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Sunday, June 5, 2022

5:00 PM - 6:00 PM
Registration

6:00 PM - 7:00 PM
Welcome Reception

7:00 PM - 8:00 PM
Dinner

8:00 PM - 8:15 PM
Opening Remarks
Merritt Maduke, Stanford University and Linda Columbus, University of Virginia, Conference Organizers

8:15 PM - 9:15 PM
Keynote Address
Anne Kenworthy, University of Virginia
How to Build, Manipulate, and Destroy Functional Nanodomains

9:15 PM - 9:45 PM
Flash Introduction

Monday, June 6, 2022

7:00 AM - 8:30 AM
Breakfast

Session I: Mechanotransduction in the Membrane
Miriam Goodman, Stanford University, Chair

9:00 AM - 9:30 AM
Miriam Goodman, Stanford University
Deciphering Where and How Touch Happens

9:30 AM - 10:00 AM
Bianxiao Cui, Stanford University
Membrane Curvature Initiated Mechanotransduction in Cells

10:00 AM - 10:30 AM
Kate Poole, University of New South Wales, Sydney, Australia
Multiple Pathways of Mechanoelectrical Transduction in Melanoma Cells

10:30 AM - 11:00 AM
Coffee Break and Group Photo

11:00 AM - 11:30 AM
Medha Pathak, University of California, Irvine
PIEZO1 on the Move

11:30 AM - 11:45 AM
Zheng Shi, Rutgers University *
Membrane Curvature Mediated Subcellular Distribution of PIEZO1

11:45 AM - 12:00 PM
Zhouyang Shen, Memorial Sloan Kettering *
A Synergy Between Mechanosensitive Calcium- and Membrane-Binding Mediates Tension-Sensing by C2-Like Domains

12:00 PM - 1:00 PM
Special-topic hosted Lunch Table
Teaching and Mentoring: inclusive practices (Linda Columbus)

1:00 PM - 2:30 PM
Panel Discussion: Challenges of Diversity and Inclusion in Science and Developing Action-Plans for Overcoming Them
Panelists: Linda Columbus, Karen Fleming, Miriam Goodman, Carlos Villalba-Galea

2:30 PM - 4:00 PM
Free Time

4:00 PM - 6:00 PM
Poster Session I

6:00 PM - 7:00 PM
Dinner

Session II: Membrane Organization
Sergio Grinstein, University of Toronto, Canada, Chair

7:00 PM - 7:30 PM
Sergio Grinstein, University of Toronto, Canada
Integration of Mechanosensory Signals by the Spectrin Cytoskeleton in Endothelial Cells

7:30 PM - 8:00 PM
Susan Daniel, Cornell University
Coronavirus Fusion Peptide Interactions with the Host Membrane Leads to Lipid Ordering and Membrane Fusion

8:00 PM - 8:30 PM
Syma Khalid, University of Oxford, United Kingdom
Progress Towards a Computational Bacteriology Approach to Studying Gram-Negative Bacterial Membranes

8:30 PM - 8:45 PM
Ting-Sung Hsieh, UT Southwestern *
Dynamic Remodeling of Host Membranes by Self-Organizing Bacterial Effectors

8:45 PM - 9:00 PM
Ivan Castello Serrano, University of Virginia *
Rafting in a Rush: Membrane Microdomains in Secretory Trafficking

9:00 PM - 11:00 PM
Mixer

Tuesday, June 7, 2022

7:00 AM - 8:30 AM
Breakfast

Session III: Signaling through the Membrane
William Kobertz, University of Massachusetts Medical School, Chair

9:00 AM - 9:30 AM
William Kobertz, University of Massachusetts Medical School
Fluorescent Visualization of Cellular Fluxes

9:30 AM - 10:00 AM
Anne Carlson, University of Pittsburgh
Phosphate Position is Key in Mediating the TMEM16A-PI(4,5)P2 Interaction

10:00 AM - 10:30 AM
Ming-Feng Tsai, University of Colorado
Mechanisms and Significance of Tissue-Specific Mitochondrial Calcium Uptake

10:30 AM - 10:45 AM
Coffee Break

10:45 AM - 11:15 AM
Patrick Barth, EPFL, Switzerland
Uncovering and Reprogramming Allosteric Signal Transductions in GPCRs

