Subgroup Saturday

Subgroup Co-Chairs:  Karin Busch, University of Muenster, Germany and Tatiana Rostovtseva, NIH, USA

Program Co-Chairs:  Brian O'Rourke, Johns Hopkins Medicine, USA and Evgeny Pavlov, New York University, USA

Symposium Title:  Mitochondrial Ion Channels

San Diego Convention Center Rooms:  TBD

Business Meeting:  12 noon - 12:30 pm

Speakers

Diego De Stefani, University of Padova, Italy

ATP-Sensitive Channels in the Inner Mitochondrial Membrane

Jason Karch, Baylor College of Medicine

Genetic Inhibition of the Mitochondrial Permeability Transition Pore

Nelli Mnatsakanyan, Yale School of Medicine

Structural and Pharmacological Characterization of Mitochondrial Permeability Transition Pore: A Megachannel Formed by F1FO-ATP Synthase

Shey-Shing Sheu, Thomas Jefferson University

Distinctive Characteristics and Functions of Multiple Ca2+ Channels in Cardiac Mitochondria

Harpreet Singh, Ohio State University, College of Medicine

Mitochondrial Chloride Intracellular Channels in Cardioprotection

Steven J. Sollott, NIH, National Institute on Aging

K+- and H+-Fluxes Drive ATP Synthesis in Mammalian ATP Synthase

Subgroup Chair: Raphael Lee, University of Chicago

San Diego Convention Center Room: TBD

Business Meeting: 3:05 - 3:30 PM
 

Speakers

Yasser Aboelkassem, University of California, San Diego

A Stochastic Multiscale Model of Cardiac Muscle Biophysics using Brownian-Langevin Dynamics

 

Andrew D. McCulloch, University of California, San Diego

Multi-scale Modeling of Therapeutic Mechanisms for Heart Failure

 

Taher Saif, University of Illinois at Urbana-Champaign

An in vitro 3D Neuro Muscular Platform Reveals Crosstalk between Neural Networks and Muscles

 

Zuzanna S. Siwy, University of California, Irvine

Nanopores and Channels for Biomimetics and Biomedical Engineering

 

John P. Wikswo, Vanderbilt University

Multi-Omics and Automated Microfluidic Pumps and Valves for Controlling and Reverse Engineering of Biological Systems

 

H. Steven Wiley, Pacific Northwest National Laboratory

Modulating Cell Protein Abundance to both Understand and Manipulate Biological Networks

Subgroup Chair: Diane Lidke, University of New Mexico

San Diego Convention Center Room: TBD

Business Meeting: 3:20 - 3:30 PM

Speakers

Diego Krapf, Colorado State University

Spatiotemporal Dynamics of Membrane Receptors at the Nanoscale

 

Sandrine Lévêque-Fort, CNRS, Institut des Sciences Moléculaires d’Orsay, Université Paris-Sud, France

Playing with Fluorescence Emission for Enhanced Superresolution Microscopy

 

Satyajit Mayor, National Centre for Biological Sciences, Bangalore, India

Exploring the Skin of a Cell Using Fluorescence Microscopy Reveals an Active Membrane Composite

 

George Harold Patterson, NIH, National Institute of Biomedical Imaging and Bioengineering

Photoswitching FRET Studies of Doxorubicin-Chromatin Interactions

 

Angelika Rück, Universität Ulm, Germany

Metabolic FLIM and Oxygen PLIM: Basics and Biomedical Applications

Subgroup Chair: Zaida Luthey-Schulten, University of Illinois, USA

Program Co-Chairs: Kendra Frederick, UT Southwestern, USA and Lynette Cegelski, Stanford, USA

San Diego Convention Center Room: TBD

Business Meeting: 8:30 - 9:00 AM

Speakers

Wolfgang Baumeister, Max Planck Institute of Biochemistry, Germany

Structural Biology ‘in situ’: The Promise and Challenges of Cryo-Electron Tomography

 

Silvia Cavagnero, University of Wisconsin, Madison

Role of the Ribosome in Protein Folding and Aggregation

 

Melinda Duer, University of Cambridge, United Kingdom

Heavy Mice and Lighter Things: Using Solid-state NMR to Study the Extracellular Matrix

 

