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Monday, September 3, 2018

17:30 - 20:00
Registration

18:00 - 20:00
Welcome Reception

Tuesday, September 4, 2018

8:00 - 18:00
Registration

8:45 - 9:00
Opening Remarks

Session I: Disease & Modelling I

9:00 - 9:35
Stefan Luther, Max Planck Institute for Dynamics and Self-Organization, Germany

Low-energy Control of Cardiac Arrhythmias

9:35 - 10:10
Colleen Clancy, University of California, Davis, USA
Sex, Drugs and Funky Rhythms: Cardiology Insights form Modeling and Simulation

10:10 - 10:30
Hermenegild Arevalo, Simula Research Laboratory, Norway *
Using Virtual Hearts Models to Investigate Arrhythmogenesis during Acute Myocardial Infarction

10:30 - 10:50
Marcus Kelm, German Heart Institute Berlin, Germany *
EurValve

10:50 - 11:10
Coffee Break

Session II: Disease & Modelling II

11:10 - 11:45
Isabelle van Gelder, University of Groningen, Netherlands
How to Improve Diagnostics and Therapies in Atrial Fibrillation - Why We Need the Basic Sciences!

11:45 - 12:20
Edward Vigmond, University of Bordeaux, France
Biophysical Models of the Fibrillating Atria: Fibrosis and Electrophysiological Considerations

12:20 - 12:55
Yohannes Shiferaw, California State University, Northridge, USA
Synchronization of Stochastic Calcium Waves in Atrial Tissue

12:55 - 13:25
Lunch Break

13:25 - 14:45
Poster Session I

Session III: Disease & Modelling III

14:45 - 15:20
Natalia Trayanova, Johns Hopkins University, USA
Computational Cardiology: Blending Engineering and Medicine

15:20 - 15:55
Steven Niederer, King's College London, United Kingdom
Clinical Translation of Cardiac Models

15:55 - 16:30
Emilia Entcheva, George Washington University, USA
Massively-parallel All-optical Cardiac Electrophysiology

16:30 - 16:50
Coffee Break

Session IV: Disease & Modelling IV

16:50 - 17:25
Martyn Nash, University of Auckland, New Zealand
Structure-function Mechanisms of Heart Failure

17:25 - 18:00
Andrew McCulloch, University of California, San Diego, USA
Multi-scale Biomechanics and Systems Mechanobiology of Heart Failure

Wednesday, September 5, 2018

8:30 - 17:50
Registration

Session V: Excitation Contraction Coupling I

9:00 - 9:35
Julia Gorelik, Imperial College London, United Kingdom
Microdomain Specific Regulation of L-type Ca Channels and Arrhythmias

9:35 - 10:10
Alexandra Zahradnikova, Slovak Academy of Sciences, Slovakia
Allosteric Aspects of Ryanodine Receptor Gating

10:10 - 10:30
David J. Christini, Cornell University, USA *
Designing Intact Cardiac Cell Electrophysiological Protocols to Improve Computational Model Fidelity

10:30 - 10:50
Jamie I. Vandenberg, Victor Chang Cardiac Research Institute, Australia *
Impact of Correlated Gene Expression Patterns on Population Models of the Cardiac Action Potential

10:50 - 11:10
Coffee Break

Session VI: Metabolism & Mitochondria

11:10 - 11:45
Daniel Beard, University of Michigan, USA
Elucidating Links Between Disruptions to Myocardial Energy Metabolism and Mechanical Dysfunction in Heart Failure

11:45 - 12:20
Brian O’Rourke, Johns Hopkins University, USA
Cascading Mitochondrial Network Failure: Computational and Experimental Studies

12:20 - 12:40
Zhen Song, University of California, Los Angeles, USA *
A Spatially Detailed in Silico Model of Excitation-Contraction-Metabolism Coupling of Cardiac Cells 

12:40 - 13:10
Lunch Break

13:10 - 14:30
Poster Session II

Session VII: Excitation Contraction Coupling II

14:30 - 15:05
Daniela Panakova, Max Delbrück Center for Molecular Medicine, Germany
Wnt, L-Type Calcium Channel, and the Developing Heart 

15:05 - 15:40
Christian Soeller, University of Exeter, United Kingdom
Characterisation of Ryanodine Receptor Clusters in Cardiac Myocytes Using Quantitative Imaging Methods

15:40 - 16:00
Richard Clayton, University of Sheffield, United Kingdom *
Calibration of Human Atrial Cell Models Using Bayesian History Matching with Gaussian Process Emulators

Session VIII: Data Driven Modelling

16:00 - 16:55
Elizabeth Cherry, Rochester Institute of Technology, USA
Reconstructing Cardiac Electrical Dynamics Using Data Assimilation

16:55 - 17:30
Leonid Goubergrits, Charité – Universitätsmedizin Berlin, Germany
Modelling and Simulation for the Aortic Valve Treatment Planning Using Image-based CFD

