Daily Schedule

Sunday, May 19

6:00 PM   
Reception
 
6:50 PM   
Welcome/Introduction

Evening Session: Membrane Protein Folding in the Cell

Chair: James Bowie, University of California, Los Angeles, USA

7:00 PM - 7:25 PM
William Skach, Oregon Health and Science University, USA
The Yin and Yang of Ribosome Function Shapes the Co-translational Folding Funnel during CFTR Biogenesis

7:25 PM - 7:50 PM
Joy Kim, Seoul National University, South Korea
Studies on Targeting and Insertion of Membrane Proteins in Yeast
 
7:50 PM - 8:05 PM
Ismael Mingarro, University of Valencia, Spain
Folding of Transmembrane Helices Inside the Ribosome Exit Tunnel
 
8:05 PM - 8:20 PM
Sebastian Hiller, Biozentrum, Switzerland
Mechanism of Membrane Protein Transport by a Periplasmic Chaperone
 
8:20 PM - 8:45 PM
Andreas Kuhn, University of Stuttgart, Germany
Reconstituted Membrane Insertion of Single Proteins in Real Time
 
8:45 PM - 9:10 PM
Koreaki Ito, Kyoto Sangyo University, Japan
Regulation of Membrane Translocation and Integration Systems by Ribosome Stalling
 

Monday, May 20

Morning Session: Forces that Drive Membrane Protein Folding

Chair: Karen Fleming, Johns Hopkins University, USA

8:00 AM - 9:00 AM
Breakfast
 
9:00 AM - 9:25 AM
Stephen White, University of California, Irvine, USA
Membrane Protein Assembly: Biology and Thermodynamics
 
9:25 AM - 9:50 AM
Peter Tieleman, University of Calgary, Canada
Modeling Helix-helix Interactions in Membrane Proteins
 
9:50 AM - 10:15 AM
Mark Sansom, University of Oxford, United Kingdom
Molecular Simulations of Membrane Proteins and their Lipid Interactions
 
10:15 AM - 10:30 AM
Judith Klein-Seetharaman, University of Warwick, United Kingdom
Differential Dynamics of Extracellular and Cytoplasmic Domains in Denatured States of Rhodopsin
 
10:30 AM - 10:50 AM
Break
 
10:50 AM - 11:15 AM
Heedeok Hong, Michigan State University
Steric Trapping: a Method to Measure Strong Protein-Protein Interactions in Lipid Bilayers   
 
11:15 AM - 11:40 AM
Bryan Krantz, University of California, Berkeley, USA
Molecular Insights on Anthrax Toxin Unfolding and Translocation across Membranes
 
11:40 AM - 12:00 PM
Break
 
12:00 PM - 12:25 PM
Emad Tajkhorshid, University of Illinois, USA
Accelerated Simulation of Membranes and Membrane-Associated Phenomena with a Novel Atomistic Membrane Mimetic Model
 
12:25 PM - 12:40 PM
Alexey Ladokhin, The University of Kansas Medical Center, USA
Thermodynamic Measurements of Membrane Protein Insertion Chaperoned by Fluorinated Surfactants
 
12:40 PM - 12:55 PM
Lindsay McMorran, University of Leeds, United Kingdom
Holdases and Foldases: How Unfolded Outer Membrane Proteins Cross the Periplasm
 
1:00 PM   
Lunch
 
2:00 PM - 4:00 PM
Free Time
 
4:00 PM - 6:00 PM
Reception/Poster Session I
 
6:00 PM    
Dinner 
 
Evening Session: How Membranes and Membrane Proteins Shape Each Other

Chair: Chiwook Park, Purdue University, USA

7:00 PM - 7:25 PM
Myunggi Yi, Pukyong National University, South Korea
Characterization of Ion Translocation in the Connexin Hemi- and Gap Junction Channels
 
7:25 PM - 7:50 PM
Tae-Young Yoon, Korea Advanced Institute of Science and Technology, South Korea
Mechanical Unzipping and Rezipping of a Single SNARE Complex Reveals Hysteresis as a Force-generating Mechanism
 
7:50 PM - 8:05 PM
Christina Scharnagl, Technical University Munich, Germany
The Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix Provides a Rationale for the Sequential Cleavage Mechanism of γ-Secretase
 
8:05 PM - 8:20 PM
Break
 
8:20 PM - 8:45 PM
Jakob Ulmschneider, Shanghai University, China
Partitioning Free Energies and Translocation Mechanism of Membrane Active Peptides via Long-Scale MD Simulations
 
8:45 PM - 9:10 PM
Yuji Sugita, RIKEN, Japan
Lipid Surface Area in Protein-Membrane Simulation Systems
 

Tuesday, May 21

8:00 AM - 9:00 AM
Breakfast

Early Morning Session: Membrane Protein Folding and Assembly

Chair: Sanguk Kim, POSTECH, South Korea

9:00 AM - 9:25 AM
Yangmee Kim, Konkuk University, South Korea
Structure-Activity Relationships of Membrane Active Antimicrobial Peptides from Insect and Their Mechanism of Action
 
9:25 AM - 9:50 AM
Chiwook Park, Purdue University, USA
Comprehensive Analysis of the Folding and Unfolding Kinetics of Bacteriorhodopsin
 