Shana Elbaum-Garfinkle, City University of New York

Emergent Material Properties of Biopolymer Condensates

 

Ramon Grima, University of Edinburgh, United Kingdom

Detailed Mathematical Models of Stochastic Gene Expression in Eukaryotic Cells

Subgroup Chair: Crina Nimigean, Cornell University - Weill Medical College, USA

San Diego Convention Center Room: TBD

Business Meeting: 10:35 - 10:45 AM

Symposium Title: Ion Channel and Receptor Pharmacology: Insights from Correlating CryoEM Structures with Functional Data

Symposium Time: 8:30 AM until 12:30 PM

 

Speakers 

Radu Aricescu, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom

The Structural Pharmacology of Human GABA_A Receptors

 

Sudha Chakrapani, Case Western Reserve University

Gating Mechanisms in Pentameric Ligand-Gated Ion Channels

 

Richard Hite, Sloan Kettering Institute

Structures of the Non-Canonical lysosomal K+ Channel TMEM175

 

Vera Moiseenkova-Bell, University of Pennsylvania

Molecular Mechanisms of TRPV Channels Gating Revealed by Cryo-EM

 

Eduardo Perozo, University of Chicago

Mechanisms of Electromechanical Coupling in Non-Domain-Swapped Voltage Dependent Channels

 

Irina I. Serysheva, University of Texas, Health Science Center at Houston

Structural Insights into IP3R Gating and Regulation

 

Georgios Skiniotis, Stanford University

CryoEM of GPCRs: from Molecular Mechanism to Drug Discovery

 

The Cole Award Reception & Dinner will be held at San Diego Water Grill, 615 J Street, from 6:00 pm until 9:00 pm. Advance tickets are required, and may be purchased online. *ALL tickets are sold out as of 10/15/2019*

Subgroup Chair: Elizabeth Villa, University of California, San Diego, USA    

Program Co-Chairs: Elizabeth Kellogg, Cornell University and Melanie Ohi, University of Michigan Medical School

San Diego Convention Center Room: TBD

Business Meeting: 6:49 - 7:04 PM

Symposium Title: Cryo-Electron Microscopy:  From Atoms to Cells and Beyond

Speakers

Christopher Barnes, HHMI Hanna Gray Postdoc Fellow at California Institute of Technology

Structures of HIV-1 Envelope Trimers Define Antibody-Mediated Neutralization of HIV-1

 

Ariane Briegel, Leiden University, Netherlands

Cryo-Electron Tomography Contributes to our Understanding of Bacterial Interactions with their Environment

 

Bridget Carragher, Columbia University

CryoEM Automation: Better, Faster, Cheaper

 

David DeRosier, Brandeis University

Where in the Cell is my Protein?

 

Nikolaus Grigorieff, HHMI Janelia Research Campus

Identification and Localization of Macromolecular Complexes in Cells by High-Resolution Template Matching

 

Vignesh Kasinath, Helen Kay Whitney Postdoc Fellow at University of California, Berkeley

Structural Characterization of Large Macromolecular Complexes Regulating Chromosome Architecture and Gene Expression

 

Kanika Khanna, PhD Candidate at University of California, San Diego

Regulation of Cell Division during Sporulation in Bacillus Subtilis

 

Arne Möller, Max Planck Institute of Biophysics, Germany

The Conformational Dynamics of an ABC Transporter under Turnover Conditions

 

Juergen M. Plitzko, Max Planck Institute of Biochemistry

Towards a Biopsy at the Nanoscale: Advances in Cryo-Electron Tomography for in situ Structural Biology of Cells and Tissues

Subgroup Chair: M. Madan Babu, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom

Program Co-Chairs: Jane Clarke, University of Cambridge, United Kingdom, Zachary Levine, Yale School of Medicine, and Andrea Soranno, Washington Univeristy in St. Louis

San Diego Convention Center Room: TBD

Business Meeting: 1:30 - 1:50 PM

Speakers

Priya R. Banerjee, University at Buffalo

Emergent Structure and Dynamics of Low-complexity Nucleoprotein Condensates

 

Yuh Min Chook, University of Texas, Southwestern Medical Center

Karyopherin as Chaperone

 

Tuomas Knowles, University of Cambridge, United Kingdom

 

