

Pushing the Limits of Cryo-EM for G Protein-coupled Receptors

Subgroup Chair: Nicolas Fawzi, Brown University, USA

Program Co-Chairs: Robert Best, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA and Alessandro Borgia, St. Jude Children's Hospital, USA

Symposium Time: 2:00 PM - 6:00 PM EST

Subgroup Business Meeting: 9:00 AM - 10:00 AM EST

 

2:00 PM Keynote Speaker: Keith Dunker, Indiana University, USA (Founder of IDP Subgroup)

On the Evolution of IDRs, IDDs, and IDPs

 

2:35 PM Rosana Collepardo, Cambridge University, United Kingdom

Liquid-like Chromatin Organization from Multiscale Modelling

 

3:00 PM Beat Fierz, Ecole Polytechnique Fédérale de Lausanne, Switzerland

Dynamic Control Mechanisms of Local Chromatin Access

 

3:25 PM Hagen Hofmann, Weizmann Institute, Israel

Allostery through DNA Drives Phenotype Switching

 

3:50 PM Anne Bremer, St. Jude Childrens Research Hospital, USA

Talk title TBD

 

4:05 PM Alexander K. Buell, Technical University of Denmark

The Thermodynamics of Misfolding into Amyloid Fibrils

 

4:30 PM Rebecca B. Berlow, Scripps Research Institute, USA

Pathways of Amyloid Formation in Solution and on Lipid Membranes

 

4:55 PM Matthew King, Washington University in St. Louis, USA

Talk title TBD

 

5:10 PM Allie Obermeyer, Columbia University, USA

Design of Protein-based Complex Coacervates in Cells

 

5:35 PM Wenwei Zheng, Arizona State University, USA

Computational Models for Liquid-Liquid Phase Separation of Intrinsically Disordered Proteins

Subgroup Chair: Catherine Musselman, University of Colorado - Anschutz, USA

Symposium Time: 2:00 PM - 6:00 PM EST

Subgroup Business Meeting: 6:00 PM - 6:30 PM EST

 

2:05 PM Lovorka Stojic, Queen Mary University of London, United Kingdom

Long Noncoding RNAs: New Guardians of Genome Integrity During the Cell Cycle

 

2:35 PM Carlos A. Castañeda, Sryacuse University, USA

Function and Mechanisms of UBQLN2-mediated Phase Transitions in Protein Quality Control

 

3:05 PM Anna-Lena Steckelberg, Columbia University, USA

Viral Manipulation of Translation and RNA Turnover

 

3:35 PM Robb Welty, Washington University in St. Louis, USA

Talk title TBD

 

4:00 PM Vignesh Kasinath, University of California - Berkeley, USA

Structural Insights into the Regulation of Gene Silencer PRC2

 

4:30 PM Aaron Hoskins, University of Wisconsin, USA

Using Single Molecules to Map the Pathways of Spliceosome Active Site Formation

 

5:00 PM Cheryl Kerfeld, Lawrence Berkeley National Lab, USA

Diversity, Structure, Function, Assembly and Engineering of Primitive Protein-Based Organelles: Bacterial Microcompartments

 

5:30 PM Sarah Leininger, Penn State, USA

Talk title TBD

 

5:45 PM Flash Talks from Honglue Shi, Duke University USA; Xinyu (Ashlee) Feng, Johns Hopkins University, USA; Nesreen Elathram, University of California - San Diego, USA; and Brownwyn Lyons, University of British Columbia, Canada

Subgroup Chair: Michael Sheetz, Columbia University, USA       

Symposium Time: 10:00 AM - 2:00 PM EST

Subgroup Business Meeting: 6:00 PM - 7:00 PM EST

 

10:05 AM Keynote Speaker: Xavier Trepat, IBEC Barcelona, Spain

Mechanical Multitasking: The Forces that Enable Epithelia to Fold, Migrate, Divide and Die

 

10:40 AM Early Career Awardee Presentation

 

11:05 AM Sara Wickström, University of Helsinki, Finland

Nuclear Mechanotransduction: Regulation of Cell Fate and Integrity

 

11:35 AM Celeste Nelson, Princeton University, USA

How to Build an Epithelial Tree

 

12:05 PM Invited Speaker TBD

 

12:23 PM Lisa Manning, Syracuse University, USA

Geometric Signatures of Heterotypic Cell-Cell Interactions in Confluent Tissues

 

12:41 PM Matthew J. Paszek, Cornell University, USA

Control of Membrane Morphological Transitions by the Glycocalyx 

 

12:59 PM Sweta Murthy, Oregon Health & Science University - Vollum Institute, USA

The Molecular Basis of Mechanically Activated Ion Channels OSCAs

 

1:17 PM Stuti Desai, University of Texas Medical Branch, USA

Collective Behavior of Salmonella in Persistent Infections

 

1:29 PM Omer Shafraz, University of California - Davis, USA

Mapping Transmembrane Binding Partners for E-cadherin Ectodomains

 

