Daily Schedule

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October 11
October 12
October 13
October 14
October 15

Saturday, October 11

4:00 PM - 5:30 PM Registration (Davenport Hotel Lobby)
6:00 PM - 7:30 PM Opening Reception

Sunday, October 12

8:00 AM Registration/Information 

SESSION I: Regulation of Motif Interactions Through Post-Translational Modification (Co-Chairs: Richard Kriwacki & M. Madan Babu)
9:00 - 9:10 AM Welcome/Opening Remarks
9:10 - 9:40 AM Peter Wright, The Scripps Research Institute, USA
Intrinsic Disorder, Posttranslational Modification, and Signaling Complexity
9:40 - 9:55 AM Diana Mitrea, St. Jude Children's Research Hospital, USA*
Acidic Patches in Nucelophosmin Recruit Nucleolar Proteins via Arginine-Rich Linear Motifs
9:55 - 10:25 AM Stephan Feller, Institute of Molecular Medicine, Germany
Signal Computation in Large Multi-protein Complexes Assembled on Mostly Disordered Platform Proteins
10:25 - 10:55 AM Coffee Break
10:55 - 11:25 AM Richard Kriwacki, St. Jude Children's Research Hospital, USA
Structural Biology of Disordered Motifs in Regulation of Apoptosis and Cell Division
11:25 - 11:40 AM Birthe Kragelund, University of Copenhagen, Denmark*
Intrinsic Disorder in Membrane Proteins
11:40 AM - 12:10 PM Mart Loog, University of Tartu, Estonia
Multisite Phosphorylation Networks in Cdk1-dependent Cell Cycle Regulation
12:10 - 2:00 PM Lunch
 SESSION II: Methods in Molecular and System Level Studies of Motif Biology (Co-Chairs: Susan Taylor & Rohit Pappu)
2:00 - 2:30 PM Jin Wang, State University of New York, Stony Brook, USA, Changchun Institute of Applied Chemistry, China
Specificity and Affinity Quantification of Flexible Recognition from Underlying Energy Landscape Topography
2:30 - 3:00 PM  Jörg Gsponer, University of British Columbia, Canada
Fast Computational Identification of MoRFs in Protein Sequences
3:00 - 3:15 PM Perdita Barran, The University of Manchester, United Kingdom*
The Use of Mass Spectrometry to Determine the Disordered Content of Proteins
3:15 - 3:45 PM Zhirong Liu, Peking University, China
Interaction Specificity of Intrinsically Disordered Proteins
3:45 - 4:15 PM Coffee Break
4:15 - 4:45 PM Martin Blackledge, Institut de Biologie Structurale, France
Relating Conformational Flexibility to Cellular Function in Intrinsically Disordered Viral and Signalling Proteins
4:45 -  5:00 PM Iris Antes, Technical University of Munich, Germany*
Computational Prediction of Protein-Peptide Binding
5:00 - 5:30 PM Norman Davey, University of California, San Francisco, USA
The Discovery and Characterization of a Novel Class of APC/C Activator Binding Motif Required for Ordered Cyclin Destruction and Spindle Assembly Checkpoint Integrity
5:30 - 6:00 PM Keith Dunker, Indiana University, USA
Close Encounters of the Third Kind: Disordered Binding Domains
6:00 - 8:00 PM Dinner on own
8:00 - 10:00 PM Poster Session 1
* Short talks to be selected from among submitted abstracts

Monday, October 13 

8:00 AM Registration/Information

SESSION III:System-wide Identification of Functional Motifs; How Much Biology are We Missing? (Co-Chairs: Jörg Gsponer & Toby Gibson)
9:00 - 9:30 AM M. Madan Babu, Laboratory of Molecular Biology, United Kingdom
Increasing Functional Versatility of Disordered Proteins through Alternative Splicing and Asymmetric mRNA Localisation (updated)
9:30 - 9:45 AM Ylva Ivarsson, Uppsala University, Sweden*
Interaction Profiling using Phage Peptidomes
9:45 - 10:15 AM Alan Moses, University of Toronto, Canada
Tinkering with Signaling: Evolution of Short Linear Motifs in Disordered Regions
10:15 - 10:45 AM Coffee Break
10:45 - 11:15 AM Anna Akhmanova, Utrecht University, The Netherlands
Control of Protein Localization to Microtubule Tips by Disordered Motifs
11:15 - 11:45 AM Denis Shields, University College Dublin, Ireland
Enigmas of Protein Disorder and Motif Evolution in Viruses and Across Diverse Species
11:45 AM - 12:00 PM Pia Harryson, Stockholm University, Sweden*
Plant Stress: Membrane Binding of the Disordered Plant Dehydrins
12:00 - 12:30 PM Philip Kim, University of Toronto, Canada
Novel Drug Leads: Highly Parallel Screening of Disordered Peptide Motifs for Phenotypic Effects in Cells
12:30 - 2:00 PM Lunch
 SESSION IV: Molecular Hand-offs During a Protein's Lifetime: From Ribosome to Proteasome (Co-Chairs: Anna Akhmanova & Sonia Longhi)
2:00 - 2:30 PM Brenda Schulman, St. Jude Children's Research Hospital, USA
Dynamic Mechanisms Underlying Ubiquitin Ligation
2:30 - 3:00 PM Edward Lemke, European Molecular Biology Laboratory, Germany
Decoding Protein Plasticity from Single Molecules to Large Complexes
3:00 - 3:15 PM Marie-France Carlier, CNRS, France*
Control of Actin Filament Assembly by Multifunctional WASP- Homology 2 (WH2) Domains
3:15 - 3:45 PM Shu-ou Shan, California Institute of Technology, USA
Decision Making and Molecular Interplay during Protein Biogenesis
3:45 - 4:15 PM Coffee Break
4:15 - 4:45 PM Elisar Barbar, Oregon State University, USA
Protein Disorder and Polybivalency in Allosteric Regulation of Large Molecular Machines
4:45 - 5:00 PM Kuan Wang, Academia Sinica, Taiwan*
Intrinsically Disordered Titin PEVK Motifs: The Interplay of Force, Form and Function of an Ion-exchange Driven Elastomer
5:00 - 5:30 PMKylie Walters, National Cancer Institute, USA
Riding with the Ubiquitin Ticket
5:30 - 5:45 PM Gary Daughdrill, University of South Florida, USA*
Disorder and Residual Helicity Alter p53-Mdm2 Binding Affinity and Signaling in Cells
5:45 - 6:15 PM Harvey McMahon, MRC Laboratory of Molecular Biology, United Kingdom
Maturation of Clathrin-coated Vesicles Requires Dynamic Instability and Processivity
6:15 - 8:00 PM Dinner on own
8:00 - 10:00 PM Poster Session II
* Short talks to be selected from among submitted abstracts

