Program

Sunday, October 10, 2010

7:00- 9:00 PM
Welcome Reception

Monday, October 11, 2010

8:45–9:00 AM
Welcome to Beijing
The Organizing Committee
Mordecai P. Blaustein, Heping (Peace) Cheng, W. Jonathan Lederer and Zhuan Zhou

Welcome from the Biophysical Society of China and The Biophysical Society (US)
Xian-En Zhang,
vice director, Biophysical Society of China
Joesph J. Falke,
former president, The Biophysical Society

Session 1: Cell Migration, Cancer and Apoptosis
Session Co-Chairs
Joseph J. Falke,
University of Colorado, Boulder, CO, USA
Greg Monteith,
University of Queensland, Brisbane, Australia

9:00–9:10 AM

Mordecai P. Blaustein
, University of Maryland, Baltimore, Baltimore, MD, USA
Introduction to the Conference: A Half Century of Ca2+ Signaling– and the Horizon Looks Bright

9:10–9:35 AM
Heping Cheng, Institute of Molecular Medicine, Peking University, Beijing, China
Flickering Ca2+ Signals and Cell Migration

9:35–10:00 AM
Joseph J. Falke, University of Colorado, Boulder, CO, USA
Ca2+ Signaling and PKC Recruitment at the Macrophage Leading Edge

10:00–10:25 AM
Sarah J. Roberts-Thomson, University of Queensland,
Brisbane, Australia
Remodeling of Ca2+ Signaling in Tumorigenesis

10:25–10:45 AM
Coffee/Tea Break

10:45–11:10 AM
Donald Choi Chang, Hong Kong University of Science and Technology, Hong Kong, China
Ca2+ Signaling in Apoptosis


Session 2:  Ca2+ Signaling in Mitochondria; TRP Channels, Two Pore Channels and Ca2+ Signaling
Session Chair
David Clapham,
Harvard University, Boston, MA, USA

11:15–11:40 AM
David Clapham, Harvard University, Boston, MA, USA
Ca2+ Signaling in Mitochondria

11:40–12:05 PM
Uhtaek Oh, Seoul National University, Seoul, South Korea
Anoctamin 1/TMEM6A, a Cloned Ca2+-Activated Cl- Channel and its Structural Basis for Putative Ca2+ Action Sites

12:05–12:45 PM
Lunch

12:45–2:15 PM
Poster Session I

Session 2 (continued): Ca2+ Signaling in Mitochondria; TRP Channels, Two Pore Channels and Ca2+ Signaling

Session Co-Chairs
Jason X.-J. Yuan, University of Illinois, Chicago, Chicaog, IL, USA
Uhtaek Oh, Seoul National University, Seoul, South Korea

2:15–2:30 PM
Liangyi Chen*, Institute of Molecular Medicine, Peking University, Beijing, China
Graded Activation of CRAC Channel by Binding of Different Numbers of STIM1 to Orai1 Subunits

2:30–2:45 PM
Xiaoli Zhao*, University of Medicine and Dentistry of New Jersey, Piscataway, NJ,  USA
Orai1 Mediates Store-operated Ca2+ Entry in Normal Skeletal Muscle and Exacerbated Ca2+ Entry in Dystrophic Muscle

2:45–3:10 PM
Michael X. Zhu, University of Texas Health Science Center, Houston, TX, USA
Two-Pore Channels as Receptors for NAADP-induced Ca2+ Release from Acidic Organelles

3:10–3:25 PM
Zheng Xing Wu*, Huazhong University of Science and Technology, Huazhong, China
Differential Ca2+ Binding Rates in BK Channels

3:25–3:40 PM
Petronel Tuluc*, University of Innsbruck, Innsbruck, Austria
The Low-voltage-activated, High Amplitude Ca2+ Channel Splice Variant Cav1.1E29 Reveals the Molecular Mechanism Underlying the Specific Gating Behaviour of Cav1.1

3:40–4:00 PM
Coffee/Tea Break

Session 3:  Ca2+ Signaling and Secretion
Session Co-Chairs
Wolfhard Almers, Vollum Institute, Portland, OR, USA
Weiping Han, National University of Singapore, Singapore, Singapore

4:05 –4:30 PM
Wolfhard Almers, Vollum Institute, Portland, OR, USA
Interaction of SNARE Proteins with Single Granules in Live Cells

4:30–4:55 PM
Haruo Kasai, University of Tokyo, Tokyo, Japan
SNARE Conformational Changes that Prepare Vesicles for Exocytosis

4:55–5:20 PM
Weiping Han, National University of Singapore, Singapore
Molecular Regulation of Ca2+-dependent Insulin and Glucagon Secretion

5:20 –5:45 PM
Jennie Jie Yang, Center for Advanced Biotechnology & Drug Design, Georgia State University, Atlanta, GA, USA
Modulating Ca2+ Signaling by Protein Design

Evening Free 

Tuesday, October 12, 2010

7:30 AM-12:30 PM
Excursion to the Great Wall

12:30–1:45 PM
Lunch

Session 4:  Ca2+ Signalling and Secretion II
Session Chair
Jennie Jie Yang, Center for Advanced Biotechnology & Drug Design, Georgia State University, Atlanta, GA, USA

1:45–2:10 PM
Zhuan Zhou, Peking University, Beijing, China
Action Potential Pattern Modulates Presynaptic Glutamate Release in a Giant Synapse

2:10–2:35 PM
Minmin Luo, National Institute of Biological Sciences, Beijing, & School of Life Sciences, Tsinghua University, Beijing, China
Habenula ‘Cholinergic’ Neurons Co-release Glutamate and Acetylcholine and Activate Postsynaptic Neurons via Distinct Transmission Modes