1:41 PM Bob Fregin, University of Greifswald, Germany

Talk Title TBD

Subgroup Chair:  Jenny Hinshaw, National Institute of Diabetes and Digestive Kidney Diseases, NIH, USA

Symposium Time: 10:00 AM - 2:00 PM EST

Subgroup Business Meeting: 11:20 AM - 11:35 AM EST

 

10:05 AM David DiGregorio, Institut Pasteur, France

Mechanisms Underlying the Diversity of Calcium-dependent Synaptic Vesicle Fusion Dynamics

 

10:30 AM Dragomir Milovanovic, German Center for Neurodegenerative Diseases (DZNE), Germany

A Phase of Synapsin and Synaptic Vesicles Recruits Alpha-Synuclein

 

10:55 AM Elizabeth Chen, University of Texas - Southwestern, USA

Mechanical Tension Drives Cell-Cell Fusion

 

11:35 AM Gregory Melikian, Emory University, USA

Inhibition of Viral Fusion by Interferon-induced Transmembrane Proteins

 

12:00 Noon Adam Frost, University of California - San Francisco, USA

Membrane Mechanics: New Insights from CryoEM and CryoEM-guided Simulations

 

12:25 PM Simon Scheuring, Weill Cornell Medicine, USA

High-speed AFM: Membrane Deformation Protein Complexes in Action

 

12:50 PM Carole Parent, University of Michigan, USA

Extracellular Vesicles as Key Regulators of Dictyostelium and Neutrophils Chemotaxis

 

1:15 PM Sir Bernard Katz Awardee: Joshua Zimmerberg, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, USA

The Pathway for Membrane Fusion and Fission in Exocytosis and Viral Entry

Subgroup Chair: Sarah Veatch, University of Michigan, USA 

Symposium Time: 2:00 PM - 6:00 PM EST

Subgroup Business Meeting: 6:00 PM - 7:00 PM EST

 

Part One: Celebrating Foundations

2:10 PM Félix Goñi, Basque Center for Biophysics (EHU), Spain

Can we Dispense with Sphingolipids? Correlation between Membrane Lipid Composition and Biophysical Properties in Sphingolipid-restricted Mammalian Cells

 

Part Two: Domains in Signaling

2:30 PM Ana J. Garcia-Saéz, University of Cologne, Germany

Interplay between the Cellular Machinery for Apoptosis and Mitochondrial Division

 

2:45 PM Sarah Shelby, University of Michigan, USA

Immune Receptors and the Membrane Microenvironment

 

Part Three: Chemical Activity of Membrane Components

3:30 PM Fredric Cohen, Rush University, USA

Dynamic Regulation of the Chemical Potential of Plasma Membrane Cholesterol by Growth Factors

 

3:45 PM Martin Girard, Max Planck Institute for Polymer Research - Mainz, Germany

Insights into Regulation of Cell Membranes through Regulated Ensembles

 

4:00 PM Kristen A. Johnson, University of Texas - Southwestern, USA

Cholesterol Accessibility in Membranes

 

Part Four: Protein Phase Separation at Membranes

4:30 PM Benjamin Machta, Yale University, USA

(Pre)Wetting of Protein Droplets to Critical Membranes

 

4:45 PM Feng Yuan, University of Texas - Austin, USA

Membrane Bending by Protein Phase Separation

 

Part Five: Thompson Award

5:35 PM Markus Deserno, Carnegie Mellon University, USA

Subgroup Chair:  Ming Zhou, Baylor College of Medicine, USA

Symposium Time: 2:00 PM - 6:00 PM EST

Subgroup Business Meeting: 5:40 PM - 6:15 PM EST

 

2:05 PM Oliver Beckstein, Arizona State University, USA

The Transport Cycle of a Sodium/Proton Antiporter

 

2:30 PM Nancy Carrasco, Vanderbilt University, USA

Talk title TBD

 

2:55 PM Noah Trebesch, University of Illinois at Urbana-Champaign, USA 

Mechanistic Insights from Molecular Dynamics Simulations of Large-Scale Conformational Transitions in the INDY Transport Cycle 

 

3:10 PM Susan K. Buchanan, National Institute of Diabetes and Digestive and Kidney Disease, NIH, USA 

Structural Insight into Ton Motor Complexes

 

4:10 PM David Drew, Stockholm University, Sweden

The molecular determinants for unlocking substrate translocation in GLUT transporters

 

4:35 PM Han Sun, Leibniz Research Institute for Molecular Pharmacology (FMP) - Berlin, Germany 

Ion Permeation in Non-selective Cation Channels 

 

5:00 PM Kavita Iyer, Virginia Commonwealth University, USA 

Cyro-EM and Functional Studies of RyRs Carrying Mutations Leading to "Leaky" Phenotype 

 