Jacqueline Matthews, University of Sydney, Australia

Kinetic Regulation of IDR-Protein Interactions in Transcription Regulation

 

Jeanne Stachowiak, University of Texas, Austin

Disordered Proteins as Catalysts of Membrane Traffic

 

Markus Zweckstetter, Max Planck Institute for Biophysical Chemistry, Germany

Liquid-Liquid Phase Separation of Intrinsically Disordered Proteins

Subgroup Chair: Ilya Finkelstein, University of Texas, USA

San Diego Convention Center Room: TBD

Business Meeting: TBD

Speakers

Kendra Frederick, University of Texas, Southwestern Medical Center

In Cell Structural Biology of Protein Complexes using Sensitivity Enhanced Solid-State NMR

 

Yan Jie, Mechanobiology Institute, National University of Singapore

Understand and Modulate the Stability of Force-Transmission Cytoskeletal Supramolecular Linkages

 

David Taylor, University of Texas, Austin

Structures of Many Macromolecular Machines from a Single Cryo-EM Experiment

Subgroup Chair: Xavier Trepat, IBEC Barcelona, Spain        

San Diego Convention Center Rooms: TBD

Business Meeting: 12:15 - 12:30 PM

Speakers

Adam J. Engler, University of California, San Diego

Understanding and Exploiting Cancer Mechanobiology

 

Carsten Grashoff, Institute of Molecular Cell Biology, WMU Münster, Germany

Piconewton-Sensitive Biosensors to Investigate Adhesion Mechanics in Cells

 

Jennifer A. Zallen, Sloan Kettering Institute

Signals, Forces, and Cells:  Decoding Tissue Morphogenesis

Subgroup Chair:  Ling-Gang Wu, NIH - NINDS, USA

San Diego Convention Center Rooms:  TBD

Business Meeting: 11:20 - 11:35 AM

Speakers

Camin Dean, European Neuroscience Institute Göttingen, Germany

AMPA Receptor Endocytosis During Forgetting

 

Erdem Karatekin, Yale School of Medicine

Dynamics of Membrane Tension and Synaptic Vesicle Recycling

 

Michelle Knowles, University of Denver

Visualizing how SNARE Proteins Regulate Exosome Secretion

 

Frédéric A. Meunier, Queensland Brain Institute, University of Queensland, Australia

Dynamic Nanoscale Organization of the Presynaptic Neurotransmitter Release Machinery

 

Jonas Ries, European Molecular Biology Laboratory, Heidelberg, Germany

High-throughput Superresolution Microscopy of Endocytosis – Linking Molecular Architecture and Mechanics of a Protein Machinery

 

Jakob Balslev Sørenson, University of Copenhagen, Denmark

Synaptotagmin-7 Places Vesicles at the Plasma Membrane to Promote Munc13-2 Dependent Priming

 

Richard Tsien, New York University School of Medicine

Sir Bernard Katz Award Lecture

Subgroup Chair: Peter Tieleman, University of Calgary, Canada 

San Diego Convention Center Room: TBD

Business Meeting: 5:15 - 5:30 PM

Speakers

Ana J. García-Sáez, Interfaculty Institute of Biochemistry, University of Tübingen, Germany

Membrane Permeabilization in Regulated Cell Death

 

Fred A. Heberle, University of Tennessee

The Revolution Will Not be Symmetrized: Lessons from Asymmetric Model Membranes

 

Helgi I. Ingólfsson, Lawrence Livermore National Laboratory

Simulating Plasma Membranes: Effects of Leaflet Asymmetry and Compositional Complexity

 

Lutz Maibaum, University of Washington

Modeling Membrane Heterogeneities at Small and Large Length Scales

 

Anant Menon, Weill Cornell Medical College

Phospholipid Scramblases and Transbilayer Lipid Asymmetry

 

Janice L. Robertson, Washington University in St. Louis

Tuning CLC Dimerization in Membranes by Optimizing the Lipid Solvent

 

Emad Tajkhorshid, Beckman Institute, University of Illinois, Urbana-Champaign

Thomas E. Thompson Award Lecture

 