11:15 AM - 11:45 AM
Carlos Villalba-Galea, University of the Pacific
New Insights into the Modal Activity of KV7 Channels

11:45 AM - 12:00 PM
Jorge E. Contreras, University of California, Davis *
Large-Pore Channels as Transporters: Lessons from Connexin, Pannexin and CALHM1 Channels

12:00 PM - 1:00 PM
Special-topic hosted Lunch Table
Careers: Being a Professor at a Teaching University (Carlos Villalba-Galea)

1:00 PM - 2:30 PM
Workshop: Tips for Successful NIH Grant Proposals
Zhongzen Nie, NIH, NIGMS

2:30 PM - 4:00 PM
Free Time

4:00 PM - 6:00 PM
Poster Session II

6:00 PM - 7:00 PM
Dinner

Session IV: Membrane Shape
Dimitrios Stamou, University of Copenhagen, Denmark, Chair

7:00 PM - 7:30 PM
Dimitrios Stamou, University of Copenhagen, Denmark
Membrane Curvature as A Regulator of GPCR Organization at the Plasma Membrane

7:30 PM - 8:00 PM
Alexey Ladokhin, University of Kansas
Lipids and Divalent Cations as Regulators of Bilayer Insertion of pHLIP and Bcl-2 Proteins

8:00 PM - 8:30 PM
Jeet Kalia, Indian Institute of Science Education and Research Bhopal, India
Employing the Double Knot Toxin-TRPV1 Ion Channel Complex as a Model System to Interrogate the Roles of Protein-Membrane Interactions in Protein Function

8:30 PM - 8:45 PM
Tugba N. Ozturk, Washington University *
Elimination of Membrane Deformations Drives CLC-ec1 Dimerization

8:45 PM - 9:00 PM
Giacomo Fiorin , NIH *
Potentials of Mean Force of Biomembrane Deformation

9:00 PM - 11:00 PM
Mixer

Wednesday, June 8, 2022

7:00 AM - 8:30 AM
Breakfast

Session V: Ion Channels and Transporters
Joseph Mindell, NINDS, NIH, Chair

9:00 AM - 9:30 AM
Erkan Karakas, Vanderbilt University
Structural Basis for Activation and Gating of IP3 Receptor Calcium Channels

9:30 AM - 10:00 AM
Joseph Mindell, NINDS, NIH
Fat Chances: How a Signaling Lipid Influences Lysosomal pH Via the Chloride Transporter ClC-7

10:00 AM - 10:30 AM
Emily Liman, University of Southern California
Structure and Function of the OTOP Proton Channels

10:30 AM - 10:45 AM
Coffee Break

10:45 AM - 11:15 AM
Randy Stockbridge, University of Michigan
Structural Determinants of Substrate Specificity in Small Multidrug Resistance Transporters

11:15 AM - 11:30 AM
Olive E. Burata, University of Michigan *
Elucidating the Substrate Specificities of the Two Major Functional Subtypes in the Small Multidrug Resistance (SMR) Family

11:30 AM - 11:45 AM
Huong T. Kratochvil, University of California, San Francisco *
Designed Proton Channels Reveal Mechanisms for Proton Channel Selectivity and Conductivity

11:45 AM - 12:00 PM
Jun Chen, Genentech *
TRPA1 – Biased Agonism and Structural Mechanisms of Modulation

12:00 PM - 1:00 PM
Special-topic hosted Lunch Table
Careers: Research in Biotech (Jun Chen, Genentech)

1:00 PM - 2:30 PM
Panel Discussion: Establishing Expectations and Benchmarks in Collaborations Between Experiment and Computation
Panelists: Linda Columbus, Jessica Swanson, Syma Khalid, and Joseph Mindell

2:30 PM - 4:00 PM
Free Time

4:00 PM - 6:00 PM
Poster Session III

6:00 PM - 6:30 PM
Dinner

6:30 PM - 7:00 PM
Business Meeting

Session VI: Membrane Protein Dynamics
Linda Columbus, University of Virginia, Chair

7:00 PM - 7:30 PM
Linda Columbus, University of Virginia
Impact of Lipid-Membrane Protein Interactions on Membrane Protein Structure and Dynamics

7:30 PM - 8:00 PM
Jessica Swanson, The University of Utah
Kinetic selection of competing ion exchange pathways: When does the electrical versus chemical gradient matter?

