Subgroup Saturday

Subgroup Co-Chairs:  Karin Busch, University of Muenster, Germany and Tatiana Rostovtseva, NIH, USA

Program Co-Chairs:  Brian O'Rourke, Johns Hopkins Medicine, USA and Evgeny Pavlov, New York University, USA

Symposium Title:  Mitochondrial Ion Channels

San Diego Convention Center Rooms:  24 ABC

Symposium Time:  8:25 AM - 12:30 PM

Business Meeting:  12 noon - 12:30 pm

Speakers

9:30 AM - Diego De Stefani, University of Padova, Italy

ATP-Sensitive Channels in the Inner Mitochondrial Membrane

 

9:00 AM - Harpreet Singh, Ohio State University, College of Medicine

Mitochondrial Chloride Intracellular Channels in Cardioprotection

 

9:30 AM - Shey-Shing Sheu, Thomas Jefferson University

Distinctive Characteristics and Functions of Multiple Ca2+ Channels in Cardiac Mitochondria

 

10:15 AM - Steven J. Sollott, NIH, National Institute on Aging

K+- and H+-Fluxes Drive ATP Synthesis in Mammalian ATP Synthase

 

10:45 AM - Nelli Mnatsakanyan, Yale School of Medicine

Structural and Pharmacological Characterization of Mitochondrial Permeability Transition Pore: A Megachannel Formed by F1FO-ATP Synthase

 

11:15 AM - Jason Karch, Baylor College of Medicine

Genetic Inhibition of the Mitochondrial Permeability Transition Pore

 

11:45 AM - Young Bioenergeticist Award

Subgroup Chair: Raphael Lee, University of Chicago

San Diego Convention Center Room: 23 ABC

Symposium Time: 1:30 - 5:30 PM

Business Meeting: 3:05 - 3:30 PM
 

Speakers

1:35 PM - John P. Wikswo, Vanderbilt University

Multi-Omics and Automated Microfluidic Pumps and Valves for Controlling and Reverse Engineering of Biological Systems

 

2:05 PM - H. Steven Wiley, Pacific Northwest National Laboratory

Modulating Cell Protein Abundance to both Understand and Manipulate Biological Networks

 

2:35 PM - Taher Saif, University of Illinois at Urbana-Champaign

An in vitro 3D Neuro Muscular Platform Reveals Crosstalk between Neural Networks and Muscles

 

3:30 - Postdoc Recognition

 

3:50 PM - Yasser Aboelkassem, University of California, San Diego

A Stochastic Multiscale Model of Cardiac Muscle Biophysics using Brownian-Langevin Dynamics

 

4:20 PM - Zuzanna S. Siwy, University of California, Irvine

Nanopores and Channels for Biomimetics and Biomedical Engineering

 

4:50 PM - Andrew D. McCulloch, University of California, San Diego

Multi-scale Modeling of Therapeutic Mechanisms for Heart Failure

Subgroup Chair: Diane Lidke, University of New Mexico

San Diego Convention Center Room: 25 ABC

Symposium Time: 1:30 - 5:30 PM

Business Meeting: 3:20 - 3:30 PM

Speakers

1:35 PM - Suzanne Scarlata, Worcester Polytechnic Institute

Calcium signals, membrane tension and cell morphology: how basic biophysical principles govern neuronal plasticity

 

2:05 PM - Angelika Rück, Universität Ulm, Germany

Metabolic FLIM and Oxygen PLIM: Basics and Biomedical Applications

 

2:35 PM - George Harold Patterson, NIH, National Institute of Biomedical Imaging and Bioengineering

Photoswitching FRET Studies of Doxorubicin-Chromatin Interactions

 

3:30 PM - Diego Krapf, Colorado State University

Spatiotemporal Dynamics of Membrane Receptors at the Nanoscale

 

4:00 PM - Sandrine Lévêque-Fort, CNRS, Institut des Sciences Moléculaires d’Orsay, Université Paris-Sud, France