Session 5: Ca2+ Signaling in Neurons
Session Co-Chairs
Diane Lipscombe, Brown University, Providence, RI, USA
Yi Zhong, Tsinghua University, Beijing, China & Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA

2:40–3:05 PM
Junichi Nakai, Saitama University Brain Science Institute, Saitama City, Japan
In vivo Imaging with Genetically-encoded Ca2+ Sensors

3:05–3:30 PM
David T. Yue, Johns Hopkins University, Baltimore, MD, USA
Genetically-Encoded Biosensors Reveal Enzyme-Inhibitor-Like Tuning of Ca2+ Channels

3:30-3:55 PM
Diane Lipscombe, Brown University, Providence, RI, USA
Alternative Spicing Controls G-protein Inhibition of Neuronal Ca2+ Channels

3:55 –4:15 PM
Coffee/Tea Break

Session 5 (continued): Ca2+ Signaling in Neurons
Session Co-Chairs
David Yue, Johns Hopkins University, Baltimore, MD, USA
Shumin Duan, Institute of Neurobiology, Zhejiang University, Hangzhou, China

4:15-4:40 PM
Ryohei Yasuda, Duke University, Durham, NC, USA
Visualizing Ca2+-dependent Signaling in Single Dendritic Spines

4:40-4:55 PM
Satoshi Manita*, RIKEN, Brain Science Institute, Waco City, Saitama, Japan
Interaction of Ca2+ Signaling Mechanisms in Pyramidal Cell Dendrites

4;55-5:10 PM
Kaiyu Zheng*, University College, London, United Kingdom
Calcium-dependent Astrocytic Signaling and Synaptic Function

5:10–5:35 PM
Shumin Duan, Institute of Neurobiology, Zhejiang University, Hangzhou, China
ATP Release from Astrocytes Mediates Hippocampal Heterosynaptic Long-Term Depression

5:35–6:00 PM
Yi Zhong, Tsinghua University, Beijing, China & Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
Food-detecting Neurons in Drosophila

Session 6:  Keynote Lecture

6:05–6:10 PM
Introduction: W. Jonathan Lederer

6:10–7:00 PM
Richard W. Tsien, Stanford University, Stanford, CA, USA
Deciphering the Differential Effectiveness of Ca2+ Channels in Excitation-Response Coupling

7:15  PM
Dinner

Wednesday, October 13, 2010

Session 7: Cardiac Muscle
Session Co-Chairs
W. Jonathan Lederer, Center for Biomedical Engineering & Technology, University of Maryland, Baltimore, MD, USA
Rui-Ping Xiao, Shenzen Graduate School, Peking University, Beijing, China

9:00–9:25 AM
W. Jonathan Lederer, Center for Biomedical Engineering & Technology, University of Maryland, Baltimore, MD, USA
Stretch-Dependent Ca2+ Signaling in Cardiac Ventricular Myocytes

9:25 –9:50 AM
Sandor Gyorke, Ohio State University, Columbus, OH, USA
Regulation of SR Ca2+ Release in Health and Cardiac Disease

9:50–10:15 AM
Shi-Qiang Wang, Life Sciences College, Peking University, Beijing, China
Spiral Ca2+ Waves “Sparked” by Fatal Mutation of Ryanodine Receptors in Single Heart Cells

10:15–10:30 AM
Natalia S. Torres*, University of Utah, Salt Lake City, UT, USA
Neuronal Na+ Currents are an Essential Component of the Trigger Mechanism in Heart

10:30–10:50 AM
Coffee/Tea Break

10:50 –11:15 AM
Rui-Ping Xiao, Shenzen Graduate School, Peking University, Beijing, China
Ca2+/CaMKII in the Heart

11:15–11:30 AM
Zheng Liu, Wadsworth Center, NY State Department of Health, Albany, NY, USA
Two Potential Calmodulin Binding Sequences in the Cardiac Ryanodine Receptor Form an Inter-subunit Binding Pocket for Calmodulin

11:30–11:55 AM
Long-Sheng Song, University of Iowa, Iowa City, IA, USA
T-tubule Remodeling and Ca2+ Dysfunction in Heart Disease

11:55 AM–12:45 PM
Lunch

12:45–2:15 PM Poster Session II

Session 8: Skeletal and Smooth Muscles
Session Co-Chairs
Withrow G. Wier, University of Maryland, Baltimore, Baltimore, MD, USA
Eduardo Rios, Rush University, Chicago, IL, USA

2:15–2:40 PM
Eduardo Rios, Rush University, Chicago, IL, USA
Control of Ca2+ Release in Skeletal Muscle. The Role of Ca2+ Content in the Cellular Store

2:40–3:05 PM
Jason X.-J. Yuan, University of Illinois, Chicago, Chicago, IL, USA
Role of TRP Channels in Pulmonary Arterial Hypertension

3:05–3:30 PM
Mark T. Nelson, University of Vermont, Burlington, VT, USA
Ca2+ Signaling in the Neurovascular Unit

3:30 –3:50 PM
Coffee/Tea Break

Session 8 (continued): Skeletal and Smooth Muscles
Session Chair
Mark T. Nelson, University of Vermont, Burlington, VT, USA

3:50– 4:15 PM
Withrow G. Wier, University of Maryland, Baltimore, Baltimore, MD, USA
Genetically-encoded Biosensor Methods for Observing Ca2+ Signaling in Arteries of the Living Mouse

4:15–4:40 PM
Jin Zhang, University of Maryland, Baltimore, Baltimore, MD, USA
Na+/Ca2+ Exchanger: A Key Player in the Regulation of Arterial Contraction and Blood Pressure

4:40–4:50 PM
Closing Remarks
The Organizing Committe
e

6:30 PM
Closing Banquet


*Early Investigator Awardee

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