8:00 PM - 8:30 PM
Lynmarie Thompson, University of Massachusetts, Amherst
NMR and Hydrogen Exchange Studies of Bacterial Chemotaxis Receptor Complexes Suggest Protein Stabilization is Key to the Signaling Mechanism

8:30 PM - 8:45 PM
Shwetha Srinivasan, Massachusetts Institute of Technology *
Lipid Dependence of the Conformational Coupling Across the Membrane Bilayer of Full-Length Epidermal Growth Factor Receptor

8:45 PM - 9:00 PM
Damien Thévenin, Lehigh University *
Promoting Receptor Protein Tyrosine Phosphatase Activity by Targeting Transmembrane Domain Interactions

9:00 PM - 11:00 PM
Mixer

Thursday, June 9, 2022

7:00 AM - 8:30 AM
Breakfast

Session VII: Membrane Protein Folding
Karen Fleming, Johns Hopkins University, Chair

9:00 AM - 9:30 AM
Karen Fleming, Johns Hopkins University
SurA: a “Groove-y” Chaperone That Expands Unfolded Outer Membrane Proteins

9:30 AM - 10:00 AM
Jonathan Schlebach, Indiana University Bloomington
Coordination of -1 Programmed Ribosomal Frameshifting by the Transcript and Nascent Polypeptide

10:00 AM - 10:30 AM
Ismael Mingarro, University of Valencia, Spain
Deciphering an Interfaciality Scale for Proteins at Biological Membranes

10:30 AM - 10:45 AM
Coffee Break

10:45 AM - 11:15 AM
Joanna Slusky, University of Kansas
Colicin E1 Opens Its Hinge to Plug TolC

11:15 AM - 11:30 AM
Kaitlyn V Ledwitch, Vanderbilt University *
Integrative Structural Modeling of Membrane Proteins Using Sparse Paramagnetic NMR and Neutron Scattering Data

11:30 AM - 11:45 AM
Zuzana Coculova, University of Oxford, United Kingdom *
Droplet-On-Hydrogel Bilayer Based Assay for Functional Study of Membrane Proteins

11:45 AM - 12:00 PM
Shirley Schreier, University of San Paola, Brazil *
Half a Century Deciphering Membrane Structure, Dynamics and Function Based on a Commentary in Biophysical Reviews, 13:849–852 (2021)

12:00 PM - 1:00 PM
Special-topic hosted Lunch Table
Publishing: Thoughts from the Perspective of Academic Editors (Dimitrios Stamous, BJ editor; Joseph Mindell, JGP editor, Merritt Maduke, eLife & BJ editor)

1:00 PM - 4:00 PM
Free Time

4:00 PM - 6:00 PM
Poster Session IV

6:00 PM - 7:00 PM
Dinner
Closing Remarks and Biophysical Journal Poster Awards

Session VIII: Membrane Remodeling, Fusion, and Exocytosis
Kelly Lee, University of Washington

7:00 PM - 7:30 PM
Kelly Lee, University of Washington
Dissecting Membrane Structure and Remodeling Using Cryo-Electron Tomography

7:30 PM - 8:00 PM
Gregory Voth, University of Chicago
Membrane Remodeling by Proteins: Insights and Surprises from Multiscale Computer Simulation

8:00 PM - 8:30 PM
Peter Kasson, University of Virginia
Protein Activation and Membrane Deformation in Enveloped Virus Entry

8:30 PM - 8:45 PM
Volker Kiessling, University of Virginia *
Lipid Protein Interactions Guiding Fusion Pore Opening and Expansion During Regulated Exocytosis

8:45 PM - 9:00 PM
Joana Paulino, University of California San Francisco *
Characterization of the Elusive SERINC5-AP2-Nef Complex in the Context of a Lipid Bilayer

9:00 PM - 11:00 PM
Mixer

Friday, June 10, 2022

7:00 AM - 8:30 AM
Breakfast and Departure
 

* Short Talks selected from among submitted abstracts