17:30 - 17:50
Juan Carlos del Alamo, University of California, San Diego, USA  *
Patient-specific Mapping of Blood Stasis in the Left Atrium by Computational Fluid Dynamics

Thursday, September 6, 2018

8:30 - 14:50
Registration

Session IX: Arrythomgenesis and Its Control I

9:00 - 9:35
Martin Bishop, King's College London, United Kingdom
Identifying the Arrhythmogenic Mechanisms Driven by Midwall Fibrosis in Non-Ischemic Dilated Cardiomyopathy

9:35 - 10:10
Jonathan Lederer, University of Maryland, USA
Diastolic Calcium in Heart: CA2+ Quarjs, CA2+ Sparks, CA2+ Waves and Arrhythmias

10:10 - 10:30
Johann Schredelseker, Ludwig-Maximilians-University of Munich, Germany *
Activation of Mitochondrial Calcium Uptake Suppresses Arrhythmogenesis in Cardiomyocytes

10:30 - 10:50
Michael B. Liu, University of California, Los Angeles, USA *
Arrhythmogenesis in Long QT Syndrome: Mechanism of Initiation and Therapeutic Insight from an in Silico Human Model

10:50 - 11:10
Coffee Break

Session X: Arrythomgenesis and Its Control II

11:10 - 11:45
Donald Bers, University of California, Davis, USA
Cardiac Excitation-contraction Coupling, Arrhythmias and Signaling: Experiments and Modelling

11:45 - 12:20
Alexander Panfilov, Gent University, Belgium
In Silico–in vitro Approach to Study the Mechanisms of Cardiac Arrhythmias

12:20 - 12:40
Vivian Timmermann, Simula Research Laboratory, Norway *
A Computational Study of the Contribution of Mechano-electric Feedback to Arrhythmogenic Current Generation

12:40 - 13:00
Fernando O. Campos, King's College London, United Kingdom *
Optimization of an Activation-repolarization Time Metric to Detect Localized Susceptibility to Reentry

13:00 - 13:30
Lunch Break

13:30 - 14:50
Poster Session III

14:50 - 18:00
Free Time

18:00 - 21:00
Boat Trip/Banquet

Friday, September 7, 2018

8:30 - 15:30
Registration

Session XI: Excitation Contraction Coupling III

9:00 - 9:35
Pieter de Tombe, Loyola University Chicago, USA
Frank-starling Law of the Heart: Molecular Mechanisms of Myofilament Length Dependent Activation

9:35 - 10:10
Michael Gotthardt, Max Delbrück Center for Molecular Medicine, Germany
Theory and Practice of Titin Based Mechanotransduction

10:10 - 10:30
Kenneth Campbell, University of Kentucky, USA *
Force-dependent Recruitment of Cross-bridges from the Myosin Off-state Can Contribute to Length-dependent Activation in Cardiac Muscle

10:30 - 10:50
Lorenzo Marcucci, University of Padova, Italy *
Proposed Mechanism of Length Dependent Maximum Force Developed in Striated Muscle at High Calcium

10:50 - 11:10
Coffee Break

Session XII: Excitation Contraction Coupling IV

11:10 - 11:45
Mary Maleckar, Allen Institute for Cell Science, USA
Modeling Experimental Insights from hIPSC and Derived Cells: Integrating the Cardiomyocyte

11:45 - 12:20
Frank Heinzel
Regulation of Subcellular Ca2+ as Source of Intracellular Dyssynchrony in Cardiomyocytes 

12:20 - 12:40
Samuel Wall, Simula Research Laboratory, Norway *
In Silico Modeling of Cardiac Microphysiological Systems for Evaluating Drug Side Effects

12:40 - 13:20
Lunch Break

Session XIII: Excitation Contraction Coupling V

13:20 - 13:55
Peter Kohl, Institute for Experimental Cardiovascular Medicine, Germany
Sat-Nav for the Inner Citties of the Heart: Mapping 3D Cell-Nanostructure

13:55 - 14:15
Enrique Alvarez-Lacalle, Polytechnic University of Catalonia, Spain *
A General Equilibrium Model to Study Intracellular Calcium Homeostasis. New Insights on Ventricular Function

14:15 - 14:35
Coffee Break

Session XIV: Re-entry

14:35 - 14:55
Vladimir Zykov, Max Planck Institute for Dynamics and Self-Organization, Germany *
Fast Propagation Regions of a Specific Geometry can Cause Reentry in Excitable Media

14:55 - 15:15
Michael Colman, University of Leeds, United Kingdom *
Dynamic Organ-scale Modelling of Sub-cellular Calcium Release Events in the Heart: After-depolarisations, Premature Excitation and Re-entry

15:15 - 15:30
Closing Remarks and Biophysical Journal Poster Awards

*Short talks selected from among submitted abstracts