Playing with Fluorescence Emission for Enhanced Superresolution Microscopy

4:25 PM - Selected Rapid Fire Talks from poster abstracts

George Hamilton, Clemson University

Taryn Kay, University of Minnesota - Duluth

Jia Hui Li, Freie Universität Berlin, Germany

Manjari Mishra, Indian Institute of Technology Bombay, India

 

4:45 PM - Young Fluorescence Investigator Award & Lecture: Jelle Hendrix, University of Hasselt, Belgium

 

5:05 PM - Gregorio Weber Award & Lecture: Paul Selvin, University of Illinois

Subgroup Chair: Zaida Luthey-Schulten, University of Illinois, USA

Program Co-Chairs: Kendra Frederick, UT Southwestern, USA and Lynette Cegelski, Stanford, USA

San Diego Convention Center Room: 23 ABC

Symposium Time: 8:30 AM - 12:30 PM

Business Meeting: 8:30 - 9:00 AM

Speakers

9:05 AM - BIV Young Investigator Award

 

9:30 AM - Wolfgang Baumeister, Max Planck Institute of Biochemistry, Germany

Structural Biology ‘in situ’: The Promise and Challenges of Cryo-Electron Tomography

 

10:10 AM - Silvia Cavagnero, University of Wisconsin, Madison

Role of the Ribosome in Protein Folding and Aggregation

 

10:40 AM - Ramon Grima, University of Edinburgh, United Kingdom

Detailed Mathematical Models of Stochastic Gene Expression in Eukaryotic Cells

 

11:20 AM - Shana Elbaum-Garfinkle, City University of New York

Emergent Material Properties of Biopolymer Condensates

 

11:50 AM - Melinda Duer, University of Cambridge, United Kingdom

Heavy Mice and Lighter Things: Using Solid-state NMR to Study the Extracellular Matrix

Subgroup Chair: Crina Nimigean, Cornell University - Weill Medical College, USA

San Diego Convention Center Room: Ballroom 20 D

Business Meeting: 10:35 - 10:45 AM

Symposium Title: Ion Channel and Receptor Pharmacology: Insights from Correlating CryoEM Structures with Functional Data

Symposium Time: 8:30 AM - 12:30 PM

 

Speakers 

8:35 AM - Eduardo Perozo, University of Chicago

Mechanisms of Electromechanical Coupling in Non-Domain-Swapped Voltage Dependent Channels

 

9:05 AM - Vera Moiseenkova-Bell, University of Pennsylvania

Molecular Mechanisms of TRPV Channels Gating Revealed by Cryo-EM

 

9:35 AM - Georgios Skiniotis, Stanford University

CryoEM of GPCRs: from Molecular Mechanism to Drug Discovery

 

10:05 AM - Irina I. Serysheva, University of Texas, Health Science Center at Houston

Structural Insights into IP3R Gating and Regulation

 

11:00 AM - Anna Moroni, University of Milan, Italy

Open and Closed Pore Conformations of the Pacemaker Channel HCN4

 

11:30 AM - Sudha Chakrapani, Case Western Reserve University

Gating Mechanisms in Pentameric Ligand-Gated Ion Channels

 

12:00 noon - Richard Hite, Sloan Kettering Institute

Structures of the Non-Canonical lysosomal K+ Channel TMEM175

 

The Cole Award Reception & Dinner honoring Dr. Eduardo Perozo will be held at San Diego Water Grill, 615 J Street, from 6:00 pm until 9:00 pm. Advance tickets are required.

*ALL tickets are sold out as of 10/15/2019* To join the waitlist, please email [email protected] 

Subgroup Chair: Elizabeth Villa, University of California, San Diego, USA    

Program Co-Chairs: Elizabeth Kellogg, Cornell University and Melanie Ohi, University of Michigan Medical School

Symposium Title: Cryo-Electron Microscopy:  From Atoms to Cells and Beyond

San Diego Convention Center Room: 31 ABC

Symposium Time: 6:00 - 10:00 PM

Business Meeting: 6:49 - 7:04 PM

 

Speakers

6:05 PM - David DeRosier, Brandeis University

Where in the Cell is my Protein?

