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2006
Biophysical Society Discussions Study Book
Molecular Motors: Point Counterpoint
October 19-22, 2006
Organizers: Sharyn Endow, Duke University and
Steven Rosenfeld, Columbia University
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Thursday Evening - Oct 19, 2006
7:30 pm
Opening Talk -
Foreword
Sharyn A. Endow and Steven S. Rosenfeld,
Co-organizers
7:40 pm
Overview: Major Unresolved
Questions for all Motor Families.
Yale Goldman, University of
Pennsylvania.
Session concludes at 8:30 pm
Friday Morning - Oct 20, 2006
9:00 am
Session I. Motor walking (and
Limping) Mechanisms, including Mechanisms of Processivity.
Robert Cross, Marie
Curie Research Institute, UK, Chair
9:10 am
Myosins.
James Spudich, Stanford University.
9:45 am
Kinesin Motor Mechanics:
Binding, Stepping, Tracking, Gating, Limping, ...and Some Newly Discovered
Rotational States.
Steven Block, Stanford University.
10:20 am
Dyneins.
Hideo Higuchi, Tohoku University, Japan.
10:55 am
Coffee Break
11:10 am
Ribosomes & Other Macromolecular
Complexes.
Koen Visscher, University of Arizona.
11:45 am
Poster Session I Review
Sarah Rice, Northwestern
University
Session Concludes at 11:55 am
Friday Evening - Oct 20, 2006
7:00 pm
Session II. Force Generating
Mechanisms and Mechanochemical Transduction.
Claudia Veigel, National Institute for Medical Research, MRC, UK,
Chair
7:10 pm
The Strain
of Myosins Working One-Two-Five. - Revised October 12
Justin Molloy, National Institute for Medical Research, MRC, UK
7:45 pm
Kinesins
F. Jon Kull, Dartmouth College
8:20 pm
Coffee Break
8:35 pm
Ion Channels
Paul Selvin, University of Illinois
9:10 pm
Rotary Motors
Hiroyuki Noji, University of
Tokyo
Session Concludes at 9:45 pm
Saturday Morning - Oct 21, 2006
9:00 am
Session III. Determinants of
Motor Directionality
H. Lee Sweeney, University of Pennsylvania,
Chair
9:10 am
Myosins
Anne Houdusse, Institute Curie, France
9:45 am
Kinesins
Ron Milligan, Scripps Research Foundation
10:20 am
Helicase Directional
Movement
Taekjip Ha, University of Illinois
10:55 am
Coffee Break
11:10 am
Bacteria & Polymerization
Motors
Daniel Fletcher, University of California, Berkeley
11:45 am
Poster Session II Review
Meredith Betterton,
University of Colorado, Boulder, and Margot Quinlan, University of
California, San Francisco
Session Concludes at 11:55 am
Saturday Evening - Oct 21, 2006
7:00 pm
Session IV. Mechanisms of Motor
Regulation
Richard Vallee, Columbia University,
Chair
7:10 pm
Motor Regulation: Cellular
Mechanisms
Meg Titus, University of
Minnesota
7:45 pm
Motor-Cargo Regulation
Nobutaka Hirokawa, University of Tokyo, Japan
8:20 pm
Coffee Break
8:35 pm
Motor-driven Transport
Regulation by Interacting Proteins
Steven Gross, University of California,
Irvine
9:10 pm
Filament Dynamics &
Motor-Filament Interactions
David Odde, University
of Minnesota
Session Concludes at 9:45 pm
Sunday Morning - Oct 22, 2006
8:30 am
Session V. Motors in the Cell
Ron Vale, University
of California, San Francisco, Chair
8:40 am
Force Generation by Myosins
during Morphogenesis
Dan Kiehart, Duke University
9:15 am
Mitotic Spindle Assembly
Tarun Kapoor, Rockefeller
University
9:15 am
Summary: What We Have Learnt
and Where are We Going?
Jonathan Howard, Max Planck
Institute, Dresden, Germany
10:30 am
Closing Remarks
Steven Rosenfeld, Columbia
University
Session Concludes at 11:00 am
Invited Discussants:
Kenneth Holmes, Max Planck
Institute, Heidelberg, Germany.
Toshio Yanagida, Osaka University, Japan.
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