Subgroup Chair:  Susan Rempe, Sandia National Laboratories, USA

San Diego Convention Center Room:  TBD

Business Meeting: 5:00 - 5:30 PM

Speakers

Grace Brannigan, Rutgers University

Ligand Binding in Membranes: A Clean Approach when Lipids are the Ligand, Solvent, and Concentration Scale

 

José D. Faraldo-Gómez, NIH, National Heart Lung and Blood Institute

Membrane Morphology, Energetics & Dynamics at the Interface with Transport Proteins

 

Katherine Henzler-Wildman, University of Wisconsin-Madison

Controlling the Rate and Efficiency of Proton-Coupled Transport by EmrE

 

Osamu Nureki, University of Tokyo, Japan

Structural Basis for Transport Cycle of P4 Flippase

 

Randy Stockbridge, University of Michigan

Evolution of Drug Export by the Small Multidrug Resistance Family of Transporters

The Cole Award Reception & Dinner will be held at San Diego Water Grill, 615 J Street, from 6:00 pm until 9:00 pm. Advance tickets are required, and may be purchased online. **All tickets are SOLD OUT as of 10/15/19**

Subgroup Co-Chairs:  Michael Previs, University of Vermont, USA, Ahmet Yildiz, University of California, Berkeley, USA

San Diego Convention Center Rooms:  TBD

Business Meeting: 3:15 - 3:40 PM

Speakers 

Andrew Carter, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom

Dynein regulation

 

Alexander Dunn, Stanford University

A Molecular Mechanism for Symmetry Breaking at Cell-Cell Adhesion Complexes

 

Jonathon Howard, Yale University

Roles of Vertical and Horizontal Forces on the Processivity of Motors

 

Gaia Pigino, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

3D Structure and Regulation of Intraflagellar Transport by CLEM and Cryo-EM

 

Antonina Roll-Mecak, NIH, National Institute of Neurological Disorders and Stroke

Microtubule Dynamics: Not Only at the Tips

 

Benjamin L. Prosser, University of Pennsylvania, Perelman School of Medicine

The Microtubule Network in Cardiac Hypertrophy and Heart Failure

 

Sakthivel Sadayappan, University of Cincinnati, College of Medicine

Cardiac Myosin Binding Protein-C Regulates Cardiac Contractility

 

David D. Thomas, University of Minnesota

Spectroscopic Probes of Muscle Proteins: Mechanistic Insights and Therapeutic Discovery

 

Rui Zhang, Washington University in St. Louis

High-Resolution Cryo-EM Structure of the Decorated Ciliary Doublet Microtubule

Subgroup Chair:  Ozgur Sahin, Columbia University

San Diego Convention Center Room:  TBD

Business Meeting:  12:20 - 12:30 PM

Speakers 

Toshio Ando, Kanazawa University, Japan

High-Speed AFM Revealing Dynamic Biomolecular Processes

 

Olga Dudko, University of California, San Diego

On the Border of Order: Chromosomal Organization in Space and Time

 

Hermann E. Gaub, LMU München, Germany

Molecular Mechanisms of Extreme Mechanostability in Protein Complexes

 

Shixin Liu, Rockefeller University

New Insights into DNA Replication Enabled by Correlative Single-Molecule Fluorescence and Force Microscop

 

Sam Peng, Stanford University

Long-term, Single-cargo Tracking in Live Neurons with Single-Molecular Step Resolution

 

Meni Wananu, Northeastern University

Docking, Squeezing, and Unfolding Individual Native Proteins in a Solid State Nanopore

Subgroup Chair:  Julie S. Biteen, University of Michigan, USA

Program Chair:  Keng-hui Lin, Academia Sinica - Institute of Physics, Taiwan

San Diego Convention Center Rooms:  TBD

Business Meeting: 12 Noon - 12:15 PM

Speakers:  

Christine Jacobs-Wagner, Yale School of Medicine

Biophysical Properties of the Bacterial Cytoplasm

 

Robert B. Phillips, California Institute of Technology

Schrodinger’s “What is life?” at 75: the Physical Aspects of the Living Cell Revisited

 

Megan T. Valentine, University of California, Santa Barbara

Force Sensing and Regulation in Tissues - from Aggregates to Organisms

 

Antoine M. van Oijen, University of Wollongong, Australia

Tackling Antimicrobial Resistance, One Molecule at a Time