 

6:27 PM - Arne Möller, Max Planck Institute of Biophysics, Germany

The Conformational Dynamics of an ABC Transporter under Turnover Conditions

 

7:04 PM - Ariane Briegel, Leiden University, Netherlands

Cryo-Electron Tomography Contributes to our Understanding of Bacterial Interactions with their Environment

 

7:26 PM - Vignesh Kasinath, Helen Kay Whitney Postdoc Fellow at University of California, Berkeley

Structural Characterization of Large Macromolecular Complexes Regulating Chromosome Architecture and Gene Expression

 

7:44 PM - Kanika Khanna, PhD Candidate at University of California, San Diego

Regulation of Cell Division during Sporulation in Bacillus Subtilis

 

8:02 PM - Juergen M. Plitzko, Max Planck Institute of Biochemistry

Towards a Biopsy at the Nanoscale: Advances in Cryo-Electron Tomography for in situ Structural Biology of Cells and Tissues

 

8:39 PM - Bridget Carragher, Columbia University

CryoEM Automation: Better, Faster, Cheaper

 

9:01 PM - Christopher Barnes, HHMI Hanna Gray Postdoc Fellow at California Institute of Technology

Structures of HIV-1 Envelope Trimers Define Antibody-Mediated Neutralization of HIV-1

 

9:19 PM - Selected Abstract Speaker

 

9:37 PM - Nikolaus Grigorieff, HHMI Janelia Research Campus

Identification and Localization of Macromolecular Complexes in Cells by High-Resolution Template Matching

Subgroup Chair: M. Madan Babu, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom

Program Co-Chairs: Jane Clarke, University of Cambridge, United Kingdom, Zachary Levine, Yale School of Medicine, and Andrea Soranno, Washington Univeristy in St. Louis

San Diego Convention Center Room: 20 BC

Symposium Time: 1:30 - 5:30 PM

Business Meeting: 1:30 - 1:50 PM

 

Speakers

2:00 PM - Tuomas Knowles, University of Cambridge, United Kingdom

Probing proteins in small volumes

 

2:25 PM - Markus Zweckstetter, Max Planck Institute for Biophysical Chemistry, Germany

Liquid-Liquid Phase Separation of Intrinsically Disordered Proteins

 

2:55 PM - Postdoc Award Talk

 

3:10 PM - Postdoc Award Talk

 

3:40 PM - Priya R. Banerjee, University at Buffalo

Emergent Structure and Dynamics of Low-complexity Nucleoprotein Condensates

 

4:05 PM - Jeanne Stachowiak, University of Texas, Austin

Disordered Proteins as Catalysts of Membrane Traffic

 

4:30 PM - Jacqueline Matthews, University of Sydney, Australia

Kinetic Regulation of IDR-Protein Interactions in Transcription Regulation

 

4:55 PM - Yuh Min Chook, University of Texas, Southwestern Medical Center

Karyopherin as Chaperone

Subgroup Chair: Ilya Finkelstein, University of Texas, USA

San Diego Convention Center Room: Ballroom 20 A

Symposium Time: 1:30 - 5:30 PM

Business Meeting: 3:15 - 3:45 PM

 

Speakers

1:45 PM - Kendra Frederick, University of Texas, Southwestern Medical Center

In Cell Structural Biology of Protein Complexes using Sensitivity Enhanced Solid-State NMR

 

2:15 PM - David Taylor, University of Texas, Austin

Structures of Many Macromolecular Machines from a Single Cryo-EM Experiment

 

2:45 PM - Nadia Izadi Pruneyre, Pasteur Institute, France

Integrative Structural Biology of Bacterial Nano-Machines

 

3:00 PM - Alexandros Pertsinidis, Sloan Kettering Institute

Single Molecule Nanoscopy of RNA Pol II

 

3:45 PM - Edward Marcotte, University of Texas, Austin

Single-Molecule Protein Sequencing

 

4:15 PM - (Last Minute Cancellation) Speaker to be determined

 