5:15 PM Hiro Furukawa, Cold Spring Harbor Laboratory, USA

Architecture and Function of Neuronal Machinery

Subgroup Co-Chairs:  Sanford (Sandy) Bernstein, San Diego State University, USA, and Kenneth (Ken) Campbell, University of Kentucky, USA

Symposium Time: 2:00 PM - 6:00 PM EST

Subgroup Business Meeting: 5:05 PM - 5:20 PM EST

 

2:05 PM Michael J. Greenberg, Washington University in St. Louis, USA

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

 

2:25 PM Nikki Reinemann, University of Mississippi, USA

Probing Hierarchical Cytoskeletal Ensembles Using Optical Tweezers

 

2:45 PM Thomas Kampourakis, King's College London, United Kingdom

The N-terminal Lobe of the Myosin Regulatory Light Chain is Part of a Sarcomeric Length Sensor in Cardiac Muscle

 

3:05 PM Melissa Gardner, University of Minnesota, USA

A Tug-of-War at the Plus-end: Kinesin-14 Motors and Plus-end Microtubule Dynamics

 

3:25 PM Krishna Chinthalapudi, Ohio State University Medical College, USA

Structural Basis of Nonmuscle Myosin-2 Regulation

 

3:45 PM Joseph Atherton, King's College London, United Kingdom

The Mechanism of Selective Kinesin Inhibition by Kinesin Binding Protei

 

4:05 PM Nadia Daneshparvar, Florida State University, USA

Cryo-EM Structure of Drosophila Thick Filaments

 

4:25 PM Jing Xu, University of California - Merced, USA

Cholesterol in Cargo Membrane Amplifies Inhibitory Effect of MAP tau on Kinesin-1

 

4:45 PM Andrew Mead, University of Vermont, USA

A Quick Tail: Larval Zebrafish Muscles are a See-through Window into Mechanisms of Contractile Modulation

 

5:20 PM Motility & Cytoskeleton Early Career Award Winner: Marija Zanic, Vanderbilt University, USA

Dynamic Architecture of the Microtubule Cytoskeleton: Understanding by Building

Subgroup Co-Chairs: Tom C. Bishop, Louisiana Tech University, USA, and Tamar Schlick, New York University, USA

Symposium Time: 10:00 AM - 2:00 PM EST

Subgroup Business Meeting: 1:25 PM - 2:00 PM EST

 

10:05 AM Catherine Musselman, Colorado University - Anschutz, USA

Chromatin Signaling: the Importance of Histone Tail Conformation

 

10:30 AM Garegin Papoian, University of Maryland, USA

Nucleosomal Physics from Electrostatics to Elasticity 

 

10:55 AM Lars Nordenskiöld, Nanyang Technical University, Singapore

Structure and Dynamics of Telomeric Chromatin 

 

11:20 AM Helmut Schiessel, Leiden University, Netherlands

Demultiplexing Information Written Along DNA Molecules

 

11:45 AM Hitoshi Kurumizaka, University of Tokyo, Japan

Nucleosome Contribution to Epigenetic Genome Regulation

 

12:10 PM Yamini Dalal, National Cancer Institute, NIH, USA

Bungee Jumping into Fragile Sites in the Human Cancer Genome: Mapping Nano-elasticity of Variant Chromatin Structure

 

12:35 PM Michele Di Pierro, Northeastern University, USA

Across Space and Along Polymers: Epigenetics’ Conflicting Means of Shaping Chromosomes

 

1:00 PM Andrzej Stasiak, University of Lausanne, Switzerland

Topological Analysis of Chromosomal Tracings, Obtained by Serial Fluorescent in situ Hybridization Method, Suggests that Human Chromosomes are Unknotted 

Subgroup Chair: Frederik Westerlund, Chalmers University, Sweden

Symposium Time: 10:00 AM - 2:00 PM EST

Subgroup Business Meeting: 1:50 PM - 2:00 PM EST

 

10:05 AM Aleksandra Radenovic, Ecole Polytechnique Fédérale de Lausanne, Switzerland

Correlative 3D Microscopy of Single Cells using Super-Resolution and Scanning Ion-Conductance Microscopy

 

10:35 AM Felix Rico, University of Aix-Marseille, France

Dynamics and Binding Strength of the Spike Protein of SARS-CoV-2 Probed by High-speed Atomic Force Microscopy

 

11:05 AM Prakash Shrestha, Boston Children's Hospital & Harvard Medical School, USA

Talk title TBD

 

11:25 AM Ilaria Testa, KTH Royal Institute of Technology, Sweden

3D Optical Nanoscopy in Living Cells

 

12:10 PM Mark Williams, Northeastern University, USA

Human FACT Proteins Facilitate both Disassembly and Reassembly of Nucleosomes

 

12:40 PM Andrew Barentine, Yale University, USA

Talk title TBD

 

1:00 PM Courtney Johnson, Duke University, USA

Talk title TBD

 

1:20 PM Bianxiao Cui, Stanford University, USA

Nanoscale Structures Modulating Cell Signaling at the Nano-Bio Interface