Tuesday, October 14 

8:00 AM Registration/Information

SESSION V: Dynamics within Protein Complexes and Roles in Regulation (Co-Chairs: Brenda Schulman & Keith Dunker)
9:00 - 9:30 AM Toby Gibson, European Molecular Biology Laboratory, Germany
Regulation by In-complex Molecular Switching
9:30 - 9:45 AM Abel Garcia-Pino, Vrije Universiteit Brussel, Belgium*
Entropic Exclusion Determines Allostery in a Major Family of Intrinsically Disordered Bacterial Transcription Factors
9:45 - 10:15 AM Jane Dyson, The Scripps Research Institute, USA
Role of Functional Disorder in Large Protein Complexes
10:15 - 10:45 AM Coffee Break
10:45 - 11:15 AM Liesbeth Veenhoff, University of Groningen, The Netherlands
Disordered Linker Regions for Sorting of Transmembrane Proteins
11:15 - 11:30 AM Vincent Hilser, Johns Hopkins University, USA*
Parallel Tuning of Activation and Repression in Intrinsic Disorder-Mediated Allostery
11:30 AM - 12:00 PM Susan Taylor, University of California, San Diego, USA
PKA Signaling: Linkers, Loops, and Intrinsically Disorder Regions Control Allostery
12:00 - 3:00 PM Lunch and Dublin Sightseeing

SESSION VI: Motifs, Multi-valency and Membrane-less Organelles in Cells (Co-Chairs: Peter Tompa & Peter Wright)
3:00 - 3:30 PM Dirk Görlich, Max Planck Institute for Biophysical Chemistry, Germany
Nup98 FG-domains from Diverse Species Spontaneously Phase-separate into Hydrogels with Exquisite NPC-like Permeability
3:30 - 3:45 PM Stephanie Weber, Princeton University, USA*
Inverse Size Scaling of the Nucleolus by a Concentration-Dependent Phase Transition
3:45 - 4:15 PM Tanja Mittag, St. Jude Children's Research Hospital, USA
The Role of Multivalent Interactions of Tumor Suppressor SPOP with Gli3 in Regulating Ubiquitination
4:15 PM - 4:45 PM Coffee Break
4:45 - 5:00 PM Chi Pak, University of Texas Southwestern, USA*
Discerning Sequence-encoded Mechanisms of de novo Nuclear Puncta Formation by the Disordered Nephrin Intracellular Domain
5:00 - 5:15 PM Patrick Farber, Hospital for Sick Children, Canada*
Phase Separation of a Disordered Protein in the Formation of Membrane-less Organelles
5:15 - 5:45 PM Roy Parker, University of Colorado, Boulder, USA
Assembly and Functions of mRNP granules in Eukaryotic Cells 
6:00 PM Dinner on own
* Short talks to be selected from amongst submitted abstracts

Wednesday, October 15 

8:00 AM Registration/Information

SESSION VII: Motifs that Drive Disease: A Biological Double-edged Sword (Co-Chairs: Tanja Mittag & Ashok Deniz)
9:00 - 9:30 AM Gilles Trave, University of Strasbourg, France
The Oncoproteins of Human Papillomaviruses: Instances of Viral Strategies for Hijacking of Host Motifs
9:30 - 9:45 AM Brian Bothner, Montana State University, USA*
The C-terminal Domain of Hepatitis B Virus Capsid Protein has Mastered being a Jack-of-all-trades
9:45 - 10:15 AM  Ashok Deniz, The Scripps Research Institute, USA
Single-molecule Biophysics of Protein Disorder and Misfolding
10:15 - 10:45 AM Coffee Break
10:45 - 11:15 AM Rohit Pappu, Washington University of St. Louis, USA
Modulation of Huntingtin Exon 1 Interactions through Synergy between Polyglutamine Tracts and Flanking Sequence Motifs
11:15 - 11:45 AM Sonia Longhi, CNRS et Université d' Axi-Marseille, France
How Order and Disorder within Paramyxoviral Nucleoproteins and Phosphoproteins Orchestrate the Molecular Ballet of Transcription and Replication

SESSION VIII: Motif Biology: State of Understanding and Future Directions (Chair: Norman Davey)
11:45 PM - 12:15 PM Peter Tompa, Vlaams Institute for Biotechnology, Belgium
Towards Describing IDP Function by Dynamic Structural Ensembles
12:15 - 12:45 PM  Closing Remarks/Farewell 

* Short talks selected from among submitted abstracts

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