4:45 PM - Yiwen Li, University of Oxford, UK

Label-free Single Molecule Quantification of DNA by Mass Photometry 

 

5:00 PM - Giulia Palermo, University of California - Riverside

Two-Metal Ion Mechanism of DNA Cleavage in CRISPR-Cas9 

Subgroup Chair: Xavier Trepat, IBEC Barcelona, Spain        

San Diego Convention Center Rooms: 30 ABC

Symposium Time: 8:30 AM - 12:30 PM

Business Meeting: 12:00 - 12:30 PM

Speakers

8:35 AM - Adam J. Engler, University of California, San Diego

Understanding and Exploiting Cancer Mechanobiology

 

9:05 AM - Jennifer A. Zallen, Sloan Kettering Institute

Signals, Forces, and Cells:  Decoding Tissue Morphogenesis

 

9:35 AM - Carsten Grashoff, Institute of Molecular Cell Biology, WMU Münster, Germany

Piconewton-Sensitive Biosensors to Investigate Adhesion Mechanics in Cells

 

10:05 AM - Saradha Venkatachalapathy, Mechanobiology Institute - National University of Singapore

 

10:20 AM - Mihai-Adrian Bodescu, Technical University of Munich, Germany

 

11:00 AM - Mechanobiology Award Presentation & Lecture: Yanlan Mao, MRC LCMB - University College London, UK

 

11:30 AM - Tai-De Li, City University of New York

 

11:45 AM - Elevator Talks: Chad Hobson, Rikki M. Garner, Krishna Chaitanya Kasuba

Subgroup Chair:  Ling-Gang Wu, NIH - NINDS, USA

San Diego Convention Center Rooms:  25 ABC

Symposium Time: 8:30 AM - 12:30 PM

Business Meeting: 11:20 - 11:35 AM

Speakers

8:35 AM - Erdem Karatekin, Yale School of Medicine

Dynamics of Membrane Tension and Synaptic Vesicle Recycling

 

9:00 AM - Michelle Knowles, University of Denver

Visualizing how SNARE Proteins Regulate Exosome Secretion

 

9:25 AM - Jonas Ries, European Molecular Biology Laboratory, Heidelberg, Germany

High-throughput Superresolution Microscopy of Endocytosis – Linking Molecular Architecture and Mechanics of a Protein Machinery

 

10:05 AM - Frédéric A. Meunier, Queensland Brain Institute, University of Queensland, Australia

Dynamic Nanoscale Organization of the Presynaptic Neurotransmitter Release Machinery

 

10:30 AM - Jakob Balslev Sørenson, University of Copenhagen, Denmark

Synaptotagmin-7 Places Vesicles at the Plasma Membrane to Promote Munc13-2 Dependent Priming

 

10:55 AM - Yifan Ge, Harvard Medical School

Two Forms of Opa1 Coordinate to Induce Mitochondrial Inner Membrane Fusion

 

11:35 AM - Richard Tsien, New York University School of Medicine

Sir Bernard Katz Award Lecture: Reallocation of Synaptic Weights by Resource Sharing

Subgroup Chair: Peter Tieleman, University of Calgary, Canada 

San Diego Convention Center Room: 30 ABC

Symposium Time: 1:30 - 5:30 PM

Business Meeting: 5:15 - 5:30 PM

 

Speakers

1:30 PM - Ana J. García-Sáez, Interfaculty Institute of Biochemistry, University of Tübingen, Germany

Membrane Permeabilization in Regulated Cell Death

 

2:00 PM - Fred A. Heberle, University of Tennessee

The Revolution Will Not be Symmetrized: Lessons from Asymmetric Model Membranes

 

2:30 PM - Ilya Levental, University of Texas Health Science Center at Houston

The lipidomic and biophysical asymmetry of the mammalian plasma membrane​

 

3:00 PM - Helgi I. Ingólfsson, Lawrence Livermore National Laboratory

Simulating Plasma Membranes: Effects of Leaflet Asymmetry and Compositional Complexity