9:50 AM - 10:15 AM
Gerard Huysmans, Pasteur Institute, France
Sequential Assembly of the Multimeric Outer Membrane Secretin PulD
 
10:15 AM - 10:40 AM
Yinan Wei, University of Kentucky, USA
Dependence of Membrane Protein Activity on Oligomer Association Affinity
 
10:40 AM - 11:00 AM
Break

Late Morning Session: Membrane Protein Misfolding and Disease 

Chair:  Sanguk Kim, POSTECH, South Korea
 
11:00 AM - 11:25 AM
Jennifer Lee, National Heart Lung and Blood Institute, USA
Biophysics of α-Synuclein Membrane Interactions and Its Relevance to Disease
 
11:25 AM - 11:50 AM
Katsumi Matsuzaki, Kyoto University, Japan
Ganglioside Cluster-mediated Folding and Aggregation of Amyloid Beta-Proteins
 
11:50 PM - 12:15 PM
Charles Sanders, Vanderbilt University, USA
Molecular Insight into Alzheimer's and Charcot-Marie-Tooth Disease from Biophysical Studies of the Human Amyloid Precursor Protein and Peripheral Myelin Protein 22
 
12:15 PM
Group Photo 
 
12:30 PM
Lunch
 
1:00 PM - 6:00 PM
Excursion
 
6:00 PM    
Dinner
 
7:00 PM - 8:30 PM
Reception/Poster Session II

Evening Session: GPCR Structure/Function

Chair: Linda Columbus, University of Virginia, USA

8:30 PM - 8:55 PM
Weontae Lee, Yonsei University, South Korea
Structure and Function of GPCR: Application to Melanocortin Receptor Subtype Anti-Obesity Drug
 
8:55 PM - 9:20 PM
Ron Dror, D. E. Shaw Research, USA
Revealing Structural Dynamics of GPCR Signaling through Atomic-Level Simulation
 
9:20 PM - 9:35 PM
Yana Gofman, Stanford University, USA
Determination of Membrane Proteins Structure from Cryo-EM Density Maps Using Evolutionary Conservation Information
 

Wednesday, May 22

8:00 AM - 9:00 AM
Breakfast

Morning Session: Membrane Protein Structure Prediction and Design

Chair: Jooyoung Lee, KIAS, South Korea

9:00 AM - 9:25 AM
Wonpil Im, University of Kansas, USA
Quantitative Characterization of Transmembrane Helix-Helix and Helix-Lipid Bilayer Interactions
 
9:25 AM - 9:50 AM
Patrick Barth, Baylor College of Medicine, USA
High-Resolution Modeling and Design of Membrane Receptors
 
9:50 AM - 10:15 AM
Sanguk Kim, Pohang University of Science and Technology, South Korea
Fold Space and Function Annotation of Membrane Proteins
 
10:15 AM - 10:30 AM
Stephanie DeLuca, Vanderbilt University, USA
RosettaEPR: Combining Computational Rigid Body Sampling with Sparse EPR Data to Improve Membrane Protein Structure Determination
 
10:30 AM - 10:50 AM
Break
 
10:50 AM - 11:15 AM
Shoji Takada, Kyoto University, Japan
Co-Translational Folding Studied by Coarse-Grained Molecular Simulations
 
11:15 AM - 11:30 AM
Nathan Joh, University of California, San Francisco, USA
Testing the Alternate-Access Mechanism by De-Novo Designing a Transporter
 
11:30 AM - 11:55 AM
Jie Liang, University of Illinois at Chicago, USA
Computing Structure, Energetics, Protein-Protein Interactions, and Inferring Evolutionary Patterns of Bacterial Outer-Membrane and Eukaryotic Mitochondrial Proteins
 
11:55 AM - 12:20 PM
Don Engelman, Yale University, USA
pH-dependent Transmembrane Peptide Insertion: Mechanism and Uses in Tumor Targeting and Drug Delivery
 
12:30 PM  
Lunch  

Afternoon Session: Producing, Stabilizing, and Refolding Membrane Proteins

Chair: Heedeok Hong, Michigan State University, USA

2:30 PM - 2:55 PM
Linda Columbus, University of Virginia, USA
Physical Properties of Detergents to be Considered for Stabilizing Membrane Protein Structures
 
2:55 PM - 3:20 PM
Pil Seok Chae, Hanyang University, South Korea
Neopentyl Glycol (NG) Class Amphiphiles for Membrane Protein Structural Study
 
3:20 PM - 3:55 PM
Andreas Plückthun, University of Zurich, Switzerland
Evolving GPCRs for Maximal Detergent Stability and Structure Determination
 
3:55 PM - 4:20 PM
Takeshi Sato, Osaka University, Japan
Membrane Protein Structural Biology Focusing the Transmembrane-Juxtamembrane Region
 
4:20 PM - 4:45 PM
Jean-Luc Popot, Institute of Physical-Chemical Biology, France
Do Membrane Proteins Need to Fold in a "Membrane-Mimetic" Environment in Order to Reach a Functional 3D Structure?
 
5:30 PM 
Bus to Banquet
 
6:00 PM   
Banquet

 

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