 

3:45 PM - Janice L. Robertson, Washington University in St. Louis

Tuning CLC Dimerization in Membranes by Optimizing the Lipid Solvent

 

4:15 PM - Lutz Maibaum, University of Washington

Modeling Membrane Heterogeneities at Small and Large Length Scales

 

4:45 PM - Emad Tajkhorshid, Beckman Institute, University of Illinois, Urbana-Champaign

Thomas E. Thompson Award Lecture

 

Subgroup Chair:  Susan Rempe, Sandia National Laboratories, USA

San Diego Convention Center Room:  20 D

Symposium Time:1:25 PM - 5:30 PM

Business Meeting: 5:00 - 5:30 PM

 

Speakers

1:30 PM - Randy Stockbridge, University of Michigan

Evolution of Drug Export by the Small Multidrug Resistance Family of Transporters

 

2:00 PM - Jing Li, University of Chicago

Molecular Determinants of C-type Inactivation for the hERG Channel and Its Disease-Associated Mutants

 

2:15 PM - Fiona Naughton, Arizona State University

Bile acid transport by the symporter ASBT_NM: substrate binding and conformational change

 

2:30 PM - Katherine Henzler-Wildman, University of Wisconsin-Madison

Controlling the Rate and Efficiency of Proton-Coupled Transport by EmrE

 

3:15 PM - Grace Brannigan, Rutgers University

Ligand Binding in Membranes: A Clean Approach when Lipids are the Ligand, Solvent, and Concentration Scale

3:45 PM - Yang Suo, Duke University

Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel

 

4:00 PM - Kayce Tomcho, Duquesne University

Using a network of single site-specific cysteine mutations and crosslinking mass spectrometry (CXMS) to refine the structure and dynamics of the human alpha 1 glycine receptor (GlyR)

 

4:15 PM - Osamu Nureki, University of Tokyo, Japan

Structural Basis for Transport Cycle of P4 Flippase

 

4:45 PM - Closing Remarks

 

The Cole Award Reception & Dinner honoring Dr. Eduardo Perozo will be held at San Diego Water Grill, 615 J Street, from 6:00 pm until 9:00 pm. Advance tickets are required.

*ALL tickets are sold out as of 10/15/2019* To join the waitlist, please email [email protected] 

Subgroup Co-Chairs:  Michael Previs, University of Vermont, USA, Ahmet Yildiz, University of California, Berkeley, USA

Convention Center Rooms:  24 ABC 

Symposium Time: 1:30 - 5:20 PM and 8:00 - 9:30 PM 

Business Meeting: 3:15 - 3:40 PM

Speakers 

1:35 PM - Andrew Carter, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom: Dynein regulation

1:55 PM - Matthew Marzo, Colorado State University: Pac1/Lis1 Promotes Cytoplasmic Dynein Activity by Stabilizing its Open Conformation

2:05 PM - Sakthivel Sadayappan, University of Cincinnati, College of Medicine: Cardiac Myosin Binding Protein-C Regulates Cardiac Contractility

2:25 PM - Prince Tiwari, University of Massachusetts Medical School: Flexibility of Myosin II in Solution

2:35 PM - Gaia Pigino, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany: 3D Structure and Regulation of Intraflagellar Transport by CLEM and Cryo-EM

2:55 PM - Rui Zhang, Washington University in St. Louis: High-Resolution Cryo-EM Structure of the Decorated Ciliary Doublet Microtubule

3:40 PM - Jonathon Howard, Yale University: Roles of Vertical and Horizontal Forces on the Processivity of Motors

4:00 PM - Serapion (Ionas) Pyrpassopoulos, University of Pennsylvania Muscle Institute: Role of Off-axis Force in Motor Regulation

4:10 PM - Radhika Subramanian, Massachusetts General Hospital: Imaging Microtubule Arrays Using AFM

4:20 PM - Benjamin L. Prosser, University of Pennsylvania, Perelman School of Medicine: The Microtubule Network in Cardiac Hypertrophy and Heart Failure

4:40 PM - Alexander Dunn, Stanford University: A Molecular Mechanism for Symmetry Breaking at Cell-Cell Adhesion Complexes

5:00 PM - Darius Koester, Warwick University, UK: Bending of Actin Filaments into Rings by IQGAP Family of Proteins

5:10 PM - Jialong Jiang, California Institute of Technology: Motor-propelled Velocity Scaling in Active Microtubule Networks

5:40 - 7:40 PM - Networking Social at Smoking Gun San Diego, 555 Market St.

8:00 PM - Antonina Roll-Mecak, NIH, National Institute of Neurological Disorders and Stroke: Microtubule Dynamics: Not Only at the Tips

8:20 PM - Junior Faculty Award Presentation & Lecture - Richard McKenney, University of California, Davis

8:45 PM Keynote Speaker - David Thomas, University of Minnesota: Spectroscopic Probes of Muscle Proteins: Mechanistic Insights and Therapeutic Discovery

Subgroup Chair:  Ozgur Sahin, Columbia University

San Diego Convention Center Room:  Ballroom 20 BC

Symposium Time: 8:30 AM - 12:30 PM

Business Meeting:  12:20 - 12:30 PM

 

Speakers 

8:35 AM - Sam Peng, Stanford University

Long-term, Single-cargo Tracking in Live Neurons with Single-Molecular Step Resolution

 

9:05 AM - Rafael C. Bernardi, Beckman Institute - University of Illinois

Molecular Mechanisms of Extreme Mechanostability in Protein Complexes

 

9:35 AM - Shixin Liu, Rockefeller University

New Insights into DNA Replication Enabled by Correlative Single-Molecule Fluorescence and Force Microscopy

 

10:05 AM - Olga Dudko, University of California, San Diego

On the Border of Order: Chromosomal Organization in Space and Time

 

10:50 AM - Toshio Ando, Kanazawa University, Japan

High-Speed AFM Revealing Dynamic Biomolecular Processes

 

11:20 AM - Kamila R. Mustafina, McGill University, Canada

Sted Superresolution Imaging of DUOX1 and CEN2 Reveals Substructure of Membrane Macromolecular Complexes in Human Bronchial Epithelial Cells

 

11:35 AM - Sean P. Carney, University of Illinois, Urbana-Champaign

Direct Measurement of Stepping Dynamics of E. Coli UVRD Helicase

 

11:50 AM - Meni Wanunu, Northeastern University

Docking, Squeezing, and Unfolding Individual Native Proteins in a Solid State Nanopore

Subgroup Chair:  Julie S. Biteen, University of Michigan, USA

Program Chair:  Keng-hui Lin, Academia Sinica - Institute of Physics, Taiwan

San Diego Convention Center Rooms:  Ballroom 20 A

Symposium Time: 9:00 AM - 12:15 PM

Business Meeting: 12 Noon - 12:15 PM

 

Speakers:  

9:00 AM - Megan T. Valentine, University of California, Santa Barbara

Force Sensing and Regulation in Tissues - from Aggregates to Organisms

 

9:30 AM - Fangwei Si, University of California, San Diego

Mechanistic origin of cell-size control and homeostasis in bacteria

 

9:45 AM - Robert B. Phillips, California Institute of Technology

Schrodinger’s “What is life?” at 75: the Physical Aspects of the Living Cell Revisited

 

10:30 AM - Christine Jacobs-Wagner, Yale School of Medicine

Biophysical Properties of the Bacterial Cytoplasm

 

11:00 AM - Yuan-I (Nina) Chen, University of Texas at Austin

Comparison of in-vitro and in-vivo DNA hybridization kinetics using 3D single-molecule tracking

 

11:15 AM - Siddarth Reddy Karuka, University of Minnesota

Exclusion of RNA-associated proteins from the cell cortex observed by dual color z-scan fluorescence microscopy

 

11:30 AM - Antoine M. van Oijen, University of Wollongong, Australia

Tackling Antimicrobial Resistance, One Molecule at a Time